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An International Comparison of the Reliability and Responsiveness of the Duke Health Profile for Measuring Health-Related Quality of Life of Patients Treated With Alprostadil for Erectile Dysfunction

Bibliographic Data

ID9102992
AuthorsGeorge R Parkerson (Duke University Hospital, corresponding author), Richard J Willke, Ron D Hays (0000-0001-6697-907X, University of California, Los Angeles)
Year1999
Volume37
Issue1
Pages56-67
Publication date1999-01-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueMedical Care (JOURNAL)
Journal identifiersISSN: 0025-7079 • E-ISSN: 1537-1948
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/00005650-199901000-00009
PMID10413393
OpenAlexW2020632702
LanguageEN
Citations received5
References cited34

OBJECTIVES: It is important that health measures are both reliable and responsive to clinical change. The aim of this study was to assess the reliability and responsiveness of the physical, mental, and social health scales of the Duke Health Profile (DUKE). METHODS: Impotent males self-administered the Duke Health Profile before and during treatment with alprostadil for erectile dysfunction during a 19-month period. Subjects were 490 patients in the United States and 583 patients in 12 other countries. Each of the three basic Duke Health Profile scales has only five items, and each is heterogeneous because each measures more than one health concept. RESULTS: Cronbach's alpha reliability estimates were: physical health, 0.68 for United States and 0.64 for other countries; mental health, 0.62 and 0.52, respectively; and social health, 0.53 and 0.47, respectively. Alprostadil was expected to improve mental health primarily, and results of the study were consistent with this hypothesis. For example, at approximately 14 months from therapy onset, mental health improved for patients both in the United States (standardized response mean, SRM, = 0.17) and other countries (mean SRM = 0.30), whereas physical health worsened in the United States and was unchanged in other countries, and social health was unchanged in the United States and improved in other countries. Maximum responsiveness was shown for mental health in the other countries, where the mean standardized response means at four follow-ups during a 19-month period were 0.11, 0.21, 0.30, and 0.36. CONCLUSIONS: This study provides support for the responsiveness of the Duke Health Profile mental health scale

Cronbach's alpha · Erectile dysfunction · Health related quality of life · Mental health · Psychiatry · Psychometrics · Public health · Quality of life (healthcare) · Reliability (semiconductor) · SF-36 · Social determinants of health · Clinical Psychology · Forensic Toxicology and Drug Analysis · Hormonal and reproductive studies · Internal Medicine · Medicine · Nursing · Psychology · Sexual function and dysfunction studies · Gerontology

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Unique citing works5
Citations per year0,2
Citation span2001 - 2021 (21)
Citation velocityhistorical
Highly citedNo
Citation typesNeutral: 4

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