Johannes G Ramaekers
Datos Biográficos
| ID | 1754504 |
|---|---|
| NOMBRE | Johannes G Ramaekers |
| NOMBRES | Johannes G |
| APELLIDO | Ramaekers |
| FIRMA | RAMAEKERS J G |
| AFILIACIONES | Maastricht University |
| ORCID | 0000-0003-4553-376X |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 16 |
| TOTAL DE CITAS | 1 |
| TOTAL COMO AUTOR | 16 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 2016 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2026 |
| ÍNDICE H | 1 |
Pivotal physical states
Exploring the importance of bodyset for the psychedelic experience and beyond
BackgroundResearch has shown that psychedelics may have therapeutic potential in treating mental disorders like depression and anxiety. However, the mechanisms and actions underlying their effects are still not fully understood. Similarly, while the significance of mindset and setting in shaping psychedelic experiences and therapeutic outcomes is well established, information about the influence of the body is comparatively scarce.AimThis paper i…
A phase 1/2 trial to assess safety and efficacy of a vaporized 5-methoxy-N,N-dimethyltryptamine formulation (GH001) in patients with treatment-resistant depression
Administration of GH001 to a cohort of 16 patients with TRD was well tolerated and provided potent and ultra-rapid antidepressant effects. Individualized dosing with up to three doses of GH001 on a single day was superior to single dose administration. Clinical Trial registration : Clinicaltrials.gov Identifier NCT04698603
Methylphenidate as a treatment option for substance use disorder
A transition in viewing mental disorders from conditions defined as a set of unique characteristics to one of the quantitative variations on a collection of dimensions allows overlap between disorders. The overlap can be utilized to extend to treatment approaches. Here, we consider the overlap between attention-deficit/hyperactivity disorder and substance use disorder to probe the suitability to use methylphenidate as a treatment for substance us…
A Preliminary Inventory of Kratom (Mitragyna Speciosa) Products and Vendors on the Darknet and Cryptomarkets
In recent years, the online sale of kratom ( Mitragyna speciosa ), a Southeast Asian plant with both medicinal and psychoactive properties, has raised health concerns mainly due to the uncontrolled diffusion of adulterated kratom-related products. This exploratory study provides, for the first time, a snapshot of the availability of kratom products on the darknet which has been further validated by data searches on the surface web. A total of 231…
Cannabis Use and Neuroadaptation
Currently, the assessment of the neurobehavioral consequences of repeated cannabis use is restricted to studies in which brain function of chronic cannabis users is compared to that of non-cannabis using controls. The assumption of such studies is that changes in brain function of chronic users are caused by repeated and prolonged exposure to acute cannabis intoxication. However, differences in brain function between chronic cannabis users and no…
Decreases in State and Trait Anxiety Post-psilocybin
Anxiety disorders are the most common type of psychiatric disorders among Western countries. Evidence-based treatment modalities including pharmacological and cognitive-behavioral therapy result in deficient treatment responses. Historical and recent research suggests psychedelic drugs may be efficacious in alleviating anxiety-related symptoms among healthy and clinical populations. The main aim of the present study was investigation of the effec…
A Comparison of Acute Neurocognitive and Psychotomimetic Effects of a Synthetic Cannabinoid and Natural Cannabis at Psychotropic Dose Equivalence
Due to differences in potency, efficacy, and affinity for CB1 receptors, similarities and differences in psychoactive effect profiles of natural cannabis and synthetic cannabinoids (SCs) cannot reliably be derived from equipotent dose comparisons. Instead, the current study proposes to compare the intrinsic psychoactive effects of natural cannabis (THC) and an SC, JWH-018, at psychotropic dose equivalence. Participants from two placebo-controlled…
Altered States of Consciousness During Ceremonial San Pedro Use
San Pedro, a mescaline containing cactus, has been used for thousands of years and is currently popular as a psychedelic substance in ceremonial retreats in Europe. The current research investigates the consciousness altering effects of San Pedro. Forty-two participants who joined ceremonial psychedelic retreats in the Netherlands were investigated with questionnaires probing 11 dimensions of altered states of consciousness (11D-ASC), ego-dissolu…
An experience with Holotropic Breathwork is associated with improvement in non-judgement and satisfaction with life while reducing symptoms of stress in a Czech-speaking population
