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Saving Little Lives Minimum Care Package Interventions in 290 Public Health Facilities in Ethiopia

Protocol for a Non-Randomized Stepped-Wedge Cluster Implementation Trial

Bibliographic Data

ID15712482
AuthorsAmera Seifu (0000-0002-6833-9823, Addis Ababa University, corresponding author), Abebe Gebremaraim Gobezayehu (Ethiopian Civil Service University), Mekdes Shifeta Argaw (Hawassa University), Araya Abrha Medhanyie (0000-0002-9328-684X, Mekelle University), Damen Hailemariam (Addis Ababa University), Bezaye Nigussie Kassahun (Hawassa University), Selamawit Asfaw Beyene (Mekelle University), Selemawit Asfaw Beyene (0000-0003-2595-5885, Mekelle University), Henok Tadele (0000-0002-9400-6563, Addis Ababa University), Lamesgin Alamineh Endalamaw (0000-0002-3293-9237, Ethiopian Civil Service University), Abebech Demissie Aredo (0009-0004-2985-7240, Addis Ababa University), Znabu Hadush Kahsay (0000-0003-1242-4508, Mekelle University), Znbau Hadush Kahsay (Mekelle University), Kehabtimer Shiferaw Kotiso (0000-0002-4195-0243, African Society for Laboratory Medicine), Akalewold Alemayehu (0000-0002-6448-6092, Hawassa University), Mulusew Lijalem Belew (0009-0003-0033-9450, Ethiopian Civil Service University), Amanuel Hadgu Berhe (0000-0003-3038-9638, Mekelle University), Simret Niguse Weldebirhan (Mekelle University), Asrat Dimtse (Addis Ababa University), Mesay Hailu Dangisso (0000-0003-1245-8839, Ethiopian Public Health Institute), Samson Yohannes Amare (0000-0002-5425-1126, Mekelle University), Yayeh Negash (United Nations Children's Fund), Abrham Tariku (Government of Ethiopia), John Cramer (Emory University), Siren Rettedal (0000-0002-4305-141X, Stavanger University Hospital), Abebe Bekele (0000-0003-0018-9096, Oromiyaa Regional Health Bureau), Fisseha Ashebir Gebregizabher (Mekelle University), Fisseha Ashebir (0000-0002-1405-0047, Tigray Regional Health Bureau, Mekelle P.O. Box 07, Ethiopia), Selamawit Mengesha Bilal (Hawassa University), Meseret Zelalem Tadesse (Government of Ethiopia), Dereje Duguma (Government of Ethiopia)
Year2026
Volume13
Issue2
Pages187-187
Publication date2026-01-29
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueChildren (JOURNAL)
Journal identifiersISSN: 2227-9067 • E-ISSN: 2227-9067
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/children13020187
PMID41749543
OpenAlexW7126059122
LanguageEN
Citations received1
References cited13

A non-randomized stepped-wedge trial will be conducted to evaluate the impact of implementing the SLL MCP interventions. Quantitative evaluation data will be collected from 36 primary hospitals, selected from 206 primary hospitals across four regions, receiving the interventions. An independent evaluation research assistant will be deployed in each of the hospitals to collect data using Open Data Kit (ODK) through interviewing mothers before discharge, on the 29th day of life if discharged, and reviewing medical records. A mixed-method, cross-sectional formative assessment will be conducted prior to implementation, employing quantitative facility assessment and qualitative interviews with mothers, healthcare providers, and facility managers. This will be followed by continuous program learning assessment once implementation begins. Descriptive data will be presented using numbers, percentages, tables, and graphs. Regression modeling and generalized estimating equations (GEEs) will be used to estimate the impact of the SLL MCP interventions. Qualitative data will be gathered through in-depth interviews, digitally recorded, transcribed, and thematically analyzed using ATLAS.ti Version 7.5 software to assess facility readiness, barriers, and enablers of implementing the SLL MCP interventions. Expected Outcome: We hypothesize that achieving 80% coverage of the SLL MCP interventions among eligible neonates will result in a 35% reduction in neonatal mortality at implementation facilities

Checklist · Cluster (spacecraft · Data collection · Formative assessment · Health care · Interview · Protocol (science · Psychological intervention · Qualitative property · Global Maternal and Child Health · Infant Development and Preterm Care · Neonatal Respiratory Health Research

  • Readiness to Provide Neonatal Care Services in 208 Ethiopian Hospitals Prior to Implementation of the Saving Little Lives Program

    Open Access•Lamesgin Alamineh Endalamaw, Amera Seifu et al.•Children•2026

  • A systematic review of the use of the Consolidated Framework for Implementation Research

    Open Access•M Alexis Kirk, Caitlin Kelley et al.•Implementation Science•2015

  • The stepped wedge cluster randomised trial

    Open Access•Karla Hemming, Timothy Haines et al.•BMJ•2015

  • National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000

    Open Access•Hannah Blencowe, Julia Krasevec et al.•The Lancet Global Health•2019

  • Every Newborn

    Open Access•Joy Elizabeth Lawn, Hannah Blencowe et al.•The Lancet•2014

  • Maternal and child undernutrition and overweight in low-income and middle-income countries

    Open Access•Robert E Black, Cesar G Victora et al.•The Lancet•2013

  • Scaling up Kangaroo Mother Care in Ethiopia and India

    Open Access•Prem Mony, Prem K Mony et al.•BMJ Global Health•2021

Unique citing works1
Citations per year1
Citation span2026 - 2026 (1)
Citation velocitycurrent
Highly citedNo
Citation typesNeutral: 1
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