A comparison of reactivation experiences following vaporization and intramuscular injection (IM) of synthetic 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting

Datos Bibliográficos

ID4615368
AutoresM V Uthaug (0000-0001-7903-1325, Maastricht University, autor de correspondencia), R Lancelotta (InnatePath,Lakewood), Rafaelle L Lancelotta (0000-0002-7789-3463), Ana María Ortiz Bernal (0000-0003-3304-6497, University of Wisconsin–Madison), A K Davis (0000-0003-4770-8893, Johns Hopkins University), Johannes G Ramaekers (0000-0003-4553-376X, Maastricht University)
Año2020
Volumen4
Número2
Páginas104-113
Fecha de publicación2020-06-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaJournal of Psychedelic Studies (JOURNAL)
Identificadores de la revistaISSN: 2559-9283 • E-ISSN: 2559-9283
EditorialAkademiai Kiado Zrt (PUBLISHER)
DOI10.1556/2054.2020.00123
OpenAlexW3013834281
IdiomaEN
Citas recibidas6
Referencias citadas43

BackgroundPrevious research suggests a therapeutic potential of5-methoxy-N,N-dimethyltryptamine(5-MeO-DMT). However, online anecdotal reports have described a phenomenon following cessation of the acute effects of 5-MeO-DMT use which has been termedreactivation(i.e., re-experiencing ["flashback"]). To date, no research has investigated whether different routes of administration may confer different reactivation rates, effects and experiences.AimsWe aimed to assess whether intramuscular injection (IM) and vaporization of 5-MeO-DMT conferred different reactivation rates, changes in satisfaction with life as well as ratings of the experience with ego dissolution and the mystical.MethodsUsing internet-based advertisements, 27 respondents (Mage= 32. SE = 1.43; males = 18; North America = 19) completed an online-based survey.ResultsOf the 14 participants in the IM group, 3 (21%) reported reactivations; in contrast, of the 13 participants in the vaporization group, 9 (69%) reported reactivations. Redosing (more than 1 dose) occurred more frequently in the vaporization group (N= 8) (1-6 times with 3-35 mg of 5-MeO-DMT), relative to the IM group (N= 2) (1-5 times with 5-10 mg of 5-MeO-DMT). All participants in the IM group experienced release of physical tension, compared to 8 participants in the vaporization group. Participants in the IM group reported longer time of onset of acute effects (between 1 and 3 [N= 6] and 4-6 min [N= 6]), relative to the vaporization group where the majority (N= 11) reported a rapid onset of 1-50 s.ConclusionFindings suggest that compared to vaporization, the IM route of administering 5-MeO-DMT is associated with lower and less doses, lower frequencies of reporting reactivation, a higher frequency of physical tension release, and a slower onset of acute effects

Anesthesia · Hallucinogen · Psychiatry · Vaporization · Body Image and Dysmorphia Studies · Chemistry · Complementary and Alternative Medicine Studies · Medicine · Psychedelics and Drug Studies · Psychology