BackgroundHolotropic breathwork (Grof (R) Breathwork), was developed by Stanislav Grof and Christina Grof as a 'non-drug' alternative technique to evoke altered states of consciousness (ASC). Interestingly, although HBW has been anecdotally reported to evoke experiences and mental health effects corresponding to those of psychedelic substances, the scientific literature on the matter is scarce.AimsThe objective of this study was to assess the (su…
Use characteristics and harm potential of ecstasy in The Netherlands
Introduction Ecstasy (MDMA) is a popular recreational drug, but its illegal production and trade in the Netherlands have developed into a serious public order and ecological problem which endanger and question the harm reduction approach of the Dutch ecstasy policy.Methods The market characteristics, adverse health effects, risk profile, and link to criminal activity of ecstasy were reviewed.Results Ecstasy is often used in combination with other…
Sub-acute and long-term effects of ayahuasca on mental health and well-being in healthy ceremony attendants
Background and aims There is a growing body of evidence suggesting that the psychedelic plant tea, ayahuasca, holds therapeutic potential. Uthaug et al. (2018) demonstrated that a single dose of ayahuasca improved mental health sub-acutely and 4-weeks post-ceremony in healthy participants. The present study aimed to replicate and extend these findings. A first objective was to assess the sub-acute and long-term effects of ayahuasca on mental heal…
Cannabis Crashes
A comparison of reactivation experiences following vaporization and intramuscular injection (IM) of synthetic 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting
BackgroundPrevious research suggests a therapeutic potential of5-methoxy-N,N-dimethyltryptamine(5-MeO-DMT). However, online anecdotal reports have described a phenomenon following cessation of the acute effects of 5-MeO-DMT use which has been termedreactivation(i.e., re-experiencing ["flashback"]). To date, no research has investigated whether different routes of administration may confer different reactivation rates, effects and experiences.Aims…
A First-in-Man Study with 4-Fluoroamphetamine Demonstrates it Produces a Mild Psychedelic State
The phenethylamine 4-fluoroamphetamine (4-FA) is a so-called novel psychoactive substance with a chemical structure resembling that of amphetamine and MDMA. Since 4-FA users report their subjective experience ranges between the effects induced by amphetamine and MDMA, and it is known that both substances can produce an altered state of consciousness, this study tests whether 4-FA induces a psychedelic state. A placebo-controlled two-way crossover…
Infusing pleasure
Infusing pleasure
A First-in-Man Study with 4-Fluoroamphetamine Demonstrates it Produces a Mild Psychedelic State
The phenethylamine 4-fluoroamphetamine (4-FA) is a so-called novel psychoactive substance with a chemical structure resembling that of amphetamine and MDMA. Since 4-FA users report their subjective experience ranges between the effects induced by amphetamine and MDMA, and it is known that both substances can produce an altered state of consciousness, this study tests whether 4-FA induces a psychedelic state. A placebo-controlled two-way crossover…
Cannabis Crashes
A comparison of reactivation experiences following vaporization and intramuscular injection (IM) of synthetic 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting
BackgroundPrevious research suggests a therapeutic potential of5-methoxy-N,N-dimethyltryptamine(5-MeO-DMT). However, online anecdotal reports have described a phenomenon following cessation of the acute effects of 5-MeO-DMT use which has been termedreactivation(i.e., re-experiencing ["flashback"]). To date, no research has investigated whether different routes of administration may confer different reactivation rates, effects and experiences.Aims…
Use characteristics and harm potential of ecstasy in The Netherlands
Introduction Ecstasy (MDMA) is a popular recreational drug, but its illegal production and trade in the Netherlands have developed into a serious public order and ecological problem which endanger and question the harm reduction approach of the Dutch ecstasy policy.Methods The market characteristics, adverse health effects, risk profile, and link to criminal activity of ecstasy were reviewed.Results Ecstasy is often used in combination with other…
Sub-acute and long-term effects of ayahuasca on mental health and well-being in healthy ceremony attendants
Background and aims There is a growing body of evidence suggesting that the psychedelic plant tea, ayahuasca, holds therapeutic potential. Uthaug et al. (2018) demonstrated that a single dose of ayahuasca improved mental health sub-acutely and 4-weeks post-ceremony in healthy participants. The present study aimed to replicate and extend these findings. A first objective was to assess the sub-acute and long-term effects of ayahuasca on mental heal…
Cannabis Use and Neuroadaptation
