Fruhling Rijsdijk
Biographic Data
| ID | 1662007 |
|---|---|
| NAME | Fruhling Rijsdijk |
| GIVEN NAMES | Fruhling |
| FAMILY NAME | Rijsdijk |
| SIGNATURE | RIJSDIJK F |
| AFFILIATIONS | King's College London |
| ORCID | 0000-0003-4762-2803 |
| VERIFIED | Yes |
| TOTAL WORKS | 19 |
| TOTAL CITATIONS | 53 |
| AUTHOR COUNT | 19 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2002 |
| LATEST PUBLICATION YEAR | 2024 |
| H-INDEX | 3 |
Genetic and Environmental Influences on Sexual Orientation
Existing evidence indicates genetic and non-genetic influences on sexual orientation; however, the possibility of gene-environment interplay has not been previously formally tested despite theories indicating this. Using a Finnish twin cohort, this study investigated whether childhood gender nonconformity and early-life adversities independently moderated individual differences in sexual orientation and childhood gender nonconformity, the relatio…
Gene–environment interplay linking perceived parental supervision and peer drunkenness with Chinese adolescent alcohol initiation
Following 602 Chinese twin pairs (48% male, all Han ethnicity) from primarily lower-than-average socioeconomic status families from early to mid-adolescence (M s = 12 and 15 in 2006 and 2009), this study investigated gene–environment interplay between perceived parental supervision, peer drunkenness, and adolescent alcohol initiation. For alcohol initiation, shared environmental influences were initially negligible but became substantial. Genetic…
Causal Influences of Same-Sex Attraction on Psychological Distress and Risky Sexual Behaviors
Although health disparities among same-sex attracted compared to heterosexual individuals are typically explained by minority stress, there is limited evidence for a causal effect. This study investigated whether same-sex attraction was causally associated with psychological distress and risky sexual behavior using sociosexual behavior as a proxy. The sample comprised monozygotic and dizygotic twins and their non-twin siblings ( n = 2036, 3780 an…
Parental criticism and adolescent internalising symptoms
BACKGROUND: Parental criticism is correlated with internalising symptoms in adolescent offspring. This correlation could in part reflect their genetic relatedness, if the same genes influence behaviours in both parents and offspring. We use a Children-of-Twins design to assess whether parent-reported criticism and offspring internalising symptoms remain associated after controlling for shared genes. To aid interpretation of our results and those …
Research Review
BACKGROUND: Genetic influences are ubiquitous as virtually all phenotypes and most exposures typically classified as environmental have been found to be heritable. A polygenic score summarises the associations between millions of genetic variants and an outcome in a single value for each individual. Ever lowering costs have enabled the genotyping of many samples relevant to child psychology and psychiatry research, including cohort studies, leadi…
A genetically informed Registered Report on adverse childhood experiences and mental health
Children who experience adversities have an elevated risk of mental health problems. However, the extent to which adverse childhood experiences (ACEs) cause mental health problems remains unclear, as previous associations may partly reflect genetic confounding. In this Registered Report, we used DNA from 11,407 children from the United Kingdom and the United States to investigate gene–environment correlations and genetic confounding of the associ…
Reciprocal links between anxiety sensitivity and obsessive–compulsive symptoms in youth
BACKGROUND: Anxiety sensitivity, the tendency to fear the symptoms of anxiety, is a key risk factor for the development anxiety disorders. Although obsessive-compulsive disorder was previously classified as an anxiety disorder, the prospective relationship between anxiety sensitivity and obsessive-compulsive symptoms (OCS) has been largely overlooked. Furthermore, a lack of genetically informative studies means the aetiology of the link between a…
Genetic Overlap Between Type 2 Diabetes and Depression in a Sri Lankan Population Twin Sample
OBJECTIVE: Results from twin studies examining the genetic overlap between type 2 diabetes and depression are currently inconclusive. This question has not been addressed in non-Western populations. We aimed to examine whether there are common genetic factors between type 2 diabetes and depression in a Sri Lankan population using genetic model-fitting analysis. METHOD: The Colombo Twin and Singleton Study-Phase 2 consists of 2019 singletons, and …
Mental Health Disparities Mediating Increased Risky Sexual Behavior in Sexual Minorities
Increased risky sexual behavior in sexual minorities relative to heterosexual individuals may be partly explained by mental health disparities, and both factors may be further jointly influenced by common genetic and environmental factors. However, these relationships have not been previously investigated. The objectives of the present study were to investigate mental health disparities as a mediator of the relationship between sexual orientation…
The Colombo Twin and Singleton Follow-up Study
MetS was highly prevalent in twins, and especially high in singletons, whereas the prevalence of mental disorders was low, but consistent with local estimates. The high levels of raised fasting plasma glucose and central obesity were particularly concerning, and warrant national diabetes prevention programmes
Genetics of co-developing conduct and emotional problems during childhood and adolescence
The Covariation of Antisocial Behavior and Substance Use in Adolescence
Multivariate genetic studies have revealed genetic correlations between antisocial behavior ( ASB ) and substance use ( SU ). However, ASB is heterogeneous, and it remains unclear whether all forms are similarly related to SU . The present study examines links between cannabis use, alcohol consumption, and aggressive and delinquent forms of ASB using a behavioral genetic approach. Participants were 1,688 adolescents (482 monozygotic twins, 852 di…
Rethinking shared environment as a source of variance underlying attention-deficit/hyperactivity disorder symptoms
Burt (2009) recently published a meta-analysis of twin studies on behaviors associated with childhood psychopathologies, concluding that the finding that traits associated with attention-deficit/hyperactivity disorder (ADHD) were the only behaviors that did not show a significant influence of shared environment (C) was surprising. We agree, highlighting four methodological issues that may account for this finding: (a) the use of nonlinear transfo…
A link between altruism and sexual selection
Altruistic behaviour raises major questions for psychology and biology. One hypothesis proposes that human altruistic behaviour evolved as a result of sexual selection. Mechanisms that seek to explain how sexual selection works suggest genetic influence acting on both the mate preference for the trait and the preferred trait itself. We used a twin study to estimate whether genetic effects influenced responses to psychometric scales measuring mate…
Neuroticism and Morning Cortisol Secretion
Neuroticism is widely used as an explanatory concept in etiological research of psychopathology. To clarify what neuroticism actually represents, we investigated the phenotypic and genetic relationship between neuroticism and the morning cortisol secretion. In the current classic twin study, 125 female twin pairs (74 monozygotic and 51 dizygotic pairs) participated. For each participant, 4 different neuroticism scores were available to calculate …
Pathways to childhood depressive symptoms
Childhood depressive conditions have been explored from multiple theoretical approaches but with few empirical attempts to address the interrelationships among these different domains and their combined effects. In the present study, the authors examined different pathways through which social, cognitive, and genetic risk factors may be expressed to influence depressive symptoms in 300 pairs of child twins from a longitudinal study. Path analysis…
Genes Making One Feel Blue in the Flow of Daily Life
OBJECTIVE: Individual differences in stress reactivity constitute a crucially important mechanism of risk for depression. Because stress can be conceptualized as the continuous occurrence of minor daily hassles, this study focused on emotional reactivity to stress in the flow of daily life and examined to what degree individual differences in emotional reactivity could be explained by genetic and/or environmental factors. METHODS: Two hundred sev…
Analytic approaches to twin data using structural equation models
The classical twin study is the most popular design in behavioural genetics. It has strong roots in biometrical genetic theory, which allows predictions to be made about the correlations between observed traits of identical and fraternal twins in terms of underlying genetic and environmental components. One can infer the relative importance of these 'latent' factors (model parameters) by structural equation modelling (SEM) of observed covariances…
Temporal and Reciprocal Relationship Between Iadl/ADL Disability and Depressive Symptoms in Late Life
A strong association between functional disability and depressive symptoms in older people has frequently been reported. Some studies attribute this association to the disabling effects of depression, others to the depressogenic effects of physical health-related disability. The authors examined the reciprocal effects between depressive symptoms and functional disability and their temporal character in a community-based cohort of 753 older people…
Temporal and Reciprocal Relationship Between Iadl/ADL Disability and Depressive Symptoms in Late Life
A strong association between functional disability and depressive symptoms in older people has frequently been reported. Some studies attribute this association to the disabling effects of depression, others to the depressogenic effects of physical health-related disability. The authors examined the reciprocal effects between depressive symptoms and functional disability and their temporal character in a community-based cohort of 753 older people…
Pathways to childhood depressive symptoms
Childhood depressive conditions have been explored from multiple theoretical approaches but with few empirical attempts to address the interrelationships among these different domains and their combined effects. In the present study, the authors examined different pathways through which social, cognitive, and genetic risk factors may be expressed to influence depressive symptoms in 300 pairs of child twins from a longitudinal study. Path analysis…
