Microcephaly measurement in adults and its association with clinical variables

Bibliographic Data

ID9259337
AuthorsNicole Rezende da Costa (0000-0002-8420-1680, Universidade de São Paulo), Livia Mancine (0000-0002-4123-4861, Instituto Federal Goiano), Roberto Salvini (0000-0001-8889-6654, Universidade Federal de Goiás), Juliana de Melo Teixeira (0000-0001-7731-9464, Universidade Federal de Goiás), Roberta Diehl Rodríguez (0000-0002-6544-7861, Universidade de São Paulo), Renata Elaine Paraizo Leite (0000-0002-5878-398X, Universidade de São Paulo), Camila Nascimento (0000-0002-8170-7635, Universidade de São Paulo), Carlos Augusto Pasqualucci (0000-0001-6608-2473, Universidade de São Paulo), Ricardo Nitrini (0000-0002-5721-1525, Universidade de São Paulo), Wilson Jacob-Filho (0000-0003-2290-4492, Universidade de São Paulo), Beny Lafer (0000-0002-6132-9999, Universidade de São Paulo), Lea Tenenholz Grinberg (0000-0002-6809-0618, Universidade de São Paulo), Claudia Kimie Suemoto (0000-0001-6243-0530, Universidade de São Paulo), Pâmela Vieira Nunes (0000-0001-5323-2110, Universidade de São Paulo)
Year2022
Volume56
Pages38
Publication date2022-05-18
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueRevista de Saúde Pública (JOURNAL)
Journal identifiersISSN: 0034-8910 • E-ISSN: 0034-8910
PublisherUniversidade de São Paulo. Agência de Bibliotecas e Coleções Digitais (PUBLISHER)
DOI10.11606/s1518-8787.2022056004175
PMID35649085
OpenAlexW4281724512
LanguageEN
Citations received3
References cited3

OBJECTIVE: To establish a microcephaly cut-off size in adults using head circumference as an indirect measure of brain size, as well as to explore factors associated with microcephaly via data mining. METHODS: In autopsy studies, head circumference was measured with an inelastic tape placed around the skull. Total brain volume was also directly measured. A linear regression was used to determine the association of head circumference with brain volume and clinical variables. Microcephaly was defined as head circumference that were two standard deviations below the mean of significant clinical variables. We further applied an association rule mining to find rules associating microcephaly with several sociodemographic and clinical variables. RESULTS: In our sample of 2,508 adults, the mean head circumference was 55.3 ± 2.7cm. Head circumference was related to height, cerebral volume, and sex (p 0.5 with an informant questionnaire on cognitive decline in the elderly (IQCODE) ≥ 3.4 (confidence: 100% and lift: 5.6), between microcephaly and a CDR > 0.5 with age over 70 years (confidence: 42% and lift: 2.4), and microcephaly and males (confidence: 68.1% and lift: 1.3). CONCLUSION: Head circumference was related to cerebral volume. Due to its low cost and easy use, head circumference can be used as a screening test for microcephaly, adjusting it for gender and height. Microcephaly was associated with dementia at old age

Biology · Birth weight · Brain size · Confidence interval · Dementia · Disease · Head circumference · Magnetic resonance imaging · Microcephaly · Pregnancy · Radiology · Alzheimer's disease research and treatments · Dementia and Cognitive Impairment Research · Epilepsy research and treatment · Internal Medicine · Medicine · Pediatrics