Barbara Bramanti
Datos Biográficos
| ID | 84459 |
|---|---|
| NOMBRE | Barbara Bramanti |
| NOMBRES | Barbara |
| APELLIDO | Bramanti |
| FIRMA | BRAMANTI B |
| AFILIACIONES | University of Ferrara |
| ORCID | 0000-0002-5433-663X |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 14 |
| TOTAL DE CITAS | 42 |
| TOTAL COMO AUTOR | 14 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 2000 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2026 |
| ÍNDICE H | 4 |
Next‐Generation Paleopathology
Artificial intelligence encompasses computational systems capable of performing cognitive functions such as learning, reasoning, and problem‐solving. Within this domain, generative AI and large language models such as ChatGPT, Gemini, and Copilot have shown significant potential in clinical diagnostics. Their capacity to generate structured differential diagnoses, integrate radiological criteria, and synthesize complex information underscores the…
Sex Differences in Body Image Perception and Ideals
The study analyzed the differences between sexes in body image perception and body ideals to assess possible dissatisfaction and misinterpretation in the body image considered attractive for the other sex. Moreover, the influence of anthropometric traits and sports practice on body dissatisfaction and misjudgment was evaluated. Using a cross-sectional design, 960 Italian university students were investigated. Anthropometric characteristics were m…
Overall frailty gauged in victims of the Italian plague (Imola, 1630-1632)
Plague is an epidemic-prone infectious disease that has affected humanity with catastrophic effects throughout almost its entire history. One of the most intriguing questions of the last years is whether plague kills indiscriminately. To address the question regarding pre-existent health conditions, this study aims to assess the overall frailty of plague victims and compare it with a sample of non-plague victims from the same period and area. Fra…
The biological index of frailty
OBJECTIVE: Frailty is the physiological stress that individuals suffer during their life. In past populations, frailty is conventionally assessed through the occurrence of different biomarkers of biological stress. Some efforts have been made to propose indexes that combine all biomarkers. However, these indices have some critical limitations: they cannot be used on incomplete skeletons, do not consider the severity and/or healing of lesions, and…
A new investigative strategy to diagnose β-thalassemia syndrome in past human populations
The study of thalassaemia syndromes in archeological human remains is of growing interest in the field of paleopathology. However, a definitive diagnosis of the disease in skeletonized individuals remains difficult. Several non-specific bone lesions have been suggested as the most likely evidence of β-thalassaemia syndrome. In particular, skull lesions have been considered by several scholars as the most indicative of this hematopoietic disorder,…
Handgrip Strength in Young Adults
The measurement of handgrip strength (HGS) is an indicator of an individual's overall strength and can serve as a predictor of morbidity and mortality. This study aims to investigate whether HGS is associated with handedness in young adults and if it is influenced by anthropometric characteristics, body composition, and sport-related parameters. We conducted a cross-sectional study on a sample of 544 young Italian adults aged 18-30 years. We meas…
How reliable is the assessment of Porotic Hyperostosis and Cribra Orbitalia in skeletal human remains? A methodological approach for quantitative verification by means of a new evaluation form
Intra vitam porous lesions of the skull (Cribra Orbitalia and Porotic Hyperostosis) are pathological conditions due to genetic or acquired chronic anaemia. They are the most reported skeletal lesions in human skeletal remains and are routinely used to assess health, hygiene and nutritional status of past populations. Despite the existence of a number of proposed classifications, there is no generally accepted classification system used by all, wi…
Genetic Discontinuity Between Local Hunter-Gatherers and Central Europe’s First Farmers
Cultivating Farmers Were the ancestors of modern Europeans the local hunter-gatherers who assimilated farming practices from neighboring cultures, or were they farmers who migrated from the Near East in the early Neolithic? By analyzing ancient hunter-gatherer skeletal DNA from 2300 to 13,400 B.C.E. Bramanti et al. (p. 137 , published online 3 September) investigated the genetic relationship of European Ice Age hunter-gatherers, the first farmers…
Ancient DNA from the First European Farmers in 7500-Year-Old Neolithic Sites