Mental Health Disparities Mediating Increased Risky Sexual Behavior in Sexual Minorities
Increased risky sexual behavior in sexual minorities relative to heterosexual individuals may be partly explained by mental health disparities, and both factors may be further jointly influenced by common genetic and environmental factors. However, these relationships have not been previously investigated. The objectives of the present study were to investigate mental health disparities as a mediator of the relationship between sexual orientation…
A genetically informed Registered Report on adverse childhood experiences and mental health
Children who experience adversities have an elevated risk of mental health problems. However, the extent to which adverse childhood experiences (ACEs) cause mental health problems remains unclear, as previous associations may partly reflect genetic confounding. In this Registered Report, we used DNA from 11,407 children from the United Kingdom and the United States to investigate gene–environment correlations and genetic confounding of the associ…
Analytic approaches to twin data using structural equation models
The classical twin study is the most popular design in behavioural genetics. It has strong roots in biometrical genetic theory, which allows predictions to be made about the correlations between observed traits of identical and fraternal twins in terms of underlying genetic and environmental components. One can infer the relative importance of these 'latent' factors (model parameters) by structural equation modelling (SEM) of observed covariances…
Temporal and Reciprocal Relationship Between Iadl/ADL Disability and Depressive Symptoms in Late Life
A strong association between functional disability and depressive symptoms in older people has frequently been reported. Some studies attribute this association to the disabling effects of depression, others to the depressogenic effects of physical health-related disability. The authors examined the reciprocal effects between depressive symptoms and functional disability and their temporal character in a community-based cohort of 753 older people…
Genes Making One Feel Blue in the Flow of Daily Life
OBJECTIVE: Individual differences in stress reactivity constitute a crucially important mechanism of risk for depression. Because stress can be conceptualized as the continuous occurrence of minor daily hassles, this study focused on emotional reactivity to stress in the flow of daily life and examined to what degree individual differences in emotional reactivity could be explained by genetic and/or environmental factors. METHODS: Two hundred sev…
Pathways to childhood depressive symptoms
Childhood depressive conditions have been explored from multiple theoretical approaches but with few empirical attempts to address the interrelationships among these different domains and their combined effects. In the present study, the authors examined different pathways through which social, cognitive, and genetic risk factors may be expressed to influence depressive symptoms in 300 pairs of child twins from a longitudinal study. Path analysis…
Neuroticism and Morning Cortisol Secretion
Neuroticism is widely used as an explanatory concept in etiological research of psychopathology. To clarify what neuroticism actually represents, we investigated the phenotypic and genetic relationship between neuroticism and the morning cortisol secretion. In the current classic twin study, 125 female twin pairs (74 monozygotic and 51 dizygotic pairs) participated. For each participant, 4 different neuroticism scores were available to calculate …
Rethinking shared environment as a source of variance underlying attention-deficit/hyperactivity disorder symptoms
Burt (2009) recently published a meta-analysis of twin studies on behaviors associated with childhood psychopathologies, concluding that the finding that traits associated with attention-deficit/hyperactivity disorder (ADHD) were the only behaviors that did not show a significant influence of shared environment (C) was surprising. We agree, highlighting four methodological issues that may account for this finding: (a) the use of nonlinear transfo…
A link between altruism and sexual selection
Altruistic behaviour raises major questions for psychology and biology. One hypothesis proposes that human altruistic behaviour evolved as a result of sexual selection. Mechanisms that seek to explain how sexual selection works suggest genetic influence acting on both the mate preference for the trait and the preferred trait itself. We used a twin study to estimate whether genetic effects influenced responses to psychometric scales measuring mate…
The Covariation of Antisocial Behavior and Substance Use in Adolescence
Multivariate genetic studies have revealed genetic correlations between antisocial behavior ( ASB ) and substance use ( SU ). However, ASB is heterogeneous, and it remains unclear whether all forms are similarly related to SU . The present study examines links between cannabis use, alcohol consumption, and aggressive and delinquent forms of ASB using a behavioral genetic approach. Participants were 1,688 adolescents (482 monozygotic twins, 852 di…
The Colombo Twin and Singleton Follow-up Study
