Joel E Dimsdale
Biographic Data
| ID | 129745 |
|---|---|
| NAME | Joel E Dimsdale |
| GIVEN NAMES | Joel E |
| FAMILY NAME | Dimsdale |
| SIGNATURE | DIMSDALE J E |
| AFFILIATIONS | University of California San Diego |
| VERIFIED | No |
| TOTAL WORKS | 85 |
| TOTAL CITATIONS | 31 |
| AUTHOR COUNT | 85 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1978 |
| LATEST PUBLICATION YEAR | 2021 |
| H-INDEX | 2 |
Dark Persuasion: A History of Brainwashing from Pavlov to Social Media
Dark Persuasion: A History of Brainwashing from Pavlov to Social Media
The Relationship Between Circulating Interleukin-6 Levels and Future Health Service Use in Dementia Caregivers
OBJECTIVE: Older adults are among the most frequent users of emergency departments (EDs). Nonspecific symptoms, such as fatigue and widespread pain, are among the most common symptoms in patients admitted at the ED. Interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) are inflammation biomarkers associated with chronic stress (i.e., dementia caregiving) and nonspecific symptoms. This study aimed to determine whether IL-6 and TNF-α were prospe…
Research on Somatization and Somatic Symptom Disorders: Ars longa, vita brevis
The new Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition defines somatic symptom and related disorders as long-standing somatic symptoms that are associated with disproportionate thoughts, feelings, and behaviors, irrespective of whether or not a medical cause for these symptoms can be determined. In this Special Section of Psychosomatic Medicine , several articles address diagnostic issues and the central nervous system corre…
Engagement in Pleasant Leisure Activities and Blood Pressure: A 5-Year Longitudinal Study in Alzheimer Caregivers
OBJECTIVE: Elevated blood pressure is a significant public health concern, particularly given its association with cardiovascular disease risk, including stroke. Caring for a loved one with Alzheimer disease has been associated with physical health morbidity, including higher blood pressure. Engagement in adaptive coping strategies may help prevent blood pressure elevation in this population. This 5-year longitudinal study examined whether greate…
Anatomy of malice: The enigma of the Nazi war criminals
When the ashes had settled after World War II and the Allies convened an international war crimes trial in Nuremberg, a psychiatrist, Douglas Kelley, and a psychologist, Gustave Gilbert, tried to fathom the psychology of the Nazi leaders, using extensive psychiatric interviews, IQ tests, and Rorschach inkblot tests. Never before nor since has there been such a detailed study of governmental leaders who orchestrated mass killings. Before the war c…
Longitudinal Relationship of Low Leisure Satisfaction but not Depressive Symptoms With Systemic Low-Grade Inflammation in Dementia Caregivers
Lower satisfaction with leisure activities is related to higher low-grade systemic inflammation. This knowledge may provide a promising way of improving cardiovascular health in dementia caregivers through behavioral activation treatments targeting low leisure satisfaction
Association of In Vivo β-Adrenergic Receptor Sensitivity With Inflammatory Markers in Healthy Subjects
OBJECTIVE: Several stress-related states and conditions that are considered to involve sympathetic overactivation are accompanied by increased circulating levels of inflammatory immune markers. Prolonged sympathetic overactivity involves increased stimulation of the β-adrenergic receptor (β-AR). Although prior research suggests that one mechanism by which sympathetic stimulation may facilitate inflammation is via β-AR activation, little work has …
Recalling, Reporting, and Thinking About Diagnoses
Psychosomatic Medicine: November/December 2012 - Volume 74 - Issue 9 - p 882 doi: 10.1097/PSY.0b013e3182738739
Effect of Chronic Dementia Caregiving and Major Transitions in the Caregiving Situation on Kidney Function: A Longitudinal Study
OBJECTIVE: To estimate the glomerular filtration rate (GFR) in relation to the chronic stress of dementia caregiving and major transitions in the caregiving situation. METHODS: We longitudinally assessed 119 people serving as caregivers for their spouses with Alzheimer's disease and 58 noncaregiving controls for a period of up to 3 years (mean of 2.8 assessments per participant). At baseline, the mean (standard deviation [SD]) age of all particip…
Carotid Plaque in Alzheimer Caregivers and the Role of Sympathoadrenal Arousal
OBJECTIVES: To test the hypothesis that those who provide care for a spouse diagnosed with Alzheimer's disease would have increased prevalence of carotid artery plaque compared with noncaregiving controls and that prolonged sympathoadrenal arousal to acute stress would relate to this difference. Providing care for a spouse with Alzheimer's disease has been associated with an increased risk of coronary heart disease, potentially due to the impact …
Depressed Mood and Flow-Mediated Dilation: A Systematic Review and Meta-Analysis
