Comparison of Meta-Analytic Results of Indirect, Direct, and Combined Comparisons of Drugs for Chronic Insomnia in Adults

BACKGROUND: Our Center recently conducted a systematic review of the manifestations and management of chronic insomnia in adults. The efficacy and safety of benzodiazepines and nonbenzodiazepines, relative to placebo, were compared indirectly. OBJECTIVES: Determine how the results of indirect comparisons made in the review compare with the results of direct comparisons, as well as with estimates derived from Bayesian mixed treatment comparisons. Establish general appropriateness of the use of results of indirect or mixed treatment comparisons. METHODS: Treatments were compared using frequentist direct, indirect, and combined methods, as well as Bayesian direct and mixed methods. RESULTS: Estimates for comparisons tended to be clinically and statistically similar across methods. Estimates obtained through indirect comparisons were not biased and were similar to those obtained through direct analysis. CONCLUSIONS: Results of indirect comparisons made in the review, accurately reflected the current evidence. Frequentist and Bayesian methods of analysis of indirect comparisons should be considered when performing meta-analyses

Chronic insomnia · Insomnia · Meta-analysis · Psychiatry · Sleep disorder · Internal Medicine · Medicine · Psychology · Sleep and related disorders · Sleep and Wakefulness Research · Treatment of Major Depression

• Emerging Methods in Comparative Effectiveness and Safety

  Kathleen N Lohr•Medical Care•2007

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