Integrated phytochemistry and network pharmacology analysis to reveal effective substances and mechanisms of Bushen Quhan Zhiwang decoction in the treatment of rheumatoid arthritis

Datos Bibliográficos

ID14733679
AutoresLiubo Zhang (Beijing University of Chinese Medicine), Liu-Bo Zhang, Yan Yu (0000-0003-4031-252X, China-Japan Friendship Hospital), Yu Yan (0009-0009-6373-2368), Ru Ma (0009-0008-8908-5034, Xian Mental Health Center), Dongxu Li (0000-0002-2630-4286, Shenyang Pharmaceutical University), Dong-Xu Li, Wei-Feng Yin, Weifeng Yin (Beijing University of Chinese Medicine), Qing-Wen Tao, Qingwen Tao (0000-0002-9163-8426, China-Japan Friendship Hospital, autor de correspondencia), Yuan Xu (0000-0002-2341-7971, China-Japan Friendship Hospital, autor de correspondencia)
Año2024
Volumen325
Páginas117897
Fecha de publicación2024-05-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaJournal of Ethnopharmacology (JOURNAL)
Identificadores de la revistaISSN: 0378-8741 • E-ISSN: 1872-7573
EditorialElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.117897
PMID38336180
OpenAlexW4391617129
IdiomaEN
Citas recibidas2
Referencias citadas38

This study revealed the key active components and metabolites of BQZD. BQZD exhibits bone-protective effects via TRAF6/p38/JNK MAPK pathway, which may be associated with 9 absorbed components and 1 metabolite

Active metabolite · Arthritis · Decoction · MAPK/ERK pathway · Metabolite · Osteoclast · p38 mitogen-activated protein kinases · Receptor · Rheumatoid arthritis · Signal transduction · Traditional medicine · Bone Metabolism and Diseases · Chemistry · Medicine · Natural product bioactivities and synthesis · Rheumatoid Arthritis Research and Therapies · Biochemistry · Internal Medicine · Pharmacology