James J Lee
Biographic Data
| ID | 3823027 |
|---|---|
| NAME | James J Lee |
| GIVEN NAMES | James J |
| FAMILY NAME | Lee |
| SIGNATURE | LEE J J |
| AFFILIATIONS | University of Minnesota |
| ORCID | 0000-0001-6547-5128 |
| VERIFIED | Yes |
| TOTAL WORKS | 15 |
| TOTAL CITATIONS | 56 |
| AUTHOR COUNT | 15 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2008 |
| LATEST PUBLICATION YEAR | 2025 |
| H-INDEX | 2 |
The freedom to believe in free will: Evidence from an adoption study against the first law of behavioral genetics
Philosophers and psychologists alike have long debated the etiology of beliefs about human agency. Recently, empirical investigations have shown that lay beliefs about free will and determinism represent stable and important individual differences. Despite a perennial interest in the sources of agentic belief, genetic and environmental influences on such beliefs have never been studied. We administered a battery of items assessing these beliefs t…
Associations between common genetic variants and income provide insights about the socio-economic health gradient
We conducted a genome-wide association study on income among individuals of European descent ( N = 668,288) to investigate the relationship between socio-economic status and health disparities. We identified 162 genomic loci associated with a common genetic factor underlying various income measures, all with small effect sizes (the Income Factor). Our polygenic index captures 1–5% of income variance, with only one fourth due to direct genetic eff…
Defining diagnostic uncertainty as a discourse type: A transdisciplinary approach to analysing clinical narratives of Electronic Health Records
Diagnostic uncertainty is prevalent throughout medicine and significantly impacts patient care, especially when it goes unrecognized. However, we lack a reliable clinical means of identifying uncertainty. This study evaluates the narrative discourse within clinical notes in the Electronic Health Record as a means of identifying diagnostic uncertainty. Recognizing that discourse producers use language ‘semi-automatically’ (Partington et al. 2013),…
The association between saving disposition and financial distress: A genetically informed approach
Educational Attainment and Intergenerational Mobility: A Polygenic Score Analysis
We extend a standard model of parental investment and intergenerational mobility to include a fully specified genetic analysis of skill transmission. The model’s predictions differ substantially from the standard model’s. The coefficient of intergenerational income elasticity (IGE) may be larger than that in the standard model and depends on the distribution of the genotype. The distribution of genetic endowments may be stratified according to in…
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half th…
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify…
Irish Nationalists in America: The Politics of Exile, 1798–1998, by David Brundage
The history of Irish nationalists in the USA from the Irish rebellion of 1798, where a conservative estimate of the rebel dead is about 30,000, in a total population of possibly 5 million, or perhaps 1.5 million in the affected areas, to the Good Friday Agreement of 1998, which brought an end to nearly thirty years of ‘Troubles’ between Irish nationalists and Ulster unionists within Northern Ireland, poses a particular challenge. That challenge a…
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Genome-wide association study identifies 74 loci associated with educational attainment
Second-generation PLINK: Rising to the challenge of larger and richer datasets
The Fourth Law of Behavior Genetics
Behavior genetics is the study of the relationship between genetic variation and psychological traits. Turkheimer (2000) proposed “Three Laws of Behavior Genetics” based on empirical regularities observed in studies of twins and other kinships. On the basis of molecular studies that have measured DNA variation directly, we propose a Fourth Law of Behavior Genetics: “A typical human behavioral trait is associated with very many genetic variants, e…
Why It Is Hard to Find Genes Associated With Social Science Traits: Theoretical and Empirical Considerations
Objectives. We explain why traits of interest to behavioral scientists may have a genetic architecture featuring hundreds or thousands of loci with tiny individual effects rather than a few with large effects and why such an architecture makes it difficult to find robust associations between traits and genes. Methods. We conducted a genome-wide association study at 2 sites, Harvard University and Union College, measuring more than 100 physical an…
Rationales for indirect speech: The theory of the strategic speaker
Speakers often do not state requests directly but employ innuendos such as Would you like to see my etchings?Though such indirectness seems puzzlingly inefficient, it can be explained by a theory of the Strategic Speaker, who seeks plausible deniability when he is uncertain of whether the hearer is cooperative or antagonistic.A paradigm case is bribing a policeman who may be corrupt or honest: a veiled bribe may be accepted by the former and igno…
The logic of indirect speech
When people speak, they often insinuate their intent indirectly rather than stating it as a bald proposition. Examples include sexual come-ons, veiled threats, polite requests, and concealed bribes. We propose a three-part theory of indirect speech, based on the idea that human communication involves a mixture of cooperation and conflict. First, indirect requests allow for plausible deniability, in which a cooperative listener can accept the requ…
Rationales for indirect speech: The theory of the strategic speaker
Speakers often do not state requests directly but employ innuendos such as Would you like to see my etchings?Though such indirectness seems puzzlingly inefficient, it can be explained by a theory of the Strategic Speaker, who seeks plausible deniability when he is uncertain of whether the hearer is cooperative or antagonistic.A paradigm case is bribing a policeman who may be corrupt or honest: a veiled bribe may be accepted by the former and igno…
Associations between common genetic variants and income provide insights about the socio-economic health gradient
We conducted a genome-wide association study on income among individuals of European descent ( N = 668,288) to investigate the relationship between socio-economic status and health disparities. We identified 162 genomic loci associated with a common genetic factor underlying various income measures, all with small effect sizes (the Income Factor). Our polygenic index captures 1–5% of income variance, with only one fourth due to direct genetic eff…
