Population Genetics and Forensic Efficiency of 30 InDel Markers in Four Chinese Ethnic Groups Residing in Sichuan

Bibliographic Data

ID13119772
AuthorsFei Wang (0000-0003-0860-6317, West China Medical Center of Sichuan University), Guanglin He (0000-0002-6614-5267, West China Medical Center of Sichuan University), Zheng Wang (0000-0003-0758-2202, West China Medical Center of Sichuan University), Mengge Wang (0000-0002-3673-1855, West China Medical Center of Sichuan University), Jing Liu (0000-0002-0965-0320, West China Medical Center of Sichuan University), Xing Zou (0009-0006-8632-1770, West China Medical Center of Sichuan University), Shouyu Wang (0000-0002-6082-2028, West China Medical Center of Sichuan University), Mengyuan Song (0000-0002-6956-4352, West China Medical Center of Sichuan University), Ziwei Ye (0000-0002-3658-7179, West China Medical Center of Sichuan University), Mingkun Xie (0000-0003-1696-7470, West China Medical Center of Sichuan University), Yiping Hou (0000-0003-4254-2388, West China Medical Center of Sichuan University, corresponding author)
Year2020
Volume7
Issue3
Pages498-502
Publication date2020-04-21
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueForensic Sciences Research (JOURNAL)
Journal identifiersISSN: 2471-1411 • E-ISSN: 2096-1790
PublisherTaylor & Francis (PUBLISHER • GB)
DOI10.1080/20961790.2020.1737470
PMID36353334
OpenAlexW3017542428
LanguageEN
Citations received2
References cited37

Sichuan Province is located at the transitional junction regions of the Qinghai-Tibet Plateau and the low-altitude plains. It also serves as the corridor of Sino-Tibetan-speaking population migration and expansion since neolithic expansion of Proto-Tibeto-Burman populations from Middle/Upper Yellow River during Majiayao period (3300-2000 BC). However, the population structure and the corresponding genetic diversity of forensic-related markers in this region remain unclear. Thus, we genotyped 30 insertion-deletion (InDel) markers in 444 samples from four ethnic groups (Han, Tibetan, Hui and Yi) from Sichuan Province using the Investigator ® DIPplex kit to explore the characteristics of population genetics and forensic genetic focuses. All the loci were found to be in Hardy-Weinberg Equilibrium (HWE) after applying a Bonferroni correction and no pairwise loci showed prominent linkage disequilibrium. The combined matching probability (CMP) and the combined power of discrimination (CPD) are larger than 1.8089 × 10 -11 and 0.99999999995, respectively. Principal component analysis, multi-dimensional scaling plots and Neighbour-Joining tree among 65 worldwide populations indicated that Sichuan Hui and Han are genetically close to Hmong-Mien and Tai-Kadai-speaking populations, and Sichuan Tibetan and Yi bear a strong genetic affinity with Tibeto-Burman-speaking populations. The model-based genetic structure further supports the genetic affinity between the studied populations and linguistically close populations.Key PointsForensic parameters of 30 insertion-deletions (InDels) in 444 individuals from four populations are reported, which showed abundant genetic affinity and diversity among populations and high value in personal identification.Genetic similarities existed between the studied populations and ethnically, linguistically close populations.Sichuan Hui and Han are genetically close to Hmong-Mien and Tai-Kadai-speaking populations.Sichuan Tibetan and Yi bear a strong genetic affinity with Tibeto-Burman-speaking populations

Allele · Allele frequency · Ancestry-informative marker · Biology · Evolutionary biology · Gene · Genetic diversity · Genetic relationship · Genotype · Haplotype · Indel · Linkage Disequilibrium · Population · Single-nucleotide polymorphism · Demography · Forensic and Genetic Research · Genetic diversity and population structure · Molecular Biology Techniques and Applications · Genetics