Medical Disease and Alcohol Use Among Veterans With Human Immunodeficiency Infection
A Comparison of Disease Measurement Strategies
Bibliographic Data
| ID | 9099571 |
|---|---|
| Authors | Amy C Justice (0000-0003-0139-5502, Yale New Haven Hospital, corresponding author), Elaine Lasky (National Institute on Alcohol Abuse and Alcoholism), Kathleen A McGinnis (0000-0003-4844-3372, University of Pittsburgh), Melissa Skanderson (0000-0002-5539-8680, VA Pittsburgh Healthcare System), Joseph Conigliaro (0000-0001-6273-4024, University of Kentucky), Shawn L Fultz (VA Connecticut Healthcare System, corresponding author), Kristina Crothers (0000-0001-9702-0371, Yale New Haven Hospital, corresponding author), Linda Rabeneck (0000-0002-2375-0758, University of Toronto), Maria Rodriguez-Barradas, Maria C Rodriguez‐Barradas (0000-0003-2446-2667, Michael E. DeBakey VA Medical Center), Sharon Weissman (0000-0002-2854-5745, Yale New Haven Hospital, corresponding author), Sharon B Weissman, Kendall Bryant (0000-0002-0792-1449, University of Pittsburgh) |
| Year | 2006 |
| Volume | 44 |
| Issue | 8 |
| Pages | S52-S60 |
| Publication date | 2006-08-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Medical Care (JOURNAL) |
| Journal identifiers | ISSN: 0025-7079 • E-ISSN: 1537-1948 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/01.mlr.0000228003.08925.8c |
| PMID | 16849969 |
| OpenAlex | W2053178989 |
| Language | EN |
| Citations received | 20 |
| References cited | 35 |
BACKGROUND: Many people with human immunodeficiency (HIV) infection drink alcohol. We asked whether level of exposure to alcohol is associated with medical disease in a linear or nonlinear manner, whether the association depends upon the proximity of alcohol use, and whether it varies by source used to measure disease (chart review vs. ICD-9 Diagnostic Codes). METHODS: The Veterans Aging 3 Site Cohort Study (VACS 3) enrolled 881 veterans, 86% of all HIV-positive patients seen, at 3 VA sites from June 23, 1999, to July 28, 2000. To maximize the sensitivity for alcohol exposure, alcohol use was measured combining data from patient self-report, chart review, and ICD-9 codes. We assigned the greatest exposure level reported from any source. Alcohol use within the past 12 months was considered current. Data on comorbid and AIDS-defining medical diseases were collected via chart review and ICD-9 diagnostic codes. The association of alcohol use (level and timing) and disease was modeled only for diseases demonstrating > or =10% prevalence. Linearity was compared with nonlinearity of association using nested multivariate models and the likelihood ratio test. All multivariate models were adjusted for age, CD4 cell count, viral load, intravenous drug use, exercise, and smoking. RESULTS: Of 881 subjects enrolled, 866 (98%) had sufficient data for multivariate analyses, and 876 (99%) had sufficient data for comparison of chart review with ICD-9 Diagnostic Codes. Of the 866, 42 (5%) were lifetime abstainers; 247 (29%) were past drinkers; and 577 (67%) were current users. Among the 824 reporting past or current alcohol use, 341 (41%) drank in moderation, 192 (23%) drank hazardously, and 291 (35%) carried a diagnosis of abuse or dependence. ICD-9 codes showed limited sensitivity, but overall agreement with chart review was good for 15 of 20 diseases (kappa > 0.4). The following diseases demonstrated a > or =10% prevalence with both measures (hepatitis C, hypertension, diabetes, obstructive lung disease, candidiasis, and bacterial pneumonia). All of these were associated with alcohol use (P < 0.05). Hepatitis C, hypertension, obstructive lung disease, candidiasis, and bacterial pneumonia demonstrated linear associations with level of alcohol use (P < 0.03). Past alcohol use increased the risk of hepatitis C and diabetes after adjustment for level of exposure (P < 0.01). With the exception of candidiasis, the associations between level and timing of alcohol use were similar when measured by ICD-9 codes or by chart review. CONCLUSIONS: Past and current use of alcohol is common among those with HIV infection. Estimates of disease risk associated with alcohol use based upon ICD-9 Diagnostic Codes appear similar to those based upon chart review. After adjustment for level of alcohol exposure, past use is associated with similar (or higher) prevalence of disease as among current drinkers. Finally, level of alcohol use is linearly associated with medical disease. We find no evidence of a "safe" level of consumption among those with HIV infection
Cohort · Cohort study · Diagnosis code · Environmental health · Medical record · Multivariate analysis · Multivariate statistics · Population · Statistics · Veterans Affairs · Alcohol Consumption and Health Effects · HIV-related health complications and treatments · HIV/AIDS Research and Interventions · Internal Medicine · Medicine
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Alcohol Use and Antiretroviral Adherence Among Patients Living with HIV
Alcohol Use and Multimorbidity Among Individuals Living with HIV
Antiretroviral Adherence Among Rural Compared to Urban Veterans with HIV Infection in the United States
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Systematic Cultural Adaptation of Cognitive-Behavioral Therapy to Reduce Alcohol Use Among HIV-Infected Outpatients in Western Kenya
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Problematic Alcohol Use Among Individuals with HIV
Level of Alcohol Use Associated with HIV Care Continuum Targets in a National U.S. Sample of Persons Living with HIV Receiving Healthcare
Addressing the intersection between alcohol consumption and antiretroviral treatment
The effect of history of injection drug use and alcoholism on HIV disease progression
Geographic Access and Use of Infectious Diseases Specialty and General Primary Care Services by Veterans With HIV Infection
Off-Premise Alcohol Sales Policies, Drinking, and Sexual Risk Among People Living With HIV
Delayed Presentation for Human Immunodeficiency Virus (HIV) Care Among Veterans
The Veterans Affairs Healthcare System
Rural Residence Is Associated With Delayed Care Entry and Increased Mortality Among Veterans With Human Immunodeficiency Virus Infection
Alcohol Problems and Health Care Services Use in Human Immunodeficiency Virus (HIV)-Infected and HIV-Uninfected Veterans
Role of Alcohol in Determining Human Immunodeficiency Virus (HIV)-Relevant Outcomes
Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases
Problem drinking and medication adherence among persons with HIV infection
A simulation study of the number of events per variable in logistic regression analysis
A new method of classifying prognostic comorbidity in longitudinal studies
Comparison of Coding of Heart Failure and Comorbidities in Administrative and Clinical Data for Use in Outcomes Research
A Severity Classification System for Aids Hospitalizations
Comorbidity Measures for Use with Administrative Data
Validity of Using an Electronic Medical Record for Assessing Quality of Care in an Outpatient Setting
Veterans Aging Cohort Study (Vacs)
Validity of Procedure Codes in International Classification of Diseases, 9th revision, Clinical Modification Administrative Data
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| Unique citing works | 20 |
|---|---|
| Citations per year | 1 |
| Citation span | 2006 - 2020 (15) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 20 |