A Health Status Questionnaire Using 30 Items From The Medical Outcomes Study

Preliminary Validation in Persons With Early HIV Infection

Bibliographic Data

ID9097646
AuthorsAlbert W Wu (0000-0001-6189-7120, University of California, San Francisco, corresponding author), Haya R Rubin (University of California, San Francisco), William C Mathews (0000-0002-2352-0725, University of California San Diego), John E Ware (0000-0002-0744-2149, Tufts Medical Center), Lucy T Brysk (University of California San Diego), William D Hardy (0000-0001-8948-9524, University of California, Los Angeles), Samuel A Bozzette (University of California San Diego), Stephen A Spector (0000-0002-1882-4855, University of California San Diego), Douglas D Richman (0000-0003-0962-9254, University of California, San Francisco, corresponding author)
Year1991
Volume29
Issue8
Pages786-798
Publication date1991-08-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueMedical Care (JOURNAL)
Journal identifiersISSN: 0025-7079 • E-ISSN: 1537-1948
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/00005650-199108000-00011
PMID1875745
OpenAlexW2085146082
LanguageEN
Citations received151

Many current health status instruments either are too long to use in many acquired immune deficiency syndrome (AIDS) clinical trials or omit important concepts. In this study, human immunodeficiency virus (HIV)-relevant items developed for the Medical Outcomes Study (MOS) from subscales for cognitive function, energy/fatigue, health distress, and a single quality of life item were added to a portion of the MOS Short-form General Health Survey. The resulting 30-item questionnaire reliably and distinctly measured ten aspects of health and took less than 5 minutes to complete. To test its validity, this modified measure was used to compare the health of 73 subjects with asymptomatic HIV infection and 44 with early AIDS-related complex (ARC). Compared with ARC subjects, asymptomatic individuals reported superior overall health, less pain, and better physical function, role function, cognitive function, and quality of life (rank-sum, P less than 0.02). Asymptomatic subjects' scores were higher on most subscales than the age-adjusted scores of MOS outpatients with hypertension, diabetes, recent myocardial infarction, or depression; ARC patients scored closest to hypertensive patients. This instrument, containing a subset of the MOS measures of health-related quality of life, may be a useful outcome measure for AIDS clinical trials

Asymptomatic · Cognition · Depression (economics) · Distress · Physical therapy · Psychiatry · Quality of life (healthcare) · Clinical Psychology · HIV-related health complications and treatments · HIV/AIDS Research and Interventions · Internal Medicine · Medicine