Olga V Zubatkina
Biographic Data
| ID | 3813320 |
|---|---|
| NAME | Olga V Zubatkina |
| GIVEN NAMES | Olga V |
| FAMILY NAME | Zubatkina |
| SIGNATURE | ZUBATKINA O V |
| AFFILIATIONS | Northern (Arctic) Federal University |
| ORCID | 0000-0002-5039-2220 |
| VERIFIED | Yes |
| TOTAL WORKS | 5 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 5 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2015 |
| LATEST PUBLICATION YEAR | 2023 |
| H-INDEX | 0 |
Intracellular level of HIF-1α as an indicator of the delayed impact of Covid-19 on peripheral blood lymphocytes metabolism
BACKGROUND: COVID-19 infection triggers metabolic alterations that are crucial for both the replication of SARS-CoV-2 and the regulation of the immune response. HIF-1, which is one of the effectors in the PI3K/Akt/mTOR signal transmission pathway, promotes the reprogramming of metabolism by enhancing aerobic glycolysis.AIM: To assess whether the intracellular level of HIF-1 can reflect changes in the metabolism of peripheral blood lymphocytes aft…
Assessment of metabolic activity and energy supply of peripheral blood lymphocytes
BACKGROUND: T-cells have the capability to change their metabolism in response to activation signals. Resting T-cells primarily use the oxidation of higher fatty acids and oxidative phosphorylation in mitochondria for their energy needs, whereas activated T-cells switch to aerobic glycolysis and glutaminolysis, using glucose, and glutamine as substrates, respectively. AIM: To determine the metabolic activity and energy supply of peripheral blood …
Concentrations of Peripheral Blood Lymphocytes Intracellular Metabolic Regulators in Residents of the European North of Russia
Introduction: Metabolic processes controlled by cellular signaling mechanisms influence differentiation, proliferation, functional activity, and phenotypic stability of T cells. Hypoxia-inducible factor 1 (HIF-1) is a positive regulator of glycolysis. HIF-1 can be activated by an oxygen-independent pathway through the transcriptional activator STAT3. Sirtuin-3 (SIRT3) regulates the activity of the mitochondrial processes. Aim: To determine the ch…
Peripheral Blood Lymphocytes Adenosine Triphosphate Availability Among the Residents of the Northern European Russia
Metabolic pathways participating in adenosine triphosphate (ATP) synthesis play an important role in lymphocytes normal development and functioning. Energetic metabolism has an influence on differentiation, proliferation and fate of lymphocytes. The aim of the study is to define ATP availability of peripheral blood lymphocytes and the level of mitochondrial metabolism regulator sirtuin 3 (SIRT3) in healthy northerners. Methods. 106 volunteers, ha…
Significance of Leptin Level in Assessment of Adaptive Immunity
Adipokine leptin is produced by the adipose tissue in quantities directly proportional to its mass. It is well known as a regulator of energy exchange, which provides control of energy consumption and expenditures. New information becomes available about its participation in control of some other physiological functions including functioning of immune competent cells. We have determined parameters of the immune status and concentration of leptin …
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Significance of Leptin Level in Assessment of Adaptive Immunity
Adipokine leptin is produced by the adipose tissue in quantities directly proportional to its mass. It is well known as a regulator of energy exchange, which provides control of energy consumption and expenditures. New information becomes available about its participation in control of some other physiological functions including functioning of immune competent cells. We have determined parameters of the immune status and concentration of leptin …
Peripheral Blood Lymphocytes Adenosine Triphosphate Availability Among the Residents of the Northern European Russia
Metabolic pathways participating in adenosine triphosphate (ATP) synthesis play an important role in lymphocytes normal development and functioning. Energetic metabolism has an influence on differentiation, proliferation and fate of lymphocytes. The aim of the study is to define ATP availability of peripheral blood lymphocytes and the level of mitochondrial metabolism regulator sirtuin 3 (SIRT3) in healthy northerners. Methods. 106 volunteers, ha…
Concentrations of Peripheral Blood Lymphocytes Intracellular Metabolic Regulators in Residents of the European North of Russia
Introduction: Metabolic processes controlled by cellular signaling mechanisms influence differentiation, proliferation, functional activity, and phenotypic stability of T cells. Hypoxia-inducible factor 1 (HIF-1) is a positive regulator of glycolysis. HIF-1 can be activated by an oxygen-independent pathway through the transcriptional activator STAT3. Sirtuin-3 (SIRT3) regulates the activity of the mitochondrial processes. Aim: To determine the ch…
Assessment of metabolic activity and energy supply of peripheral blood lymphocytes
BACKGROUND: T-cells have the capability to change their metabolism in response to activation signals. Resting T-cells primarily use the oxidation of higher fatty acids and oxidative phosphorylation in mitochondria for their energy needs, whereas activated T-cells switch to aerobic glycolysis and glutaminolysis, using glucose, and glutamine as substrates, respectively. AIM: To determine the metabolic activity and energy supply of peripheral blood …
Intracellular level of HIF-1α as an indicator of the delayed impact of Covid-19 on peripheral blood lymphocytes metabolism
BACKGROUND: COVID-19 infection triggers metabolic alterations that are crucial for both the replication of SARS-CoV-2 and the regulation of the immune response. HIF-1, which is one of the effectors in the PI3K/Akt/mTOR signal transmission pathway, promotes the reprogramming of metabolism by enhancing aerobic glycolysis.AIM: To assess whether the intracellular level of HIF-1 can reflect changes in the metabolism of peripheral blood lymphocytes aft…
Biology (5 works) · Immunology (5 works) · Biochemistry (4 works) · CD8 (4 works) · Endocrinology (4 works) · Internal Medicine (4 works) · Medicine (4 works) · Cancer, Hypoxia, and Metabolism (3 works) · Chemistry (3 works) · Immune system (3 works)