Leslie Lenert
Biographic Data
| ID | 5538371 |
|---|---|
| NAME | Leslie Lenert |
| GIVEN NAMES | Leslie |
| FAMILY NAME | Lenert |
| SIGNATURE | LENERT L |
| AFFILIATIONS | VA San Diego Healthcare System |
| ORCID | 0000-0002-9680-5094 |
| VERIFIED | Yes |
| TOTAL WORKS | 16 |
| TOTAL CITATIONS | 6 |
| AUTHOR COUNT | 16 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1997 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 1 |
Application of intersectionality framework and area-level indicators in machine learning analysis of depression disparities in all of us research program data
Depression is a complex mental health disorder influenced by various social determinants of health (SDOH) at individual and community levels. Area-level indicators and the intersectionality framework, which considers overlapping personal identities, are used in this paper to get a nuanced picture of depression disparities. This cross-sectional study uses electronic health records data from the All of Us research network. Our study cohort includes…
Using large language models for extracting stressful life events to assess their impact on preventive colon cancer screening adherence
Our findings suggest that stressful life events might have a counterintuitive impact on screening, with some events, such as bereavement, were associated with increased screening. Future work should be focused on validating the research findings using data from other health institutions. In addition, expanding the list of stressful life events by including a validated scale of stressful life events for patients from historically marginalized grou…
Lenert and Sundwall Respond
We were glad to learn that Kass-Hout et al. also believe that cloud-based Platform as a Service (PaaS) technology is a potential solution to the crisis created by inadequate public health funding in the Meaningful Use (MUse) program. Centers for Disease Control and Prevention (CDC) leadership is needed to respond to this crisis. In their letter, Kass-Hout et al. go on to quote from a First Look version of our article that appeared on the Journal …
Public Health Surveillance and Meaningful Use Regulations
The Health Information Technology for Economic and Clinical Health Act is intended to enhance reimbursement of health care providers for meaningful use of electronic health records systems. This presents both opportunities and challenges for public health departments. To earn incentive payments, clinical providers must exchange specified types of data with the public health system, such as immunization and syndromic surveillance data and notifiab…
Utilities For Prostate Cancer Health States in Men Aged 60 and Older
PURPOSE: We sought to measure utilities for prostate cancer health states in older men. METHODS: A total of 162 men aged 60 years or older (52% of whom had been diagnosed with prostate cancer) provided standard gamble utilities for 19 health states associated with prostate cancer or its treatment using an interactive, computer-based utility assessment program. Demographics and experience with specific health states were examined as predictors of …
Discrete State Analysis for Interpretation of Data From Clinical Trials
OBJECTIVE: The objective of this study was to demonstrate a multivariate health state approach to analyzing complex disease data that allows projection of long-term outcomes using clustering, Markov modeling, and preference weights. SUBJECTS: We studied patients hospitalized 30 to 364 days with refractory schizophrenia at 15 Veterans Affairs medical centers. STUDY DESIGN: We conducted a randomized clinical trial comparing clozapine, an atypical a…
Use of Willingness to Pay to Study Values for Pharmacotherapies for Migraine Headache
BACKGROUND: There is a wide range of therapeutic options for migraine headaches, yet little is known about how patients value different treatment alternatives nor how to tailor treatments to patients' preferences. OBJECTIVE: Assess patients' preferences for outcomes of treatment of migraine headache based on their marginal willingness to pay (WTP) for treatment attributes. MATERIALS AND METHODS: In an Internet-based study, we used computer softwa…
Can Utility-Weighted Health-Related Quality-of-Life Estimates Capture Health Effects of Quality Improvement for Depression
BACKGROUND: Utility methods that are responsive to changes in desirable outcomes are needed for cost-effectiveness (CE) analyses and to help in decisions about resource allocation. OBJECTIVES: Evaluated is the responsiveness of different methods that assign utility weights to subsets of SF-36 items to average improvements in health resulting from quality improvement (QI) interventions for depression. DESIGN: A group level, randomized, control tri…
The reliability and internal consistency of an Internet-capable computer program for measuring utilities
Validity and Interpretation of Preference-Based Measures of Health-Related Quality of Life
Utilities are numeric measurements that reflect an individual's beliefs about the desirableness of a health condition, willingness to take risks to gain health benefits, and preferences for time. This report discusses the approaches to assess and compare the validity of methods used to assign utilities for cost-utility analysis. Threats to validity include construct underrepresentation and construct-irrelevant variance. Construct underrepresentat…
