Study on optimisation of extraction process of Tanshinone IIA and its mechanism of induction of gastric cancer SGC7901 cellapoptosis
Bibliographic Data
| ID | 20346258 |
|---|---|
| Authors | Juan Hou (0000-0002-3960-2696, Central South University), Junyu He (0000-0003-1873-3125, Central South University), Xin Jin (0000-0003-4590-5834, Central South University), Tao Hu (0000-0001-7893-096X, Central South University), Yu Zhang (0000-0002-0059-270X, Central South University) |
| Year | 2013 |
| Volume | 10 |
| Issue | 6 |
| Pages | 456 |
| Publication date | 2013-10-14 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Journal identifiers | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Publisher | African Journals Online (AJOL) (PUBLISHER) |
| DOI | 10.4314/ajtcam.v10i6.10 |
| PMID | 24311868 |
| OpenAlex | W2028873476 |
| Language | EN |
The objective of this paper was to investigate the extraction process of tanshinone IIA and its mechanism of induction of gastric cancer SGC7901 cell apoptosis. Extraction process of tanshinone IIA was optimised by orthogonal experimental method, and its effect on gastric cancer SGC7901 cell apoptosis was observed using MTT assay and electron microscopy. The optimum extraction process of tanshinone IIA was as follows: addition of a 10-fold amount of 80% ethanol, one-time extraction, and extraction time of 45 minutes. The study concluded that tanshinone IIA can induce apoptosis of gastric cancer SGC7901 cells
Apoptosis · Cancer · Cancer cell · Chromatography · MTT assay · Chemistry · Computer Science · Medicinal Plant Pharmacodynamics Research · Medicine · Metabolomics and Mass Spectrometry Studies · Traditional Chinese Medicine Analysis · Biochemistry · Internal Medicine
| Citation velocity | historical |
|---|---|
| Highly cited | No |