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Estimating Subgroup Effects Using the Propensity Score Method

A Practical Application in Outcomes Research

Bibliographic Data

ID9103525
AuthorsHester V Eeren (0000-0003-0624-9950, De Viersprong, corresponding author), Marieke D Spreeuwenberg (Maastricht University), Anna Bartak (University of Amsterdam), Mark de Rooij (0000-0001-7308-6210, Leiden University), Jan J V Busschbach (0000-0002-8602-0381, De Viersprong, corresponding author)
Year2015
Volume53
Issue4
Pages366-373
Publication date2015-04-01
Open AccessNo
TypeARTICLE
VenueMedical Care (JOURNAL)
Journal identifiersISSN: 0025-7079 • E-ISSN: 1537-1948
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/mlr.0000000000000325
PMID25738381
OpenAlexW2319588407
LanguageEN
Citations received1
References cited39

OBJECTIVE: Our aim was to demonstrate the feasibility of the univariate and generalized propensity score (PS) method in subgroup analysis of outcomes research. METHODS: First, to estimate subgroup effects, we tested the performance of 2 different PS methods, using Monte Carlo simulations: (1) the univariate PS with additional adjustment on the subgroup; and (2) the generalized PS, estimated by crossing the treatment options with a subgroup variable. The subgroup effects were estimated in a linear regression model using the 2 PS adjustments. We further explored whether the subgroup variable should be included in the univariate PS. Second, the 2 methods were compared using data from a large effectiveness study on psychotherapy in personality disorders. Using these data we tested the differences between short-term and long-term treatment, with the severity of patients' problems defining the subgroups of interest. RESULTS: The Monte Carlo simulations showed minor differences between both PS methods, with the bias and mean squared error overall marginally lower for the generalized PS. When considering the univariate PS, the subgroup variable can be excluded from the PS estimation and only adjusted for in the outcome equation. When applied to the psychotherapy data, the univariate and generalized PS estimations gave similar results. CONCLUSION: The results support the use of the generalized PS as a feasible method, compared with the univariate PS, to find certain subgroup effects in nonrandomized outcomes research

Confidence interval · Econometrics · Monte Carlo method · Multivariate analysis · Multivariate statistics · Propensity score matching · Statistics · Subgroup analysis · Univariate · Univariate analysis · Advanced Causal Inference Techniques · Mathematics · Medicine · Psychological Testing and Assessment · Psychometric Methodologies and Testing

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Citations per year0.25
Citation span2022 - 2022 (1)
Highly citedNo

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