Saffron improves the efficacy of immunotherapy for colorectal cancer through the IL-17 signaling pathway

Datos Bibliográficos

ID14733191
AutoresSiqi Feng (0009-0003-5313-5806, Shanghai University of Traditional Chinese Medicine), Shiying Li (0000-0002-8184-4568, Seoul National University), Zhonghua Wu (0000-0001-6252-3331), Zhong-Hua Wu (Shanghai University of Traditional Chinese Medicine), Yun Li (0000-0001-8225-4554, Shanghai University of Traditional Chinese Medicine), Tingting Wu (0000-0001-8236-2256, Shanghai University of Traditional Chinese Medicine), Zhangjie Zhou (Shanghai University of Traditional Chinese Medicine), Xinhua Liu (0000-0002-7797-6699, Shanghai University of Traditional Chinese Medicine), Jian Chen (0000-0002-9033-4033, Shanghai University of Traditional Chinese Medicine), Shujuan Fu (Shanghai University of Traditional Chinese Medicine), Zhiying Wang (0000-0003-3339-3085, Shanghai University of Traditional Chinese Medicine), Zhixian Zhong (0000-0002-5408-7776, Tongji University), Yi Zhong (0000-0002-1411-2711, Shanghai University of Traditional Chinese Medicine, autor de correspondencia)
Año2025
Volumen337
NúmeroPt 2
Páginas118854
Fecha de publicación2025-01-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaJournal of Ethnopharmacology (JOURNAL)
Identificadores de la revistaISSN: 0378-8741 • E-ISSN: 1872-7573
EditorialElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.118854
PMID39326815
OpenAlexW4402787885
IdiomaEN
Referencias citadas43

The active components of saffron can reduce the expression of inflammatory factors and ameliorate the immunological microenvironment of tumors via the IL-17 signaling pathway, thereby improving the efficacy of immunotherapy for colorectal cancer. This study provides pharmacological support for the application of saffron in enhancing the efficacy of immunotherapy for colorectal cancer

Biological activity · Biology · Cancer · Cancer Immunotherapy · Colorectal cancer · Immunotherapy · In vitro · Pharmacognosy · Signal transduction · Traditional medicine · Medicine · Nigella sativa pharmacological applications · Phytochemistry and biological activity of medicinal plants · Saffron Plant Research Studies · Immunology · Internal Medicine · Oncology · Pharmacology