The ancestry of modern Europeans is a subject of debate among geneticists, archaeologists, and anthropologists. A crucial question is the extent to which Europeans are descended from the first European farmers in the Neolithic Age 7500 years ago or from Paleolithic hunter-gatherers who were present in Europe since 40,000 years ago. Here we present an analysis of ancient DNA from early European farmers. We successfully extracted and sequenced inta…
Ancient DNA Analysis of the Delta F508 Mutation
When working with highly degraded DNA, validating the results of a slightly polymorphic system always complicates the analysis because of the difficulties in recognizing contamination and artifacts. Recognition can be greatly simplified by employing a multiplex reaction that coamplifies the fragments together with several highly polymorphic markers, for instance, short tandem repeats. In this work, we successfully included newly designed oligonuc…
The selective advantage of cystic fibrosis heterozygotes tested by aDNA analysis
Recently a heterozygote advantage was suggested to explain the high incidence (1:25 carrier individuals in Europeans) of the cystic fibrosis gene. This selective advantage was speculated to be due to a high resistance to chloride-secreting diarrhea, including cholera. Up to now the major efforts to test directly this hypothesis have been limited to animal models. We propose to verify the hypothesis directly on a sample of human individuals who di…
STR Allelic Frequencies in a German Skeleton Collection
Chromosomal DNA was isolated from bones from a German skeleton collection (Goslar, 18th century) and detected by PCR. Nine microsatellite regions were amplified by multiplex reactions using the AmpFlSTR Profiler Plus kit and analysed to obtain their allelic distribution. A statistical evaluation of the results revealed no allelic differentiation between the historic sample and a modern German one at each locus.
Megaplex DNA typing can provide a strong indication of the authenticity of ancient DNA amplifications by clearly recognizing any possible type of modern contamination
Recent experiments revealed the perfect applicability of megaplex typing by autosomal short tandem repeats (STRs) to degraded DNA. The advantages of megaplex approaches lie in reduced amounts of sample material that are necessary and in remarkable time saving. Furthermore, megaplex typing clearly recognizes possible contaminations and thus has a large potential for indicating authenticity in ancient DNA analysis. This is demonstrated by three exa…
Evaluation of morphological sex determinations by molecular analyses
The study presents an evaluation of morphological sex determinations of adult skeletal individuals based on traits of the ossa coxae and the cranium. The evaluation criterion was genetic analysis of the amelogenine gene, which represents parts of the X- and the Y-chromosome (Mannucci et al. 1994). The study was carried out on 33 human skeletons from an early modern burial site in Lower Saxony. In this skeletal series, 88% of the morphological sex…
How reliable is the assessment of Porotic Hyperostosis and Cribra Orbitalia in skeletal human remains? A methodological approach for quantitative verification by means of a new evaluation form
Intra vitam porous lesions of the skull (Cribra Orbitalia and Porotic Hyperostosis) are pathological conditions due to genetic or acquired chronic anaemia. They are the most reported skeletal lesions in human skeletal remains and are routinely used to assess health, hygiene and nutritional status of past populations. Despite the existence of a number of proposed classifications, there is no generally accepted classification system used by all, wi…
The biological index of frailty
OBJECTIVE: Frailty is the physiological stress that individuals suffer during their life. In past populations, frailty is conventionally assessed through the occurrence of different biomarkers of biological stress. Some efforts have been made to propose indexes that combine all biomarkers. However, these indices have some critical limitations: they cannot be used on incomplete skeletons, do not consider the severity and/or healing of lesions, and…
A new investigative strategy to diagnose β-thalassemia syndrome in past human populations
The study of thalassaemia syndromes in archeological human remains is of growing interest in the field of paleopathology. However, a definitive diagnosis of the disease in skeletonized individuals remains difficult. Several non-specific bone lesions have been suggested as the most likely evidence of β-thalassaemia syndrome. In particular, skull lesions have been considered by several scholars as the most indicative of this hematopoietic disorder,…
Overall frailty gauged in victims of the Italian plague (Imola, 1630-1632)
Plague is an epidemic-prone infectious disease that has affected humanity with catastrophic effects throughout almost its entire history. One of the most intriguing questions of the last years is whether plague kills indiscriminately. To address the question regarding pre-existent health conditions, this study aims to assess the overall frailty of plague victims and compare it with a sample of non-plague victims from the same period and area. Fra…
