Maternal Gestational Diabetes Mellitus (GDM) Moderates the Association Between Birth Weight and EEG Power in Healthy Term‐Age Newborns

Bibliographic Data

ID9685978
AuthorsLauren C Shuffrey (0000-0003-3631-5971, Department of Child and Adolescent Psychiatry NYU Grossman School of Medicine New York New York USA, corresponding author), Nicolò Pini (0000-0002-0839-6033, Department of Psychiatry Columbia University Medical Center New York New York USA), Han Mei (0009-0009-4777-383X, Department of Psychiatry Columbia University Medical Center New York New York USA), Cynthia Rodriguez (0000-0002-4724-0277, Division of Developmental Neuroscience New York State Psychiatric Institute New York New York USA), Lissete A Gimenez (0000-0003-4142-5665, Division of Developmental Neuroscience New York State Psychiatric Institute New York New York USA), Jennifer R Barbosa (Department of Psychiatry Columbia University Medical Center New York New York USA), Daianna J Rodriguez (Division of Developmental Neuroscience New York State Psychiatric Institute New York New York USA), Yael Rayport (0000-0002-0021-3706, Department of Psychiatry Columbia University Medical Center New York New York USA), Ayesha Sania (0000-0002-6445-9481, Department of Psychiatry Columbia University Medical Center New York New York USA), Catherine Monk (0000-0001-7827-2602, Department of Psychiatry Columbia University Medical Center New York New York USA), William P Fifer (0000-0002-6936-9303, Department of Psychiatry Columbia University Medical Center New York New York USA)
Year2025
Volume67
Issue1
Pagese70014-e70014
Publication date2025-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueDevelopmental Psychobiology (JOURNAL)
Journal identifiersISSN: 0012-1630 • E-ISSN: 1098-2302
PublisherWiley (PUBLISHER • GB)
DOI10.1002/dev.70014
PMID39740790
OpenAlexW4405931586
LanguageEN
References cited59

Gestational diabetes mellitus (GDM) affects around 10% of pregnancies in the United States and has been linked to neurodevelopmental sequelae in children. However, there is a paucity of studies investigating early‐life neural markers in GDM‐exposed infants. This study examined the association of GDM with relative EEG power among healthy term‐age neonates collected during natural sleep. Participants included a diverse cohort of 101 mothers (45% multiracial, 25% Black, and 69% Hispanic or Latina) and their infants (gestational age at birth M age = 39.0 ± 0.95; 46.5% female). We did not observe the main effect of GDM on infant relative EEG power. Our post hoc analyses revealed a significant interaction effect between GDM and infant birth weight on relative EEG power in active sleep. Among GDM‐exposed neonates, increased birth weight was associated with increased relative theta EEG power and decreased relative beta and gamma EEG power across multiple electrode regions. Among non‐GDM‐exposed infants, increased birth weight was associated with decreased relative theta EEG power and increased relative beta and gamma EEG power across multiple electrode regions. Our findings suggest that alterations in fetal growth may serve as either an indirect marker or pathway through which GDM influences the developing fetal brain

Biology · Birth weight · Cohort · Confidence interval · Electroencephalography · Fetus · Gestation · Gestational age · Gestational diabetes · Obstetrics · Pregnancy · Psychiatry · Relative risk · Infant Development and Preterm Care · Internal Medicine · Medicine · Neonatal and fetal brain pathology · Neuroscience of respiration and sleep · Pediatrics

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