Resting Hypothalamic–Pituitary–Adrenal Axis Activity in Childhood Following Maltreatment
A Meta‐Analysis
Bibliographic Data
| ID | 9685940 |
|---|---|
| Authors | Steven J Holochwost (0000-0003-3801-1840, Department of Psychology, Lehman College City University of New York, Gillet Hall Bronx New York USA, corresponding author), Lindsay A Gomes (Department of Psychology and Neuroscience University of North Carolina at Chapel Hill Chapel Hill North Carolina USA), Amanda Wylie (0000-0002-9354-5848, Department of Psychology and Neuroscience University of North Carolina at Chapel Hill Chapel Hill North Carolina USA), Jacek Kolacz (0000-0002-4503-068X, Department of Psychiatry and Behavioral Health College of Medicine, Ohio State University, Columbus, OH Columbus Ohio USA) |
| Year | 2025 |
| Volume | 67 |
| Issue | 2 |
| Pages | e70022-e70022 |
| Publication date | 2025-03-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Developmental Psychobiology (JOURNAL) |
| Journal identifiers | ISSN: 0012-1630 • E-ISSN: 1098-2302 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/dev.70022 |
| PMID | 40007054 |
| OpenAlex | W4407987563 |
| Language | EN |
| References cited | 118 |
The experience of maltreatment in childhood is associated with poorer developmental and health outcomes. This may be explained by the capacity for maltreatment to dysregulate stress‐responsive neurophysiological systems, including the hypothalamic–pituitary–adrenal (HPA) axis. This study presents the results of the first meta‐analysis that examines the association between maltreatment and resting HPA‐axis activity in children and the role of “third variables” in accounting for observed heterogeneity in this association. Analyses of 18 studies, including N = 2216 children, indicated that although there was no difference in resting HPA‐axis activity between children who had been maltreated and those who had not (standardized mean difference [SMD] = 0.04), there was substantial heterogeneity in the association between maltreatment and HPA‐axis activity across studies ( I 2 = 58.60%, p = 0.001). Further analyses revealed that the association between maltreatment and resting HPA‐axis activity was contingent upon the source of information regarding maltreatment ( B = 0.33, p = 0.002) and the degree to which maltreated and comparison groups differed in their socioeconomic status ( B = 0.39, p = 0.037)
Hormone · Hypothalamic–pituitary–adrenal axis · Meta-analysis · Child Abuse and Trauma · Endocrinology · Internal Medicine · Maternal Mental Health During Pregnancy and Postpartum · Medicine · Psychology · Stress Responses and Cortisol
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| Citation velocity | historical |
|---|---|
| Highly cited | No |