Differences in Health Values Among Patients, Family Members, and Providers for Outcomes in Schizophrenia
OBJECTIVE: The objectives of this study were to determine whether there are important differences in how patients, family members, and health care providers (HCPs) value health outcomes in schizophrenia and to assess the degree to which such differences, if they exist, could adversely affect clinical and policy decision making. METHODS: Participants viewed videotaped depictions of simulated patients with mild and moderate symptoms of schizophreni…
Quality Enhancement Research Initiative for Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome
The Veterans Health Administration (VHA) sees ≈17,000 human immunodeficiency virus (HIV)-infected patients each year, which makes it the largest provider of HIV care in the United States. HIV causes chronic progressive disease that leads to early death. Newer combination antiretroviral treatments ar
Estimation of Utilities for the Effects of Depression From the SF-12
BACKGROUND: Utilities for health conditions, including major depressive disorder, have a theoretical relationship to health-related quality of life (HRQOL). Because of the complexity of utility measurement and the existence of large numbers of completed studies with HRQOL data but not utility data, it would be desirable to be able to estimate utilities from measurements of HRQOL. OBJECTIVE: The objective of this study was to estimate utility for …
Feasibility of quality-of-life research on the Internet
Associations Between Health Status and Utilities Implications for Policy
BACKGROUND: If shape of a person's utility function is associated with his health status, as is predicted by Prospect Theory, the use of utilities from the healthy could result in 'de facto' discrimination against the sick. OBJECTIVES: To determine if patients' utilities for hypothetical states and for their current health were associated with their health status. DESIGN: A cross-sectional study of the health and values of patients with depressiv…
Measurement of the Validity of Utility Elicitations Performed by Computerized Interview
OBJECTIVES: The authors evaluate a measure of the validity of utility elicitations and study the potential effects of invalid elicitations on population utility values. METHODS: The authors used a computerized survey to describe and measure preferences for three common side-effects of anti-psychotic drugs (tardive dyskinesia [TD], akathesia [AKA], pseudo-parkinsonism). The authors compared the validity of elicitations in 41 healthy volunteers to …
Public Health Surveillance and Meaningful Use Regulations
The Health Information Technology for Economic and Clinical Health Act is intended to enhance reimbursement of health care providers for meaningful use of electronic health records systems. This presents both opportunities and challenges for public health departments. To earn incentive payments, clinical providers must exchange specified types of data with the public health system, such as immunization and syndromic surveillance data and notifiab…
Measurement of the Validity of Utility Elicitations Performed by Computerized Interview
OBJECTIVES: The authors evaluate a measure of the validity of utility elicitations and study the potential effects of invalid elicitations on population utility values. METHODS: The authors used a computerized survey to describe and measure preferences for three common side-effects of anti-psychotic drugs (tardive dyskinesia [TD], akathesia [AKA], pseudo-parkinsonism). The authors compared the validity of elicitations in 41 healthy volunteers to …
Feasibility of quality-of-life research on the Internet
Associations Between Health Status and Utilities Implications for Policy
BACKGROUND: If shape of a person's utility function is associated with his health status, as is predicted by Prospect Theory, the use of utilities from the healthy could result in 'de facto' discrimination against the sick. OBJECTIVES: To determine if patients' utilities for hypothetical states and for their current health were associated with their health status. DESIGN: A cross-sectional study of the health and values of patients with depressiv…
The reliability and internal consistency of an Internet-capable computer program for measuring utilities
Validity and Interpretation of Preference-Based Measures of Health-Related Quality of Life
Utilities are numeric measurements that reflect an individual's beliefs about the desirableness of a health condition, willingness to take risks to gain health benefits, and preferences for time. This report discusses the approaches to assess and compare the validity of methods used to assign utilities for cost-utility analysis. Threats to validity include construct underrepresentation and construct-irrelevant variance. Construct underrepresentat…
Differences in Health Values Among Patients, Family Members, and Providers for Outcomes in Schizophrenia
OBJECTIVE: The objectives of this study were to determine whether there are important differences in how patients, family members, and health care providers (HCPs) value health outcomes in schizophrenia and to assess the degree to which such differences, if they exist, could adversely affect clinical and policy decision making. METHODS: Participants viewed videotaped depictions of simulated patients with mild and moderate symptoms of schizophreni…
Quality Enhancement Research Initiative for Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome
The Veterans Health Administration (VHA) sees ≈17,000 human immunodeficiency virus (HIV)-infected patients each year, which makes it the largest provider of HIV care in the United States. HIV causes chronic progressive disease that leads to early death. Newer combination antiretroviral treatments ar
Estimation of Utilities for the Effects of Depression From the SF-12
BACKGROUND: Utilities for health conditions, including major depressive disorder, have a theoretical relationship to health-related quality of life (HRQOL). Because of the complexity of utility measurement and the existence of large numbers of completed studies with HRQOL data but not utility data, it would be desirable to be able to estimate utilities from measurements of HRQOL. OBJECTIVE: The objective of this study was to estimate utility for …
Can Utility-Weighted Health-Related Quality-of-Life Estimates Capture Health Effects of Quality Improvement for Depression
BACKGROUND: Utility methods that are responsive to changes in desirable outcomes are needed for cost-effectiveness (CE) analyses and to help in decisions about resource allocation. OBJECTIVES: Evaluated is the responsiveness of different methods that assign utility weights to subsets of SF-36 items to average improvements in health resulting from quality improvement (QI) interventions for depression. DESIGN: A group level, randomized, control tri…
Use of Willingness to Pay to Study Values for Pharmacotherapies for Migraine Headache
BACKGROUND: There is a wide range of therapeutic options for migraine headaches, yet little is known about how patients value different treatment alternatives nor how to tailor treatments to patients' preferences. OBJECTIVE: Assess patients' preferences for outcomes of treatment of migraine headache based on their marginal willingness to pay (WTP) for treatment attributes. MATERIALS AND METHODS: In an Internet-based study, we used computer softwa…
Discrete State Analysis for Interpretation of Data From Clinical Trials
OBJECTIVE: The objective of this study was to demonstrate a multivariate health state approach to analyzing complex disease data that allows projection of long-term outcomes using clustering, Markov modeling, and preference weights. SUBJECTS: We studied patients hospitalized 30 to 364 days with refractory schizophrenia at 15 Veterans Affairs medical centers. STUDY DESIGN: We conducted a randomized clinical trial comparing clozapine, an atypical a…
Utilities For Prostate Cancer Health States in Men Aged 60 and Older
PURPOSE: We sought to measure utilities for prostate cancer health states in older men. METHODS: A total of 162 men aged 60 years or older (52% of whom had been diagnosed with prostate cancer) provided standard gamble utilities for 19 health states associated with prostate cancer or its treatment using an interactive, computer-based utility assessment program. Demographics and experience with specific health states were examined as predictors of …
Lenert and Sundwall Respond
We were glad to learn that Kass-Hout et al. also believe that cloud-based Platform as a Service (PaaS) technology is a potential solution to the crisis created by inadequate public health funding in the Meaningful Use (MUse) program. Centers for Disease Control and Prevention (CDC) leadership is needed to respond to this crisis. In their letter, Kass-Hout et al. go on to quote from a First Look version of our article that appeared on the Journal …
Public Health Surveillance and Meaningful Use Regulations
The Health Information Technology for Economic and Clinical Health Act is intended to enhance reimbursement of health care providers for meaningful use of electronic health records systems. This presents both opportunities and challenges for public health departments. To earn incentive payments, clinical providers must exchange specified types of data with the public health system, such as immunization and syndromic surveillance data and notifiab…
Using large language models for extracting stressful life events to assess their impact on preventive colon cancer screening adherence
Our findings suggest that stressful life events might have a counterintuitive impact on screening, with some events, such as bereavement, were associated with increased screening. Future work should be focused on validating the research findings using data from other health institutions. In addition, expanding the list of stressful life events by including a validated scale of stressful life events for patients from historically marginalized grou…
Application of intersectionality framework and area-level indicators in machine learning analysis of depression disparities in all of us research program data
Depression is a complex mental health disorder influenced by various social determinants of health (SDOH) at individual and community levels. Area-level indicators and the intersectionality framework, which considers overlapping personal identities, are used in this paper to get a nuanced picture of depression disparities. This cross-sectional study uses electronic health records data from the All of Us research network. Our study cohort includes…
Medicine (14 works) · Health Systems, Economic Evaluations, Quality of Life (8 works) · Internal Medicine (8 works) · Health care (6 works) · Internal Medicine (6 works) · Psychiatry (6 works) · Psychology (5 works) · Disease (4 works) · Economic and Environmental Valuation (4 works) · Nursing (4 works)