OBJECTIVE: This systematic and quantitative review evaluates the literature on associations between depressed mood and flow-mediated dilation (FMD), a measure of endothelial function, in adults. METHODS: Published English-language articles (through December 2010) were identified from literature searches, assessed for data extraction, and evaluated for quality. RESULTS: The literature includes cross-sectional (n = 9) and retrospective examinations…
Effects of Alzheimer Caregiving on Allostatic Load
This study aimed to determine if Alzheimer caregivers have increased allostatic load compared to non-caregivers. Potential psychological moderators (mastery, depression, and role overload) of the relationship between caregiving status and allostatic load were also explored. Eighty-seven caregivers and 43 non-caregivers underwent biological assessment of allostatic load and psychological assessments. Caregivers had significantly higher allostatic …
Overnight Changes of Immune Parameters and Catecholamines Are Associated With Mood and Stress
Objectives: To test the hypothesis that a nocturnal decrease of secretion of inflammation markers and catecholamines would be associated with mood and stress variables even after controlling for objective sleep variables. Methods: A total of 130 healthy volunteers participated in this study, spending 2 nights in the Gillin Laboratory of Sleep and Chronobiology at the University of California, San Diego, General Clinical Research Center. Blood sam…
Adverse Impact of Mood on Flow-Mediated Dilation
OBJECTIVE: To examine the impact of mood states on endothelial function, as measured noninvasively by brachial artery flow-mediated dilation (FMD). Substantial literature indicates that negative mood is linked to cardiovascular disease (CVD). However, the mechanisms underlying this relationship are not well defined. CVD is often preceded by dysfunction of the endothelium. METHODS: Healthy adults (n = 70; mean age, 36 years) completed the Profile …
Psychiatry's Diagnostic and Statistical Manual Dilemmas: Can Cartography Help
Everyday Discrimination and Nocturnal Blood Pressure Dipping in Black and White Americans
These findings suggest that experiences of everyday discrimination are associated with less nocturnal SBP and DBP dipping above and beyond the effect of known covariates. The use of multiple ABPM sessions may facilitate the detection of relationships between psychological variables and BP dipping
Racial Differences in the Impact of Social Support on Nocturnal Blood Pressure
OBJECTIVE: To investigate whether black and white adults benefit similarly from perceived social support in relation to blood pressure (BP) dipping during sleep. METHODS: The Interpersonal Support Evaluation List (ISEL, 12-item version), which measures the perceived availability of several types of functional social support, was examined for interactive effects with race on dipping of mean arterial pressure (MAP), systolic blood pressure (SBP), a…
Psychological Stress and Cardiovascular Disease
A Biological Substrate for Somatoform Disorders: Importance of Pathophysiology
Somatoform disorders are troubling to both patients and physicians. The diagnosis regrettably relies on the presence of subjective distress in the absence of objective findings. As a result, there is always the possibility that a diagnosis will be "missed." There is a clear underlying physiology of distress, which implies that there is a two-way street--both psychosomatic and somatopsychic in terms of production and experience of somatoform sympt…
Somatic Presentations—A Challenge for DSM-V
Dimsdale, Joel E. MD; Patel, Vikram MB; Xin, Yu MD; Kleinman, Arthur MD Author Information
Combination of Caregiving Stress and Hormone Replacement Therapy is Associated With Prolonged Platelet Activation to Acute Stress Among Postmenopausal Women
Objective: To investigate the combined effects of caregiving and hormone replacement therapy (HRT) on platelet hyperactivity to acute psychological stress. Both HRT and the chronic stress of caregiving have been associated with increased cardiovascular risk, potentially through a mechanism of platelet hyperactivity. Methods: A total of 78 elderly postmenopausal women (51 caregivers (CG) and 27 noncaregivers (NC)) were assessed for platelet activa…
Spousal Caregivers of Patients With Alzheimer's Disease Show Longitudinal Increases in Plasma Level of Tissue-Type Plasminogen Activator Antigen
OBJECTIVE: To determine if caregivers of spouses with Alzheimer's disease demonstrate greater increase in tissue plasminogen activator (t-PA) antigen relative to noncaregiving controls. Caring for a spouse with Alzheimer's disease has been associated with increased mortality and reduced time to developing cardiovascular disease (CVD), possibly due to impaired fibrinolysis resulting from chronic stress. METHODS: Annual in-home assessments of plasm…
Ethnicity, Perceived Discrimination, and Vascular Reactivity to Phenylephrine
Objectives: This study examined relationships among ethnicity, perceived discrimination, and vascular reactivity to phenylephrine (PE). Methods: Seventy-six white patients and 46 black patients were studied at an inpatient clinical research center in response to a bolus intravenous injection of 100 μg PE. Self-report questionnaires assessed perceived discrimination. Results: After controlling for body surface area, number of cigarettes smoked, an…