Megaplex DNA typing can provide a strong indication of the authenticity of ancient DNA amplifications by clearly recognizing any possible type of modern contamination
Recent experiments revealed the perfect applicability of megaplex typing by autosomal short tandem repeats (STRs) to degraded DNA. The advantages of megaplex approaches lie in reduced amounts of sample material that are necessary and in remarkable time saving. Furthermore, megaplex typing clearly recognizes possible contaminations and thus has a large potential for indicating authenticity in ancient DNA analysis. This is demonstrated by three exa…
Ancient DNA Analysis of the Delta F508 Mutation
When working with highly degraded DNA, validating the results of a slightly polymorphic system always complicates the analysis because of the difficulties in recognizing contamination and artifacts. Recognition can be greatly simplified by employing a multiplex reaction that coamplifies the fragments together with several highly polymorphic markers, for instance, short tandem repeats. In this work, we successfully included newly designed oligonuc…
STR Allelic Frequencies in a German Skeleton Collection
Chromosomal DNA was isolated from bones from a German skeleton collection (Goslar, 18th century) and detected by PCR. Nine microsatellite regions were amplified by multiplex reactions using the AmpFlSTR Profiler Plus kit and analysed to obtain their allelic distribution. A statistical evaluation of the results revealed no allelic differentiation between the historic sample and a modern German one at each locus.
Evaluation of morphological sex determinations by molecular analyses
The study presents an evaluation of morphological sex determinations of adult skeletal individuals based on traits of the ossa coxae and the cranium. The evaluation criterion was genetic analysis of the amelogenine gene, which represents parts of the X- and the Y-chromosome (Mannucci et al. 1994). The study was carried out on 33 human skeletons from an early modern burial site in Lower Saxony. In this skeletal series, 88% of the morphological sex…
The selective advantage of cystic fibrosis heterozygotes tested by aDNA analysis
Recently a heterozygote advantage was suggested to explain the high incidence (1:25 carrier individuals in Europeans) of the cystic fibrosis gene. This selective advantage was speculated to be due to a high resistance to chloride-secreting diarrhea, including cholera. Up to now the major efforts to test directly this hypothesis have been limited to animal models. We propose to verify the hypothesis directly on a sample of human individuals who di…
STR Allelic Frequencies in a German Skeleton Collection
Chromosomal DNA was isolated from bones from a German skeleton collection (Goslar, 18th century) and detected by PCR. Nine microsatellite regions were amplified by multiplex reactions using the AmpFlSTR Profiler Plus kit and analysed to obtain their allelic distribution. A statistical evaluation of the results revealed no allelic differentiation between the historic sample and a modern German one at each locus.
Megaplex DNA typing can provide a strong indication of the authenticity of ancient DNA amplifications by clearly recognizing any possible type of modern contamination
Recent experiments revealed the perfect applicability of megaplex typing by autosomal short tandem repeats (STRs) to degraded DNA. The advantages of megaplex approaches lie in reduced amounts of sample material that are necessary and in remarkable time saving. Furthermore, megaplex typing clearly recognizes possible contaminations and thus has a large potential for indicating authenticity in ancient DNA analysis. This is demonstrated by three exa…
Evaluation of morphological sex determinations by molecular analyses
The study presents an evaluation of morphological sex determinations of adult skeletal individuals based on traits of the ossa coxae and the cranium. The evaluation criterion was genetic analysis of the amelogenine gene, which represents parts of the X- and the Y-chromosome (Mannucci et al. 1994). The study was carried out on 33 human skeletons from an early modern burial site in Lower Saxony. In this skeletal series, 88% of the morphological sex…
Ancient DNA Analysis of the Delta F508 Mutation
When working with highly degraded DNA, validating the results of a slightly polymorphic system always complicates the analysis because of the difficulties in recognizing contamination and artifacts. Recognition can be greatly simplified by employing a multiplex reaction that coamplifies the fragments together with several highly polymorphic markers, for instance, short tandem repeats. In this work, we successfully included newly designed oligonuc…
Ancient DNA from the First European Farmers in 7500-Year-Old Neolithic Sites
