M Uddin
Biographic Data
| ID | 17642 |
|---|---|
| NAME | M Uddin |
| GIVEN NAMES | M |
| FAMILY NAME | Uddin |
| SIGNATURE | UDDIN M |
| AFFILIATIONS | Wayne State University |
| ORCID | 0000-0001-7404-2068 |
| VERIFIED | Yes |
| TOTAL WORKS | 14 |
| TOTAL CITATIONS | 37 |
| WORKS AS AUTHOR | 14 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 2012 |
| LATEST PUBLICATION YEAR | 2024 |
| H-INDEX | 2 |
Clinical characterisation, treatment outcomes, and case fatality risk of patients with different Sars-CoV-2 variants in Bangladesh
Background: Bangladesh underwent four waves of the coronavirus disease 2019 (COVID-19) pandemic. Analysing them is essential for understanding changes in viral behaviour, disease patterns, severity, and response to treatment. Nevertheless, data are scarce in low- and middle-income countries. Therefore, we aimed to compare clinical manifestations; outcomes for therapy with oxygen, dexamethasone, and remdesivir; as well as the case fatality during …
Does biological age mediate the relationship between childhood adversity and depression? Insights from the Detroit Neighborhood Health Study
Intergenerational trauma transmission through family psychosocial factors in adult children of Rwandan survivors of the 1994 genocide against the Tutsi
Association between gene methylation and experiences of historical trauma in Alaska Native peoples
A community-engaged approach emphasizes balanced partnerships between communities and researchers. Here, this approach helps better understand embodiment of historical trauma in Alaska Native peoples. This analysis reveals links between the historical trauma response and DNA methylation. Indigenous communities have been stigmatized for public health issues instead caused by systemic inequalities, social disparities, and discrimination, and we arg…
Blood-derived deoxyribonucleic acid methylation clusters associate with adverse social exposures and endophenotypes of stress-related psychiatric illness in a trauma-exposed cohort of women
Adverse social exposures (ASEs) such as low income, low educational attainment, and childhood/adult trauma exposure are associated with variability in brain region measurements of gray matter volume (GMV), surface area (SA), and cortical thickness (CT). These CNS morphometries are associated with stress-related psychiatric illnesses and represent endophenotypes of stress-related psychiatric illness development. Epigenetic mechanisms, such as 5-me…
Income and Markers of Immunological Cellular Aging
OBJECTIVE: Socioeconomic disadvantage may contribute to poor health through immune-related biological mechanisms. We examined the associations between socioeconomic status, as measured by annual household income, and T-cell markers of aging, including the ratios of CD4 and CD8 effector cells to naïve cells (E/N ratio) and the CD4/CD8 T-cell ratio. We hypothesized that participants with a lower income would have higher E/N ratios and lower CD4/CD8…
Population Distributions of Thymic Function in Adults
The thymus is critical for mounting an effective immune response and maintaining health. However, epidemiologic studies characterizing thymic function in the population setting are lacking. Using data from 263 adults in the Detroit Neighborhood Health Study, we examined thymic function as measured by the number of signal joint T-cell receptor excision circles (sjTREC) and assessed associations with established indicators of physiological health. …
Sex Differences in the Association Between Depression, Anxiety, and Type 2 Diabetes Mellitus
BACKGROUND: Depression and anxiety have been inconsistently associated with diabetes. Sex differences in the biological and behavioral correlates of these forms of distress could partially explain these inconsistencies. We investigated sex-specific associations between depression/anxiety symptoms and diabetes in two separate samples. METHODS: The First National Health and Nutrition Examination Survey enrolled 3233 participants aged 25 to 74 years…
The Collateral Damage of Mass Incarceration
Objectives. We examined whether residence in neighborhoods with high levels of incarceration is associated with psychiatric morbidity among nonincarcerated community members. Methods. We linked zip code–linked information on neighborhood prison admissions rates to individual-level data on mental health from the Detroit Neighborhood Health Study (2008–2012), a prospective probability sample of predominantly Black individuals. Results. Controlling …
Trajectories of Posttraumatic Stress Among Urban Residents
Urban residents experience a wide range of traumatic events and are at increased risk of assaultive violence. Although previous research has examined trajectories of posttraumatic stress (PTS) through latent class growth analysis (LCGA) among persons exposed to the same index events (e.g., a natural disaster), PTS trajectories have not been documented among urban residents. The aims of this study were to conduct LGCA with a sample of trauma survi…
Characterization of human cortical gene expression in relation to glucose utilization