Age and Ethnicity Differences in Short-Term Heart-Rate Variability
OBJECTIVE: Hypertension is more frequent and more severe in older individuals and in African Americans. Differences in autonomic nervous system activity might contribute to these differences. Autonomic effects on the heart can be studied noninvasively through analysis of heart rate variability (HRV). We examined the effects of age and ethnicity on HRV. METHODS: We studied 135 subjects (57 African Americans and 78 Caucasian Americans), aged 23 to …
Everyday Discrimination and Nocturnal Blood Pressure Dipping in Black and White Americans
These findings suggest that experiences of everyday discrimination are associated with less nocturnal SBP and DBP dipping above and beyond the effect of known covariates. The use of multiple ABPM sessions may facilitate the detection of relationships between psychological variables and BP dipping
Effects of Alzheimer Caregiving on Allostatic Load
This study aimed to determine if Alzheimer caregivers have increased allostatic load compared to non-caregivers. Potential psychological moderators (mastery, depression, and role overload) of the relationship between caregiving status and allostatic load were also explored. Eighty-seven caregivers and 43 non-caregivers underwent biological assessment of allostatic load and psychological assessments. Caregivers had significantly higher allostatic …
Characteristics of repeat trauma patients, San Diego County
Data on 22,312 admissions to the San Diego County Trauma System were used to identify 185 trauma patients admitted repeatedly to trauma units. These patients were compared with the entire group of nonrepeating trauma patients admitted during the 80-month period of the study. In comparison with nonrepeaters, the repeaters were younger, were more often men, were more often Black, and were much more frequently victims of assault. Forty-eight percent…
Psychological factors in cardiovascular disorders
Emotional Correlates of Type A Behavior Pattern
Dimsdale, Joel E. MD; Hackett, Thomas P. MD; Block, Peter C. MD; Hutter, Adolph M. Jr. MD Author Information
Type A personality assessment
Department of Psychiatry Harvard Medical School Massachusetts General Hospital Boston, Massachusetts 02114 Received for publication October 4, 1977
Stress at work
Short-Term Catecholamine Response to Psychological Stress1
The recent development of radioenzymatic assays for plasma catecholamines and of highly portable nonobtrusive blood withdrawal pumps makes possible the investigation of the physiological response to actual stress. However because the half-life of plasma catecholamines is so brief, meticulous care must be taken to obtain blood samples consistently vis-a-vis the stress immersion experience. These points are demonstrated in a study of ten young phys…
The Risk of Type A Mediated Coronary Artery Disease in Different Populations
Using angiographic evidence of coronary artery disease, we have examined whether certain populations were particularly susceptible for risk engendered by Type A personality. Two hundred three men were studied with the Jenkins Activity Surveys; 103 of them were also studied with the Rosenman semistructured interview. The extent of vessel disease was found unrelated to Type A in each of the three ethnic groups studied--Irish Catholic, Italian Catho…
Variability of Plasma Lipids in Response to Emotional Arousal
Although plasma lipid levels are assumed to reflect the individual's constitutional or nutritional status, many studies have found that plasma lipids are noticeably influenced by short-term emotional arousal. Sixty such studies are reviewed. These studies span a remarkable breadth of stressful situations, such as from viewing disturbing films to taking examinations or participating in military training courses. Free fatty acid levels were almost …
Psychological factors in cardiovascular disorders
Epinephrine Mediated Increases in Plasma Cholesterol
The effect of physiological elevations of plasma epinephrine levels on plasma cholesterol levels was studied in ten cynomolgus monkeys. Epinephrine was increased 5 days/week for 6 hr/day. After 2 weeks, the cholesterol levels increased on the average of 15 mg% (p less than 0.01)
Critical Issues in Behavioral Medicine
Generalizing from Laboratory Studies to Field Studies of Human Stress Physiology
In studying physiologic responses to behavioral stressors, there are two competing strategies. Laboratory studies offer greater experimental control but less provocation. Field studies provide poorer experimental control but potentially greater provocation. Despite these differences, comparison within subjects of neuroendocrine responses to these different settings has not been performed. We studied 11 healthy young men in the field during public…
Suppressed anger and blood pressure: The effects of race, sex, social class, obesity, and age
