Serotonin, Septal Lesions, and Shock-Escape Learning in Rats

The involvement of reduced serotonin in deficient leverpress, shock-escape performance of rats with septal lesions was assessed in two studies. In Exp. 1, rats were treated with either para-chlorophenylalanine (PCPA) or saline and then tested in a leverpress, shock-escape task. In Exp. 2, rats with septal lesions and sham-operated control rats were treated daily with either 5-hydroxytryptophan (5HTP) or saline and tested on the same shock-escape task. Primary findings were as follows: (a) rats treated with PCPA learned to escape shock as quickly as saline control rats; (b) the shock-escape performance of rats with septal lesions was significantly inferior to that of control rats; and (c) the administration of 5HTP did not significantly improve the performance of either lesioned or control rats. These results suggest that the reduction of brain serotonin induced by septal lesions is not involved in the deficient shock-escape performance of septal-lesioned rats

Anesthesia · Escape response · Receptor · Saline · Serotonin · Shock (circulatory · Animal testing and alternatives · Endocrinology · Internal Medicine · Medicine · Neuroscience · Neurotransmitter Receptor Influence on Behavior · Psychology · Receptor Mechanisms and Signaling

• Septum and behavior

  P A FRIED, Fried Pa•Psychological Bulletin•1972

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• Varied Shock and Simple Escape

  Open Access•Francis H Osborne•Psychological Reports•1971

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