Anthropometric and sociodemographic variables, but not preconception or prenatal maternal nutrition supplementation, predict neurodevelopment in offspring of the ‘Women First’ trial
Bibliographic Data
Multiple factors influence infant and child neurodevelopment in low resource settings. In offspring of participants in the preconception maternal nutrition trial, Women First (WF), we examined the impact of providing a preconception (Arm 1) or prenatal (Arm 2) nutrient supplement (compared to controls, Arm 3) on neurodevelopmental outcomes at 24 months; predictors of neurodevelopment scores; and associations of infant anthropometrics with neurodevelopmental scores. Follow-up visits for anthropometry were conducted at 6-, 12-, 18- and 24-month of age. At 24-months, in a randomized subset, the Bayley Scales of Infant Development, 3rd edition (BSID-III), including cognitive, motor and social-emotional subscales, and the Family Care Indicators (FCI) questionnaire, assessing family and home environment, were completed. Multiple covariates (intervention arm, site, maternal sociodemographic characteristics, FCI subscales, birthweight and 6-24 months' change in anthropometry z-scores, (e.g., ΔLAZ 6-2 4 ) were evaluated by linear regression to predict BSID-III outcomes and to assess associations of anthropometric changes with BSID-III scores. The analysis consisted of 1386 infants (n = 441, 486, 459 for Arms 1, 2 and 3, respectively). None of the domain-specific BSID-III subscale scores differed by maternal intervention arm. Four covariates significantly predicted (p ≤ 0.01) all 3 BSID-III subscales: secondary maternal education, ΔLAZ 6 - 24 , birthweight >2500 g, and FCI play materials. Linear growth was associated with all domains of neurodevelopment. The results underscore the multi-dimensional aspects of child development represented by the nurturing care framework, including prenatal maternal nutrition, post-natal growth, maternal education for responsive caregiving and opportunities for early learning
Anthropometry · Bayley Scales of Infant Development · Child development · Cognition · Environmental health · Offspring · Population · Pregnancy · Prenatal care · Psychiatry · Psychomotor learning · Randomized controlled trial · Child Nutrition and Feeding Issues · Child Nutrition and Water Access · Infant Development and Preterm Care · Medicine · Pediatrics
Use of Family Care Indicators and Their Relationship with Child Development in Bangladesh
The Role of Nutrition in Brain Development
Linear Growth and Child Development in Low- and Middle-Income Countries
Before the beginning
Nutrition and brain development in early life
Early childhood development coming of age
The principles of Nurturing Care promote human capital and mitigate adversities from preconception through adolescence
Early childhood growth and cognitive outcomes
Anthropometric and sociodemographic variables, but not preconception or prenatal maternal nutrition supplementation, predict neurodevelopment in offspring of the ‘Women First’ trial
Infant and young child feeding indicators are positively associated with length and family care indicators in the children of the Women First trial participants
Improved first trimester maternal iodine status with preconception supplementation
Small-quantity lipid-based nutrient supplements for children age 6–24 months
Developmental science and the media
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,5 |
| Citation span | 2024 - 2024 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |