Association of In Vivo β-Adrenergic Receptor Sensitivity With Inflammatory Markers in Healthy Subjects

Bibliographic Data

ID19306161
AuthorsFrank Euteneuer (0000-0001-9346-4346, University of California System, corresponding author), Paul J Mills (0000-0003-4263-7686), Winfried Rief (0000-0002-7019-2250), Michael G Ziegler (0000-0002-0841-350X), Joel E Dimsdale
Year2012
Volume74
Issue3
Pages271-277
Publication date2012-04-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/psy.0b013e318245d762
PMID22366585
PMCIDPMC3365878
OpenAlexW2090027565
LanguageEN
Citations received2
References cited88

OBJECTIVE: Several stress-related states and conditions that are considered to involve sympathetic overactivation are accompanied by increased circulating levels of inflammatory immune markers. Prolonged sympathetic overactivity involves increased stimulation of the β-adrenergic receptor (β-AR). Although prior research suggests that one mechanism by which sympathetic stimulation may facilitate inflammation is via β-AR activation, little work has focused on the relationship between circulating inflammatory immune markers and β-AR function within the human body (in vivo). We examined whether decreased β-AR sensitivity, an indicator of prolonged β-adrenergic overactivation and a physiological component of chronic stress, is related to elevated levels of inflammatory immune markers. METHODS: Ninety-three healthy participants aged 19 to 51 years underwent the chronotropic 25 dose isoproterenol test to determine in vivo β-AR function. Circulating levels of C-reactive protein, interleukin 6, and soluble tumor necrosis factor receptor 1 were determined. RESULTS: β-AR sensitivity was lower in people with higher C-reactive protein concentrations (r = 0.326, p = .003). That relationship remained significant after controlling for sociodemographic and health variables such as age, sex, ethnicity, body mass index, mean arterial blood pressure, heart rate, leisure-time exercise, and smoking status. No significant relationship was found between chronotropic 25 dose and interleukin 6 or soluble tumor necrosis factor receptor 1. CONCLUSIONS: This study demonstrates a link between in vivo β-adrenergic receptor function and selected circulating inflammatory markers (CRP) in humans. Future studies in specific disease states may be promising

Biology · Blood pressure · Body mass index · Chronotropic · Heart rate · Immune system · In vivo · Inflammation · Receptor · Stimulation · Tumor necrosis factor alpha · Cancer, Stress, Anesthesia, and Immune Response · Endocrinology · Immunology · Internal Medicine · Medicine · Stress Responses and Cortisol · Vagus Nerve Stimulation Research

Tools

Open DOISci-Hub