Genetic variants of serum butyrylcholinesterase in Chilean Mapuche Indians

Datos Bibliográficos

ID8316099
AutoresM Acuña (0000-0002-4100-1873, University of Chile, autor de correspondencia), L Eaton (Adolfo Ibáñez University), N R Ramírez, Nicolás Ramírez (0000-0002-0444-8094, University of Chile), L Cifuentes (0000-0001-7552-0279, University of Chile), Elena Llop (0009-0000-0675-2076, University of Chile)
Año2003
Volumen121
Número1
Páginas81-85
Fecha de publicación2003-04-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaAmerican Journal of Physical Anthropology (JOURNAL)
Identificadores de la revistaISSN: 0002-9483 • E-ISSN: 1096-8644
EditorialWiley (PUBLISHER • GB)
DOI10.1002/ajpa.10222
PMID12687586
OpenAlexW1969543921
IdiomaEN
Citas recibidas4
Referencias citadas17

We estimated the frequencies of serum butyrylcholinesterase (BChE) alleles in three tribes of Mapuche Indians from southern Chile, using enzymatic methods, and we estimated the frequency of allele BCHE*K in one tribe using primer reduced restriction analysis (PCR‐PIRA). The three tribes have different degrees of European admixture, which is reflected in the observed frequencies of the atypical allele BCHE*A : 1.11% in Huilliches, 0.89% in Cuncos, and 0% in Pehuenches. This result is evidence in favor of the hypothesis that BCHE*A is absent in native Amerindians. The frequencies of BCHE*F were higher than in most reported studies (3.89%, 5.78%, and 4.41%, respectively). These results are probably due to an overestimation of the frequency of allele BCHE*F , since none of the 20 BCHE UF individuals (by the enzymatic test) individuals analyzed showed either of the two DNA base substitutions associated with this allele. Although enzymatic methods rarely detect the presence of allele BCHE*K , PCR‐PIRA found the allele in an appreciable frequency (5.76%), although lower than that found in other ethnic groups. Since observed frequencies of unusual alleles correspond to estimated percentages of European admixture, it is likely that none of these unusual alleles were present in Mapuche Indians before the arrival of Europeans. Am J Phys Anthropol 121:000–000, 2003. © 2003 Wiley‐Liss, Inc

Acetylcholinesterase · Allele · Allele frequency · Biology · Butyrylcholinesterase · Enzyme · Gene · Primer (cosmetics) · Biochemistry · Chemistry · Cholinesterase and Neurodegenerative Diseases · Computational Drug Discovery Methods · Genetics · Pesticide Exposure and Toxicity