HIV and Aging

State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of Aids Research by the HIV and Aging Working Group

Datos Bibliográficos

ID23387753
AutoresKevin P High (Atrium Health Wake Forest Baptist, autor de correspondencia), Mark Brennan-Ing, Mark Brennan‐ing (0000-0001-9071-6659), David B Clifford (0000-0001-5719-1555, Washington University in St. Louis), Marsha H Cohen (0000-0002-1351-9624, Rush University), Mardge H Cohen, JUDITH S CURRIER (0000-0003-4279-4737, University of California, Los Angeles), Judith Currier, Steven G Deek (0000-0001-6371-747X, University of California, San Francisco), Steven G Deeks, Sherry Deren (New York University), Rita B Effros (0000-0003-0636-3569, University of California, Los Angeles), Kelly A Gebo (0000-0003-4010-398X, Atrium Health Wake Forest Baptist, autor de correspondencia), Kelly Gebo, Jorg J Goronzy (0000-0001-7670-1856, Stanford University), Amy C Justice (0000-0003-0139-5502, Washington University in St. Louis), Alan Landay (0000-0001-9645-1356, Rush University Medical Center), Jules Levin (University of California, Los Angeles), Paolo G Miotti, Paolo Miotti (National Institutes of Health), Robert J Munk (AIDS United), Heidi Nass, Heidi M Nass (Atrium Health Wake Forest Baptist, autor de correspondencia), Charles R Rinaldo (0000-0002-9194-3164, University of Pittsburgh), Michael G Shlipak (0000-0002-9559-204X, San Francisco VA Medical Center), Russell P Tracy (0000-0002-0080-2420, University of Vermont), Russell Tracy, Victor Valcour (0000-0003-1981-4832, University of California, Los Angeles), David E Vance (0000-0002-0498-6263, University of California, San Francisco), Jeremy D Walston, Jeremy Walston (0000-0002-6965-2723, Atrium Health Wake Forest Baptist, autor de correspondencia), Paul Volberding, Paul A Volberding (0000-0002-9608-192X, San Francisco VA Medical Center)
Año2012
Volumen60
NúmeroSupplement 1
PáginasS1-S18
Fecha de publicación2012-07-01
Peer ReviewedSí
Open AccessNo
TipoARTICLE
RevistaJAIDS Journal of Acquired Immune Deficiency Syndromes (JOURNAL)
Identificadores de la revistaISSN: 1525-4135 • E-ISSN: 1944-7884
EditorialOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/qai.0b013e31825a3668
PMID22688010
PMCIDPMC3413877
OpenAlexW1992604744
IdiomaEN
Citas recibidas69
Referencias citadas76

HIV risk behaviors, susceptibility to HIV acquisition, progression of disease after infection, and response to antiretroviral therapy all vary by age. In those living with HIV, current effective treatment has increased the median life expectancy to >70 years of age. Biologic, medical, individual, social, and societal issues change as one ages with HIV infection, but there has been only a small amount of research in this field. Therefore, the Office of AIDS Research of the National Institutes of Health commissioned a working group to develop an outline of the current state of knowledge and areas of critical need for research in HIV and Aging; the working groups' findings and recommendations are summarized in this report. Key overarching themes identified by the group included the following: multimorbidity, polypharmacy, and the need to emphasize maintenance of function; the complexity of assessing HIV versus treatment effects versus aging versus concurrent disease; the inter-related mechanisms of immune senescence, inflammation, and hypercoagulability; the utility of multivariable indices for predicting outcomes; a need to emphasize human studies to account for complexity; and a required focus on issues of community support, caregivers, and systems infrastructure. Critical resources are needed to enact this research agenda and include expanded review panel expertise in aging, functional measures, and multimorbidity, and facilitated use and continued funding to allow long-term follow-up of cohorts aging with HIV.

Disease · Environmental health · Human immunodeficiency virus (HIV) · Intensive care medicine · Life expectancy · Polypharmacy · Population · HIV Research and Treatment · HIV-related health complications and treatments · HIV/AIDS Research and Interventions · Immunology · Medicine · Gerontology