The selective advantage of cystic fibrosis heterozygotes tested by aDNA analysis

A preliminary investigation

Datos Bibliográficos

ID12029992
AutoresBarbara Bramanti (0000-0002-5433-663X, University of Göttingen, autor de correspondencia), Luca Sìneo (0000-0001-8634-2295, University of Palermo), Marika Vianello (0009-0006-0864-7230, University of Florence), D Caramelli (University of Florence), Hummel (0000-0002-3647-8968, University of Göttingen), S Hummel, B Chiarelli (University of Florence), Bernd Herrmann (University of Göttingen)
Año2000
Volumen15
Número3-4
Páginas255-262
Fecha de publicación2000-07-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaInternational Journal of Anthropology (JOURNAL)
Identificadores de la revistaISSN: 0393-9383 • E-ISSN: 1824-3096
EditorialSpringer Nature (PUBLISHER • SG)
DOI10.1007/bf02445136
OpenAlexW1993346409
IdiomaEN
Citas recibidas4
Referencias citadas19

Recently a heterozygote advantage was suggested to explain the high incidence (1:25 carrier individuals in Europeans) of the cystic fibrosis gene. This selective advantage was speculated to be due to a high resistance to chloride-secreting diarrhea, including cholera. Up to now the major efforts to test directly this hypothesis have been limited to animal models. We propose to verify the hypothesis directly on a sample of human individuals who died from cholera during the epidemic in the Mediterranean basin at the beginning of the nineteenth century. In this preliminary investigation we have attempted to check for the presence of amplifiable DNA in the human remains simultaneously in terms of genetic fingerprints and for cystic fibrosis mutations

Allele · Biology · Cholera · Cystic fibrosis · Gene · Heterozygote advantage · Mutation · Biosensors and Analytical Detection · Cystic Fibrosis Research Advances · Vibrio bacteria research studies · Genetics · Virology