We studied 572 men and women who participated in a blood pressure screening program at a government unemployment office. Before having their blood pressures taken, the subjects completed a brief questionnaire that included two items measuring conflict over anger expression. Information was also obtained on obesity, race, sex, social class, and age. Across all subjects, systolic blood pressure was found to be significantly related to suppressed an…
The stress interview as a tool for examining physiological reactivity
Most studies of cardiovascular reactivity utilize tasks that are highly standardized and controlled. However, there is some concern whether the information obtained from these tasks is relevant to understanding the cardiovascular responses to behavioral stimuli encountered in real life. Historically, various forms of a stress interview have been used to examine physiological concomitants of emotional arousal. However, these tools fell into disuse…
Cultural variations in response to painful stimuli
This review updates the literature on cultural differences in response to laboratory-induced pain. Thirteen studies were located, and there was great diversity among the investigations with regard to racial and ethnic groups studied, methods of pain induction, and experimental outcome. There appear to be no racial/ethnic differences in the ability to discriminate painful stimuli. More difficult to assess is cultural variation in the response to l…
A quantitative technique for characterizing tasks in psychophysiology studies
A model was designed to specify the components of blood pressure (BP) in a reactivity study. The model considered six components for BP in response to tasks: the average resting BP across all subjects, a given subject's deviation from that average, the average task effect for a specific task, a given subject's deviation from the average task effect, the average effect of repeated assessments of BP within a given task, and an error term. The model…
Psychosomatic Medicine—Looking Forward and Backward
Consultation/liaison psychiatry utilization patterns in different cultural groups
This study examined the effect of cross-cultural factors on psychiatric consultations in a general hospital. Using a retrospective case review, 476 patients receiving a psychiatric consultation were contrasted with 14,620 who did not receive a psychiatric consultation. The rate of psychiatric referral was lower for Hispanics compared with Anglos, blacks, and Asians (p less than 0.001). The reason for requesting psychiatric consultation was also d…
The promise of adrenergic receptor studies in psychophysiologic research II: Applications, limitations, and progress
For years research in fields such as biologic psychiatry and hypertension has benefited from the use of receptor measures. It is only recently however, that investigators in the field of psychosomatic medicine have taken advantage of this methodology. Much of this research revolves around discerning the roles that adrenergic receptors play in stressful events and stress-related behaviors. Thus far, psychosomatic studies have focused primarily on …
The Fog of Science
Social Support--A Lifeline in Stormy Times
Characteristics of repeat trauma patients, San Diego County
Data on 22,312 admissions to the San Diego County Trauma System were used to identify 185 trauma patients admitted repeatedly to trauma units. These patients were compared with the entire group of nonrepeating trauma patients admitted during the 80-month period of the study. In comparison with nonrepeaters, the repeaters were younger, were more often men, were more often Black, and were much more frequently victims of assault. Forty-eight percent…
Ethnic Differences in Analgesic Consumption for Postoperative Pain
OBJECTIVE: To examine the influence of patient ethnicity on receipt of postoperative analgesia. METHOD: Chart review of 250 consecutive patients hospitalized for open reduction and internal fixation of a limb fracture. Analgesics consumption in the postoperative period was measured in terms of morphine equivalents. RESULTS: There were significant differences (p < .005) in analgesics administered to black, Hispanic, and white patients. Whites rece…
Pointillism and Science
Arch of Fire: A Child in Nazi Germany
A Review of the Review Process
Plasma Catecholamine and Lymphocyte beta2 -adrenergic Receptor Alterations in Elderly Alzheimer Caregivers under Stress
OBJECTIVE: The purpose of this study was to determine the effects of chronic stress on beta-adrenergic physiology in elderly spousal caregivers to Alzheimer patients. METHODS: Thirty-seven elderly spousal caregivers and matched noncaregiver controls (mean age 73 years, SD = 6) were studied. Life stress categorization (presence of marked threat) covering the previous 6 months was determined using a semistructured interview based on the Psychiatric…
Medicine (67 works) · Psychology (62 works) · Internal Medicine (45 works) · Internal Medicine (43 works) · Clinical Psychology (29 works) · Psychiatry (23 works) · Stress Responses and Cortisol (19 works) · Cardiac Health and Mental Health (18 works) · Blood pressure (17 works) · Disease (14 works)