Longitudinal effects of prenatal alcohol exposure on visual neurodevelopment over infancy

Bibliographic Data

ID9786215
AuthorsEmma T Margolis (0000-0002-2036-8078, Northeastern University, corresponding author), Lauren Davel (University of Cape Town), Niall J Bourke (0000-0001-6478-1430, King's College London), Cara Bosco (Northeastern University), Michal R Zieff (0000-0001-9352-9947, University of Cape Town), Alexa D Monachino (0000-0002-1158-3948, Northeastern University), Thandeka Mazubane (University of Cape Town), Simone R Williams (0000-0002-1023-5327, University of Cape Town), Marlie Miles (0009-0004-7526-8885, University of Cape Town), Chloë A Jacobs (0009-0003-0850-4625, University of Cape Town), Sadeeka Williams (0009-0001-3453-5105, University of Cape Town), Layla Bradford (University of Cape Town), Candice Knipe (University of Cape Town), Zamazimba Madi (University of Cape Town), Bokang Methola (University of Cape Town), Tembeka Mhlakwaphalwa (University of Cape Town), Nwabisa Mlandu (0000-0002-3483-2898, University of Cape Town), Khanyisa Nkubungu (University of Cape Town), Zayaan Goolam Nabi (University of Cape Town), Tracy Pan (0000-0001-5710-8096, University of Cape Town), Reese Samuels (University of Cape Town), Nicolò Pini (0000-0002-0839-6033, Columbia University Irving Medical Center), Vanja Klepac-Ceraj, Vanja Klepac‐Ceraj (0000-0001-5387-5706, Wellesley College), William P Fifer (0000-0002-6936-9303, Columbia University Irving Medical Center), Daniel C Alexander (0000-0003-2439-350X, University College London), Derek K Jones (0000-0003-4409-8049, Cardiff University), William (0000-0003-4299-1941, University of Cape Town), Steve C R Williams, Dima Amso (0000-0001-6798-4698, Columbia University), Kirsten A Donald (0000-0002-0276-9660, University of Cape Town), Laurel J Gabard-Durnam, Laurel J Gabard‐Durnam (0000-0002-4564-8068, Northeastern University)
Year2024
Volume60
Issue9
Pages1673-1698
Publication date2024-09-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueDevelopmental Psychology (JOURNAL)
Journal identifiersISSN: 0012-1649 • E-ISSN: 1939-0599
PublisherAmerican Psychological Association (APA) (PUBLISHER)
DOI10.1037/dev0001727
PMID38512192
OpenAlexW4393039777
LanguageEN
Citations received1

Prenatal alcohol exposure (PAE) affects neurodevelopment in over 59 million individuals globally. Prior studies using dichotomous categorization of alcohol use and comorbid substance exposures provide limited knowledge of how prenatal alcohol specifically impacts early human neurodevelopment. In this longitudinal cohort study from Cape Town, South Africa, PAE is measured continuously-characterizing timing, dose, and drinking patterns (i.e., binge drinking). High-density electroencephalography (EEG) during a visual-evoked potential (VEP) task was collected from infants aged 8 to 52 weeks with prenatal exposure exclusively to alcohol and matched on sociodemographic factors to infants with no substance exposure in utero. First trimester alcohol exposure related to altered timing of the P1 VEP component over the first 6 months postnatally, and first trimester binge drinking exposure altered timing of the P1 VEP components such that increased exposure was associated with longer VEP latencies while increasing age was related to shorter VEP latencies ( n = 108). These results suggest alcohol exposure in the first trimester may alter visual neurodevelopmental timing in early infancy. Exploratory individual-difference analysis across infants with and without PAE tested the relation between VEP latencies and myelination for a subsample of infants with usable magnetic resonance imaging (MRI) T1w and T2w scans collected at the same time point as EEG ( n = 47). Decreased MRI T1w/T2w ratios (an indicator of myelin) in the primary visual cortex ( n = 47) were linked to longer P1 VEP latencies. Results from these two sets of analyses suggest that prenatal alcohol and postnatal myelination may both separately impact VEP latency over infancy. (PsycInfo Database Record (c) 2024 APA, all rights reserved)

Audiology · Binge drinking · Developmental psychology · Electroencephalography · Evoked potential · Fetal alcohol syndrome · Fetus · In utero · Injury prevention · Longitudinal study · Poison control · Pregnancy · Prenatal alcohol exposure · Psychiatry · Birth, Development, and Health · Medicine · Neonatal and fetal brain pathology · Prenatal Substance Exposure Effects · Psychology

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