Hypothesis

European populations have both a particularly long history of pulmonary tuberculosis and extremely high frequencies of cystic fibrosis (CF). While carriers of the recessive gene are asymptomatic for CF disease, their fibroblasts produce excessive amounts of hyaluronic acid, whose role in successful isolation of virulent pathogens appears to be especially adaptive in host resistance to the human strain of Mycobacterium tuberculosis. CF heterozygosity may have been an adaptation to a disease environment once dominated by this infection

Allele · Asymptomatic · Biology · Compound heterozygosity · Cystic fibrosis · Disease · Gene · Heterozygote advantage · Loss of heterozygosity · Mycobacterium tuberculosis · Pathology · Phenotype · Tuberculosis · Virulence · Cystic Fibrosis Research Advances · Genetics · Immunology · Medicine · Microbiology · Mycobacterium research and diagnosis · Tuberculosis Research and Epidemiology

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  Open Access•Barbara Bramanti, Luca Sìneo et al.•International Journal of…•2000

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• Protection Afforded by Sickle-cell Trait Against Subtertian Malarial Infection

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• Indications of Change in Developing Country Mortality Trends

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