Brief communication
Oxygen isotopes as a biomarker for sickle‐cell disease? Results from transgenic mice expressing human hemoglobin S genes
Bibliographic Data
| ID | 8317300 |
|---|---|
| Authors | L J Reitsema (0000-0003-1127-3496, The Ohio State University, corresponding author), Douglas E Crews (0000-0002-3321-5898, The Ohio State University) |
| Year | 2011 |
| Volume | 145 |
| Issue | 3 |
| Pages | 495-498 |
| Publication date | 2011-07-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Physical Anthropology (JOURNAL) |
| Journal identifiers | ISSN: 0002-9483 • E-ISSN: 1096-8644 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajpa.21513 |
| PMID | 21541922 |
| OpenAlex | W2072367595 |
| Language | EN |
| Citations received | 10 |
| References cited | 25 |
The origins of sickle‐cell disease (SCD) are well understood, as are its evolutionary pressures on humans and pathological presentation. However, because it has not been possible to identify SCD in archaeological contexts, its biocultural effects on past populations are unknown. Previous research investigating oxygen isotope fractionation during respiration among anemics suggests that oxygen isotopes in bone apatite may provide a biological marker for SCD in skeletal remains. This pilot study reports δ 18 O ratios in bone apatite of transgenic laboratory mice expressing human SCD globins and compares them to healthy control mice. The δ 18 O ratios of sick mice are significantly lower than those of healthy mice (−5.6‰ vs. −4.5‰; P = 0.002), and the sickest mice exhibit the lowest ratios of all (mean δ 18 O = −5.8‰). These preliminary results suggest that this method may be usefully applied to skeletal materials of past human populations whose diets and water sources do not differ substantially. Am J Phys Anthropol, 2011. © 2011 Wiley‐Liss, Inc
Biology · Biomarker · Cell · Disease · Gene · Genetically modified mouse · Hemoglobin · Pathology · Sickle cell anemia · Transgene · Biochemistry · Forensic and Genetic Research · Forensic Anthropology and Bioarchaeology Studies · Genetics · Hemoglobinopathies and Related Disorders · Medicine · Physiology
Isotopic composition and identification of the origins of individuals buried in a Neolithic collective grave at Bronocice (southern Poland)
A Multi‐Isotopic Approach to Examining Mobility and Social Reorganization During the Bronze Age Transition in Ras Al Khaimah, UAE
On the Use of Biomineral Oxygen Isotope Data to Identify Human Migrants in the Archaeological Record
Beyond diet reconstruction
Beyond diet reconstruction
Laboratory and field methods for stable isotope analysis in human biology
Advances in primate stable isotope ecology—Achievements and future prospects
Oxygen isotope analysis of human bone phosphate evidences weaning age in archaeological populations
Geographic origins and dietary transitions during the bronze age in the oman peninsula
Residential patterns of Mexica human sacrifices at Mexico-Tenochtitlan and Mexico-Tlatelolco
Predicting animal δ18O
Fractionation of oxygen isotopes between mammalian bone-phosphate and environmental drinking water
A model of oxygen isotope fractionation in body water of large mammals
Turnover of oxygen and hydrogen isotopes in the body water, CO2, hair, and enamel of a small mammal
Recognition of sickle cell anemia in skeletal remains of children
Preparation of bone carbonate for stable isotope analysis
Immunological evidence of Plasmodium falciparum infection in an Egyptian child mummy from the Early Dynastic Period
The causes of porotic hyperostosis and cribra orbitalia
| Unique citing works | 10 |
|---|---|
| Citations per year | 0,77 |
| Citation span | 2013 - 2026 (14) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 8 |