MetS was highly prevalent in twins, and especially high in singletons, whereas the prevalence of mental disorders was low, but consistent with local estimates. The high levels of raised fasting plasma glucose and central obesity were particularly concerning, and warrant national diabetes prevention programmes
Genetics of co-developing conduct and emotional problems during childhood and adolescence
Reciprocal links between anxiety sensitivity and obsessive–compulsive symptoms in youth
BACKGROUND: Anxiety sensitivity, the tendency to fear the symptoms of anxiety, is a key risk factor for the development anxiety disorders. Although obsessive-compulsive disorder was previously classified as an anxiety disorder, the prospective relationship between anxiety sensitivity and obsessive-compulsive symptoms (OCS) has been largely overlooked. Furthermore, a lack of genetically informative studies means the aetiology of the link between a…
Genetic Overlap Between Type 2 Diabetes and Depression in a Sri Lankan Population Twin Sample
OBJECTIVE: Results from twin studies examining the genetic overlap between type 2 diabetes and depression are currently inconclusive. This question has not been addressed in non-Western populations. We aimed to examine whether there are common genetic factors between type 2 diabetes and depression in a Sri Lankan population using genetic model-fitting analysis. METHOD: The Colombo Twin and Singleton Study-Phase 2 consists of 2019 singletons, and …
Mental Health Disparities Mediating Increased Risky Sexual Behavior in Sexual Minorities
Increased risky sexual behavior in sexual minorities relative to heterosexual individuals may be partly explained by mental health disparities, and both factors may be further jointly influenced by common genetic and environmental factors. However, these relationships have not been previously investigated. The objectives of the present study were to investigate mental health disparities as a mediator of the relationship between sexual orientation…
Parental criticism and adolescent internalising symptoms
BACKGROUND: Parental criticism is correlated with internalising symptoms in adolescent offspring. This correlation could in part reflect their genetic relatedness, if the same genes influence behaviours in both parents and offspring. We use a Children-of-Twins design to assess whether parent-reported criticism and offspring internalising symptoms remain associated after controlling for shared genes. To aid interpretation of our results and those …
Research Review
BACKGROUND: Genetic influences are ubiquitous as virtually all phenotypes and most exposures typically classified as environmental have been found to be heritable. A polygenic score summarises the associations between millions of genetic variants and an outcome in a single value for each individual. Ever lowering costs have enabled the genotyping of many samples relevant to child psychology and psychiatry research, including cohort studies, leadi…
A genetically informed Registered Report on adverse childhood experiences and mental health
Children who experience adversities have an elevated risk of mental health problems. However, the extent to which adverse childhood experiences (ACEs) cause mental health problems remains unclear, as previous associations may partly reflect genetic confounding. In this Registered Report, we used DNA from 11,407 children from the United Kingdom and the United States to investigate gene–environment correlations and genetic confounding of the associ…
Gene–environment interplay linking perceived parental supervision and peer drunkenness with Chinese adolescent alcohol initiation
Following 602 Chinese twin pairs (48% male, all Han ethnicity) from primarily lower-than-average socioeconomic status families from early to mid-adolescence (M s = 12 and 15 in 2006 and 2009), this study investigated gene–environment interplay between perceived parental supervision, peer drunkenness, and adolescent alcohol initiation. For alcohol initiation, shared environmental influences were initially negligible but became substantial. Genetic…
Causal Influences of Same-Sex Attraction on Psychological Distress and Risky Sexual Behaviors
Although health disparities among same-sex attracted compared to heterosexual individuals are typically explained by minority stress, there is limited evidence for a causal effect. This study investigated whether same-sex attraction was causally associated with psychological distress and risky sexual behavior using sociosexual behavior as a proxy. The sample comprised monozygotic and dizygotic twins and their non-twin siblings ( n = 2036, 3780 an…
Genetic and Environmental Influences on Sexual Orientation
Existing evidence indicates genetic and non-genetic influences on sexual orientation; however, the possibility of gene-environment interplay has not been previously formally tested despite theories indicating this. Using a Finnish twin cohort, this study investigated whether childhood gender nonconformity and early-life adversities independently moderated individual differences in sexual orientation and childhood gender nonconformity, the relatio…
Psychology (16 works) · Medicine (13 works) · Developmental psychology (12 works) · Clinical Psychology (11 works) · Psychiatry (10 works) · Cognitive Abilities and Testing (9 works) · Biology (8 works) · Child and Adolescent Psychosocial and Emotional Development (8 works) · Genetics (8 works) · Genetics (8 works)