OBJECTIVES: Human brain development follows a unique pattern characterized by a prolonged period of postnatal growth and reorganization, and a postnatal peak in glucose utilization. The molecular processes underlying these developmental changes are poorly characterized. The objectives of this study were to determine developmental trajectories of gene expression and to examine the evolutionary history of genes differentially expressed as a functio…
Prevalence of Sexual Violence and Posttraumatic Stress Disorder in an Urban African-American Population
Epigenetic Signatures May Explain the Relationship between Socioeconomic Position and Risk of Mental Illness
Low socioeconomic position (SEP) has previously been linked to a number of negative health indicators, including poor mental health. The biologic mechanisms linking SEP and mental health remain poorly understood. Recent work suggests that social exposures influence DNA methylation in a manner salient to mental health. We conducted a pilot investigation to assess whether SEP, measured as educational attainment, modifies the association between gen…
Stress, adherence to preventive measures for reducing influenza transmission and influenza-like illness
BACKGROUND: Using data from a randomised intervention trial of facemask use and hand hygiene for reducing transmission of seasonal influenza among university students, we examined if levels of perceived stress were negatively associated with adherence to these preventive measures and incidence of influenza-like illness (ILI). METHODS: Longitudinal analyses using generalised estimating equations were examined. Perceived stress was self-reported at…
The Collateral Damage of Mass Incarceration
Objectives. We examined whether residence in neighborhoods with high levels of incarceration is associated with psychiatric morbidity among nonincarcerated community members. Methods. We linked zip code–linked information on neighborhood prison admissions rates to individual-level data on mental health from the Detroit Neighborhood Health Study (2008–2012), a prospective probability sample of predominantly Black individuals. Results. Controlling …
Trajectories of Posttraumatic Stress Among Urban Residents
Urban residents experience a wide range of traumatic events and are at increased risk of assaultive violence. Although previous research has examined trajectories of posttraumatic stress (PTS) through latent class growth analysis (LCGA) among persons exposed to the same index events (e.g., a natural disaster), PTS trajectories have not been documented among urban residents. The aims of this study were to conduct LGCA with a sample of trauma survi…
Epigenetic Signatures May Explain the Relationship between Socioeconomic Position and Risk of Mental Illness
Low socioeconomic position (SEP) has previously been linked to a number of negative health indicators, including poor mental health. The biologic mechanisms linking SEP and mental health remain poorly understood. Recent work suggests that social exposures influence DNA methylation in a manner salient to mental health. We conducted a pilot investigation to assess whether SEP, measured as educational attainment, modifies the association between gen…
Does biological age mediate the relationship between childhood adversity and depression? Insights from the Detroit Neighborhood Health Study
Intergenerational trauma transmission through family psychosocial factors in adult children of Rwandan survivors of the 1994 genocide against the Tutsi
Stress, adherence to preventive measures for reducing influenza transmission and influenza-like illness
BACKGROUND: Using data from a randomised intervention trial of facemask use and hand hygiene for reducing transmission of seasonal influenza among university students, we examined if levels of perceived stress were negatively associated with adherence to these preventive measures and incidence of influenza-like illness (ILI). METHODS: Longitudinal analyses using generalised estimating equations were examined. Perceived stress was self-reported at…
Characterization of human cortical gene expression in relation to glucose utilization
OBJECTIVES: Human brain development follows a unique pattern characterized by a prolonged period of postnatal growth and reorganization, and a postnatal peak in glucose utilization. The molecular processes underlying these developmental changes are poorly characterized. The objectives of this study were to determine developmental trajectories of gene expression and to examine the evolutionary history of genes differentially expressed as a functio…
Prevalence of Sexual Violence and Posttraumatic Stress Disorder in an Urban African-American Population
Epigenetic Signatures May Explain the Relationship between Socioeconomic Position and Risk of Mental Illness
Low socioeconomic position (SEP) has previously been linked to a number of negative health indicators, including poor mental health. The biologic mechanisms linking SEP and mental health remain poorly understood. Recent work suggests that social exposures influence DNA methylation in a manner salient to mental health. We conducted a pilot investigation to assess whether SEP, measured as educational attainment, modifies the association between gen…
