Clinical Predictors of Functioning in Persons with Acquired Immunodeficiency Syndrome
Bibliographic Data
| ID | 9103243 |
|---|---|
| Authors | Ira B Wilson (0000-0002-0246-738X, Tufts Medical Center), Paul D Cleary (0000-0001-7527-4354, Harvard University) |
| Year | 1996 |
| Volume | 34 |
| Issue | 6 |
| Pages | 610-623 |
| Publication date | 1996-06-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Medical Care (JOURNAL) |
| Journal identifiers | ISSN: 0025-7079 • E-ISSN: 1537-1948 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/00005650-199606000-00010 |
| PMID | 8656726 |
| OpenAlex | W2326976374 |
| Language | EN |
| Citations received | 13 |
| References cited | 49 |
To help clinicians better assess and treat functional disabilities in persons with acquired immunodeficiency syndrome (AIDS), the authors estimate empirical relations among biologic and physiologic variables, symptoms, and physical functioning in persons with AIDS. The sample of 305 persons with AIDS for this cross-sectional analysis came from three sites in Boston, Massachusetts: a hospital-based group practice, a human immunodeficiency virus clinic at a city hospital, and a staff-model health maintenance organization. Physical functioning, 10 AIDS-specific symptoms, and mental health were assessed by interview. Clinical diagnoses, comorbidities, health habits such as smoking, laboratory results, and selected medication use were assessed by chart review. Significant predictors of physical functioning P < 0.01, R2 = .58) in a multivariable regression model included energy/fatigue, neurologic symptoms, fever symptoms, a lower hemoglobin level, and current non-pneumonia bacterial infection. Ninety-six percent of the explained variance in physical functioning was accounted for by three symptom complexes: energy/fatigue, neurologic symptoms, and fever symptoms. Significant predictors of energy/fatigue in multivariable models included poorer mental health, lower white blood cell count, longer time since diagnosis, and weight loss (P < 0.01, R2 =.36). Significant predictors of neurologic symptoms included poorer mental health, weight loss, and no zidovudine use (P < 0.001, R2 = .30). Predictors of fever symptoms included poorer mental health, no zidovudine use, weight loss, and history of asthma or chronic obstructive pulmonary disease (P < 0.05, R2 = .25). In conclusion, symptom reports were strong predictors of physical functioning. Poorer mental health and weight loss were correlated consistently with worse symptoms, and not using zidovudine was correlated with worse neurologic and fever symptoms. These variables, and the others the authors identified, may represent mutable determinants of physical functioning in persons with AIDS, and potential targets for specific clinical interventions
Anxiety · Asthma · Depression (economics) · Disease · Human immunodeficiency virus (HIV) · Mental health · Obesity · Physical therapy · Pneumonia · Psychiatry · Viral disease · Weight loss · Zidovudine · HIV-related health complications and treatments · HIV/AIDS Research and Interventions · Immunology · Internal Medicine · Medicine · Pneumocystis jirovecii pneumonia detection and treatment
Clinical Importance of Provider-Reported HIV Symptoms Compared With Patient-Report
Understanding the relationships between health outcomes in generalized anxiety disorder clinical trials
Putting Wilson and Cleary to the Test
Sleep quality and health-related quality of life in HIV-infected African-American women of childbearing age
Health-related quality of life in patients with human immunodeficiency virus infection in the United States
Development and validation of a self-completed HIV symptom index
A further investigation of health-related quality of life over time among men with HIV infection in the Haart era
Assessing a conceptual framework of health-related quality of life in a HIV/Aids population
Self-Management Strategies for Coping with Adverse Symptoms in Persons Living with HIV with HIV Associated Non-Aids Conditions
Efficacy, Use, and Usability of the VIP-Hana App for Symptom Self-management in PLWH with Hana Conditions
Measuring validity of self-reported symptoms among people with HIV
Associations of clinical parameters with health-related quality of life in hospitalized persons with HIV disease
Social networks and mental health among people living with human immunodeficiency virus (HIV) in Johannesburg, South Africa
Who should measure quality of life, the doctor or the patient?
The role of health care providers and significant others in evaluating the quality of life of patients with chronic disease
Barriers to the Use of Health Status Measures in Clinical Investigation, Patient Care, and Policy Research
Ongoing Assessment of Health Status in Patients with Diabetes Mellitus
Benefits and Obstacles of Health Status Assessment in Ambulatory Settings
The Quality of Well-Being Scale
Some Methodological Lessons for Surveys of Persons With Aids
Factors Influencing the Diagnosis of Mental Disorder Among Primary Care Patients
Health-Related Quality of Life in Persons with Acquired Immune Deficiency Syndrome
| Citations per year | 0.48 |
|---|---|
| Citation span | 1999 - 2021 (23) |
| Highly cited | No |