Currently, the assessment of the neurobehavioral consequences of repeated cannabis use is restricted to studies in which brain function of chronic cannabis users is compared to that of non-cannabis using controls. The assumption of such studies is that changes in brain function of chronic users are caused by repeated and prolonged exposure to acute cannabis intoxication. However, differences in brain function between chronic cannabis users and no…
Decreases in State and Trait Anxiety Post-psilocybin
Anxiety disorders are the most common type of psychiatric disorders among Western countries. Evidence-based treatment modalities including pharmacological and cognitive-behavioral therapy result in deficient treatment responses. Historical and recent research suggests psychedelic drugs may be efficacious in alleviating anxiety-related symptoms among healthy and clinical populations. The main aim of the present study was investigation of the effec…
A Comparison of Acute Neurocognitive and Psychotomimetic Effects of a Synthetic Cannabinoid and Natural Cannabis at Psychotropic Dose Equivalence
Due to differences in potency, efficacy, and affinity for CB1 receptors, similarities and differences in psychoactive effect profiles of natural cannabis and synthetic cannabinoids (SCs) cannot reliably be derived from equipotent dose comparisons. Instead, the current study proposes to compare the intrinsic psychoactive effects of natural cannabis (THC) and an SC, JWH-018, at psychotropic dose equivalence. Participants from two placebo-controlled…
Altered States of Consciousness During Ceremonial San Pedro Use
San Pedro, a mescaline containing cactus, has been used for thousands of years and is currently popular as a psychedelic substance in ceremonial retreats in Europe. The current research investigates the consciousness altering effects of San Pedro. Forty-two participants who joined ceremonial psychedelic retreats in the Netherlands were investigated with questionnaires probing 11 dimensions of altered states of consciousness (11D-ASC), ego-dissolu…
An experience with Holotropic Breathwork is associated with improvement in non-judgement and satisfaction with life while reducing symptoms of stress in a Czech-speaking population
BackgroundHolotropic breathwork (Grof (R) Breathwork), was developed by Stanislav Grof and Christina Grof as a 'non-drug' alternative technique to evoke altered states of consciousness (ASC). Interestingly, although HBW has been anecdotally reported to evoke experiences and mental health effects corresponding to those of psychedelic substances, the scientific literature on the matter is scarce.AimsThe objective of this study was to assess the (su…
A phase 1/2 trial to assess safety and efficacy of a vaporized 5-methoxy-N,N-dimethyltryptamine formulation (GH001) in patients with treatment-resistant depression
Administration of GH001 to a cohort of 16 patients with TRD was well tolerated and provided potent and ultra-rapid antidepressant effects. Individualized dosing with up to three doses of GH001 on a single day was superior to single dose administration. Clinical Trial registration : Clinicaltrials.gov Identifier NCT04698603
Methylphenidate as a treatment option for substance use disorder
A transition in viewing mental disorders from conditions defined as a set of unique characteristics to one of the quantitative variations on a collection of dimensions allows overlap between disorders. The overlap can be utilized to extend to treatment approaches. Here, we consider the overlap between attention-deficit/hyperactivity disorder and substance use disorder to probe the suitability to use methylphenidate as a treatment for substance us…
A Preliminary Inventory of Kratom (Mitragyna Speciosa) Products and Vendors on the Darknet and Cryptomarkets
In recent years, the online sale of kratom ( Mitragyna speciosa ), a Southeast Asian plant with both medicinal and psychoactive properties, has raised health concerns mainly due to the uncontrolled diffusion of adulterated kratom-related products. This exploratory study provides, for the first time, a snapshot of the availability of kratom products on the darknet which has been further validated by data searches on the surface web. A total of 231…
Exploring the importance of bodyset for the psychedelic experience and beyond
BackgroundResearch has shown that psychedelics may have therapeutic potential in treating mental disorders like depression and anxiety. However, the mechanisms and actions underlying their effects are still not fully understood. Similarly, while the significance of mindset and setting in shaping psychedelic experiences and therapeutic outcomes is well established, information about the influence of the body is comparatively scarce.AimThis paper i…
Pivotal physical states
Psychology (13 obras) · Medicine (10 obras) · Psychedelics and Drug Studies (10 obras) · Psychiatry (10 obras) · Cognition (5 obras) · Neurotransmitter Receptor Influence on Behavior (5 obras) · Cannabis and Cannabinoid Research (4 obras) · Clinical Psychology (4 obras) · Forensic Toxicology and Drug Analysis (4 obras) · Hallucinogen (4 obras)