The ancestry of modern Europeans is a subject of debate among geneticists, archaeologists, and anthropologists. A crucial question is the extent to which Europeans are descended from the first European farmers in the Neolithic Age 7500 years ago or from Paleolithic hunter-gatherers who were present in Europe since 40,000 years ago. Here we present an analysis of ancient DNA from early European farmers. We successfully extracted and sequenced inta…
Genetic Discontinuity Between Local Hunter-Gatherers and Central Europe’s First Farmers
Cultivating Farmers Were the ancestors of modern Europeans the local hunter-gatherers who assimilated farming practices from neighboring cultures, or were they farmers who migrated from the Near East in the early Neolithic? By analyzing ancient hunter-gatherer skeletal DNA from 2300 to 13,400 B.C.E. Bramanti et al. (p. 137 , published online 3 September) investigated the genetic relationship of European Ice Age hunter-gatherers, the first farmers…
How reliable is the assessment of Porotic Hyperostosis and Cribra Orbitalia in skeletal human remains? A methodological approach for quantitative verification by means of a new evaluation form
Intra vitam porous lesions of the skull (Cribra Orbitalia and Porotic Hyperostosis) are pathological conditions due to genetic or acquired chronic anaemia. They are the most reported skeletal lesions in human skeletal remains and are routinely used to assess health, hygiene and nutritional status of past populations. Despite the existence of a number of proposed classifications, there is no generally accepted classification system used by all, wi…
Handgrip Strength in Young Adults
The measurement of handgrip strength (HGS) is an indicator of an individual's overall strength and can serve as a predictor of morbidity and mortality. This study aims to investigate whether HGS is associated with handedness in young adults and if it is influenced by anthropometric characteristics, body composition, and sport-related parameters. We conducted a cross-sectional study on a sample of 544 young Italian adults aged 18-30 years. We meas…
The biological index of frailty
OBJECTIVE: Frailty is the physiological stress that individuals suffer during their life. In past populations, frailty is conventionally assessed through the occurrence of different biomarkers of biological stress. Some efforts have been made to propose indexes that combine all biomarkers. However, these indices have some critical limitations: they cannot be used on incomplete skeletons, do not consider the severity and/or healing of lesions, and…
A new investigative strategy to diagnose β-thalassemia syndrome in past human populations
The study of thalassaemia syndromes in archeological human remains is of growing interest in the field of paleopathology. However, a definitive diagnosis of the disease in skeletonized individuals remains difficult. Several non-specific bone lesions have been suggested as the most likely evidence of β-thalassaemia syndrome. In particular, skull lesions have been considered by several scholars as the most indicative of this hematopoietic disorder,…
Sex Differences in Body Image Perception and Ideals
The study analyzed the differences between sexes in body image perception and body ideals to assess possible dissatisfaction and misinterpretation in the body image considered attractive for the other sex. Moreover, the influence of anthropometric traits and sports practice on body dissatisfaction and misjudgment was evaluated. Using a cross-sectional design, 960 Italian university students were investigated. Anthropometric characteristics were m…
Overall frailty gauged in victims of the Italian plague (Imola, 1630-1632)
Plague is an epidemic-prone infectious disease that has affected humanity with catastrophic effects throughout almost its entire history. One of the most intriguing questions of the last years is whether plague kills indiscriminately. To address the question regarding pre-existent health conditions, this study aims to assess the overall frailty of plague victims and compare it with a sample of non-plague victims from the same period and area. Fra…
Next‐Generation Paleopathology
Artificial intelligence encompasses computational systems capable of performing cognitive functions such as learning, reasoning, and problem‐solving. Within this domain, generative AI and large language models such as ChatGPT, Gemini, and Copilot have shown significant potential in clinical diagnostics. Their capacity to generate structured differential diagnoses, integrate radiological criteria, and synthesize complex information underscores the…
Biology (10 obras) · Medicine (7 obras) · Forensic and Genetic Research (6 obras) · Forensic Anthropology and Bioarchaeology Studies (6 obras) · Gene (6 obras) · Genetics (5 obras) · Ancient DNA (4 obras) · Archaeology (4 obras) · Demography (4 obras) · Geography (4 obras)