The association between saving disposition and financial distress: A genetically informed approach
Educational Attainment and Intergenerational Mobility: A Polygenic Score Analysis
We extend a standard model of parental investment and intergenerational mobility to include a fully specified genetic analysis of skill transmission. The model’s predictions differ substantially from the standard model’s. The coefficient of intergenerational income elasticity (IGE) may be larger than that in the standard model and depends on the distribution of the genotype. The distribution of genetic endowments may be stratified according to in…
Why It Is Hard to Find Genes Associated With Social Science Traits: Theoretical and Empirical Considerations
Objectives. We explain why traits of interest to behavioral scientists may have a genetic architecture featuring hundreds or thousands of loci with tiny individual effects rather than a few with large effects and why such an architecture makes it difficult to find robust associations between traits and genes. Methods. We conducted a genome-wide association study at 2 sites, Harvard University and Union College, measuring more than 100 physical an…
The logic of indirect speech
When people speak, they often insinuate their intent indirectly rather than stating it as a bald proposition. Examples include sexual come-ons, veiled threats, polite requests, and concealed bribes. We propose a three-part theory of indirect speech, based on the idea that human communication involves a mixture of cooperation and conflict. First, indirect requests allow for plausible deniability, in which a cooperative listener can accept the requ…
Rationales for indirect speech: The theory of the strategic speaker
Speakers often do not state requests directly but employ innuendos such as Would you like to see my etchings?Though such indirectness seems puzzlingly inefficient, it can be explained by a theory of the Strategic Speaker, who seeks plausible deniability when he is uncertain of whether the hearer is cooperative or antagonistic.A paradigm case is bribing a policeman who may be corrupt or honest: a veiled bribe may be accepted by the former and igno…
Why It Is Hard to Find Genes Associated With Social Science Traits: Theoretical and Empirical Considerations
Objectives. We explain why traits of interest to behavioral scientists may have a genetic architecture featuring hundreds or thousands of loci with tiny individual effects rather than a few with large effects and why such an architecture makes it difficult to find robust associations between traits and genes. Methods. We conducted a genome-wide association study at 2 sites, Harvard University and Union College, measuring more than 100 physical an…
Second-generation PLINK: Rising to the challenge of larger and richer datasets
The Fourth Law of Behavior Genetics
Behavior genetics is the study of the relationship between genetic variation and psychological traits. Turkheimer (2000) proposed “Three Laws of Behavior Genetics” based on empirical regularities observed in studies of twins and other kinships. On the basis of molecular studies that have measured DNA variation directly, we propose a Fourth Law of Behavior Genetics: “A typical human behavioral trait is associated with very many genetic variants, e…
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Genome-wide association study identifies 74 loci associated with educational attainment
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify…
Irish Nationalists in America: The Politics of Exile, 1798–1998, by David Brundage
The history of Irish nationalists in the USA from the Irish rebellion of 1798, where a conservative estimate of the rebel dead is about 30,000, in a total population of possibly 5 million, or perhaps 1.5 million in the affected areas, to the Good Friday Agreement of 1998, which brought an end to nearly thirty years of ‘Troubles’ between Irish nationalists and Ulster unionists within Northern Ireland, poses a particular challenge. That challenge a…
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half th…
The association between saving disposition and financial distress: A genetically informed approach
Educational Attainment and Intergenerational Mobility: A Polygenic Score Analysis
We extend a standard model of parental investment and intergenerational mobility to include a fully specified genetic analysis of skill transmission. The model’s predictions differ substantially from the standard model’s. The coefficient of intergenerational income elasticity (IGE) may be larger than that in the standard model and depends on the distribution of the genotype. The distribution of genetic endowments may be stratified according to in…
Defining diagnostic uncertainty as a discourse type: A transdisciplinary approach to analysing clinical narratives of Electronic Health Records
Diagnostic uncertainty is prevalent throughout medicine and significantly impacts patient care, especially when it goes unrecognized. However, we lack a reliable clinical means of identifying uncertainty. This study evaluates the narrative discourse within clinical notes in the Electronic Health Record as a means of identifying diagnostic uncertainty. Recognizing that discourse producers use language ‘semi-automatically’ (Partington et al. 2013),…
The freedom to believe in free will: Evidence from an adoption study against the first law of behavioral genetics
Philosophers and psychologists alike have long debated the etiology of beliefs about human agency. Recently, empirical investigations have shown that lay beliefs about free will and determinism represent stable and important individual differences. Despite a perennial interest in the sources of agentic belief, genetic and environmental influences on such beliefs have never been studied. We administered a battery of items assessing these beliefs t…
Associations between common genetic variants and income provide insights about the socio-economic health gradient
We conducted a genome-wide association study on income among individuals of European descent ( N = 668,288) to investigate the relationship between socio-economic status and health disparities. We identified 162 genomic loci associated with a common genetic factor underlying various income measures, all with small effect sizes (the Income Factor). Our polygenic index captures 1–5% of income variance, with only one fourth due to direct genetic eff…
Biology (9 works) · Genetic Associations and Epidemiology (8 works) · Genetics (8 works) · Gene (6 works) · Genome-wide association study (6 works) · Psychology (6 works) · Single-nucleotide polymorphism (5 works) · Birth, Development, and Health (4 works) · Computer Science (4 works) · Genetic association (4 works)