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Pharmacy-based Interventions to Reduce Primary Medication Nonadherence to Cardiovascular Medications

Bibliographic Data

ID9103876
AuthorsMichael A Fischer (0000-0002-4685-164X, Brigham and Women's Hospital, corresponding author), Niteesh K Choudhry (0000-0001-7719-2248, Brigham and Women's Hospital, corresponding author), Katsiaryna Bykov (0000-0003-3336-5412, Brigham and Women's Hospital, corresponding author), Gregory Brill (Brigham and Women's Hospital, corresponding author), Gregory Bopp, Gregory P Bopp (0000-0002-0050-7122, CVS Health (United States)), Aaron M Wurst (CVS Health (United States)), William H Shrank (CVS Health (United States), corresponding author)
Year2014
Volume52
Issue12
Pages1050-1054
Publication date2014-12-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueMedical Care (JOURNAL)
Journal identifiersISSN: 0025-7079 • E-ISSN: 1537-1948
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/mlr.0000000000000247
PMID25322157
OpenAlexW2064534742
LanguageEN
Citations received1
References cited15

BACKGROUND: Primary medication nonadherence (PMN) occurs when patients do not fill new prescriptions. Interventions to reduce PMN have not been well described. OBJECTIVES: To determine whether 2 pharmacy-based interventions could decrease PMN. DESIGN: Two sequential interventions with a control group were evaluated after completion. The automated intervention began in 2007 and consisted of phone calls to patients on the third and seventh days after a prescription was processed but remained unpurchased. The live intervention began in 2009 and used calls from a pharmacist or technician to patients who still had not picked up their prescriptions after 8 days. SUBJECTS: Patients with newly prescribed cardiovascular medications received at CVS community pharmacies. Patients with randomly selected birthdays served as the control population. MEASURES: Patient abandonment of new prescription, defined as not picking up medications within 30 days of initial processing at the pharmacy. RESULTS: The automated intervention included 852,612 patients and 1.2 million prescriptions, with a control group of 9282 patients and 13,178 prescriptions. The live intervention included 121,155 patients and 139,502 prescriptions with a control group of 2976 patients and 3407 prescriptions. The groups were balanced by age, sex, and patterns of prior prescription use. For the automated intervention, 4.2% of prescriptions were abandoned in the intervention group and 4.5% in the control group (P>0.1), with no significant differences for any individual classes of medications. The live intervention was used in a group that had not purchased prescriptions after 8 days and thus had much higher PMN. In this setting 36.9% of prescriptions were abandoned in the intervention group and 41.7% in the control group, a difference of 4.8% (P 0.1). CONCLUSIONS: Automated reminder calls had no effect on PMN. Live calls from pharmacists decreased antihypertensive PMN significantly, although many patients still abandoned their prescriptions

Family medicine · Intervention (counseling) · Medical prescription · Pharmacist · Population · Psychological intervention · Heart Failure Treatment and Management · Medication Adherence and Compliance · Medicine · Nursing · Pharmaceutical Practices and Patient Outcomes · Pharmacy

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Unique citing works1
Citations per year0,25
Citation span2022 - 2022 (1)
Citation velocityhistorical
Highly citedNo
Citation typesNeutral: 1
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