Trajectories of Posttraumatic Stress Among Urban Residents
Urban residents experience a wide range of traumatic events and are at increased risk of assaultive violence. Although previous research has examined trajectories of posttraumatic stress (PTS) through latent class growth analysis (LCGA) among persons exposed to the same index events (e.g., a natural disaster), PTS trajectories have not been documented among urban residents. The aims of this study were to conduct LGCA with a sample of trauma survi…
Sex Differences in the Association Between Depression, Anxiety, and Type 2 Diabetes Mellitus
BACKGROUND: Depression and anxiety have been inconsistently associated with diabetes. Sex differences in the biological and behavioral correlates of these forms of distress could partially explain these inconsistencies. We investigated sex-specific associations between depression/anxiety symptoms and diabetes in two separate samples. METHODS: The First National Health and Nutrition Examination Survey enrolled 3233 participants aged 25 to 74 years…
The Collateral Damage of Mass Incarceration
Objectives. We examined whether residence in neighborhoods with high levels of incarceration is associated with psychiatric morbidity among nonincarcerated community members. Methods. We linked zip code–linked information on neighborhood prison admissions rates to individual-level data on mental health from the Detroit Neighborhood Health Study (2008–2012), a prospective probability sample of predominantly Black individuals. Results. Controlling …
Income and Markers of Immunological Cellular Aging
OBJECTIVE: Socioeconomic disadvantage may contribute to poor health through immune-related biological mechanisms. We examined the associations between socioeconomic status, as measured by annual household income, and T-cell markers of aging, including the ratios of CD4 and CD8 effector cells to naïve cells (E/N ratio) and the CD4/CD8 T-cell ratio. We hypothesized that participants with a lower income would have higher E/N ratios and lower CD4/CD8…
Population Distributions of Thymic Function in Adults
The thymus is critical for mounting an effective immune response and maintaining health. However, epidemiologic studies characterizing thymic function in the population setting are lacking. Using data from 263 adults in the Detroit Neighborhood Health Study, we examined thymic function as measured by the number of signal joint T-cell receptor excision circles (sjTREC) and assessed associations with established indicators of physiological health. …
Blood-derived deoxyribonucleic acid methylation clusters associate with adverse social exposures and endophenotypes of stress-related psychiatric illness in a trauma-exposed cohort of women
Adverse social exposures (ASEs) such as low income, low educational attainment, and childhood/adult trauma exposure are associated with variability in brain region measurements of gray matter volume (GMV), surface area (SA), and cortical thickness (CT). These CNS morphometries are associated with stress-related psychiatric illnesses and represent endophenotypes of stress-related psychiatric illness development. Epigenetic mechanisms, such as 5-me…
Association between gene methylation and experiences of historical trauma in Alaska Native peoples
A community-engaged approach emphasizes balanced partnerships between communities and researchers. Here, this approach helps better understand embodiment of historical trauma in Alaska Native peoples. This analysis reveals links between the historical trauma response and DNA methylation. Indigenous communities have been stigmatized for public health issues instead caused by systemic inequalities, social disparities, and discrimination, and we arg…
Clinical characterisation, treatment outcomes, and case fatality risk of patients with different Sars-CoV-2 variants in Bangladesh
Background: Bangladesh underwent four waves of the coronavirus disease 2019 (COVID-19) pandemic. Analysing them is essential for understanding changes in viral behaviour, disease patterns, severity, and response to treatment. Nevertheless, data are scarce in low- and middle-income countries. Therefore, we aimed to compare clinical manifestations; outcomes for therapy with oxygen, dexamethasone, and remdesivir; as well as the case fatality during …
Does biological age mediate the relationship between childhood adversity and depression? Insights from the Detroit Neighborhood Health Study
Intergenerational trauma transmission through family psychosocial factors in adult children of Rwandan survivors of the 1994 genocide against the Tutsi
Medicine (13 works) · Psychiatry (8 works) · Clinical Psychology (7 works) · Environmental health (7 works) · Psychology (7 works) · Internal Medicine (6 works) · Population (6 works) · Biology (5 works) · Child Abuse and Trauma (4 works) · Clinical Psychology (4 works)