Simon E Fisher
Biographic Data
| ID | 5628909 |
|---|---|
| NAME | Simon E Fisher |
| GIVEN NAMES | Simon E |
| FAMILY NAME | Fisher |
| SIGNATURE | FISHER S E |
| AFFILIATIONS | Radboud University Nijmegen |
| ORCID | 0000-0002-3132-1996 |
| VERIFIED | Yes |
| TOTAL WORKS | 12 |
| TOTAL CITATIONS | 7 |
| WORKS AS AUTHOR | 12 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 1987 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 2 |
Developing language in a developing body
Background Mastering gross motor abilities in early infancy and culturally defined actions (e.g. self‐care routines) in late infancy can initiate cascading developmental changes that affect language learning. Here, we adopt a genetic perspective to investigate underlying processes, implicating either shared or “gateway” mechanisms, where the latter enable children to interact with their environment. Methods Selecting heritable traits ( h 2 , heri…
The shared genetic architecture and evolution of human language and musical rhythm
This study aimed to test theoretical predictions over biological underpinnings of previously documented phenotypic correlations between human language-related and musical rhythm traits. Here, after identifying significant genetic correlations between rhythm, dyslexia and various language-related traits, we adapted multivariate methods to capture genetic signals common to genome-wide association studies of rhythm (N = 606,825) and dyslexia (N = 1,…
Language and reading impairments are associated with increased prevalence of non-right-handedness
Handedness has been studied for association with language-related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non-right-handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex-matched controls identified from 10 distinct cohorts (age range 6–…
Lessons From the First Decade of the Native American Summer Research Internship at the University of Utah
PROBLEM: American Indian/Alaska Native (AI/AN) populations are facing multiple health crises, including limited access to care, high rates of chronic disease, and early mortality that is far worse than other underrepresented minorities in the United States. According to the Association of American Indian Physicians, AI/AN people represent 2.0% of the U.S. population but only 0.2% of medical students and 0.1% of full-time faculty at MD-granting in…
Analysis of structural brain asymmetries in attention‐deficit/hyperactivity disorder in 39 datasets
OBJECTIVE: Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium. METHODS: We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 una…
The developmental origins of genetic factors influencing language and literacy
BACKGROUND: The heritability of language and literacy skills increases from early-childhood to adolescence. The underlying mechanisms are little understood and may involve (a) the amplification of genetic influences contributing to early language abilities, and/or (b) the emergence of novel genetic factors (innovation). Here, we investigate the developmental origins of genetic factors influencing mid-childhood/early-adolescent language and litera…
The genetic architecture of structural left-right asymmetry of the human brain
Left-right hemispheric asymmetry is an important aspect of healthy brain organization for many functions including language, and it can be altered in cognitive and psychiatric disorders. No mechanism has yet been identified for establishing the human brain's left-right axis. We performed multivariate genome-wide association scanning of cortical regional surface area and thickness asymmetries, and subcortical volume asymmetries, using data from 32…
Genetics and the Language Sciences
Theories addressing the biological basis of language must be built on an appreciation of the ways that molecular and neurobiological substrates can contribute to aspects of human cognition. Here, we lay out the principles by which a genome could potentially encode the necessary information to produce a language-ready brain. We describe what genes are; how they are regulated; and how they affect the formation, function, and plasticity of neuronal …
Genetics of Language
It has long been hypothesised that the human faculty to acquire a language is in some way encoded in our genetic program. However, only recently has genetic evidence been available to begin to substantiate the presumed genetic basis of language. Here we review the first data from molecular genetic studies showing association between gene variants and language disorders (specific language impairment, speech sound disorder, developmental dyslexia),…
Molecular evolution of Foxp2, a gene involved in speech and language
A forkhead-domain gene is mutated in a severe speech and language disorder
Half‐way Demythologisation
The genetic architecture of structural left-right asymmetry of the human brain
Left-right hemispheric asymmetry is an important aspect of healthy brain organization for many functions including language, and it can be altered in cognitive and psychiatric disorders. No mechanism has yet been identified for establishing the human brain's left-right axis. We performed multivariate genome-wide association scanning of cortical regional surface area and thickness asymmetries, and subcortical volume asymmetries, using data from 32…
Genetics and the Language Sciences
Theories addressing the biological basis of language must be built on an appreciation of the ways that molecular and neurobiological substrates can contribute to aspects of human cognition. Here, we lay out the principles by which a genome could potentially encode the necessary information to produce a language-ready brain. We describe what genes are; how they are regulated; and how they affect the formation, function, and plasticity of neuronal …
Half‐way Demythologisation
A forkhead-domain gene is mutated in a severe speech and language disorder
Molecular evolution of Foxp2, a gene involved in speech and language
Genetics of Language
It has long been hypothesised that the human faculty to acquire a language is in some way encoded in our genetic program. However, only recently has genetic evidence been available to begin to substantiate the presumed genetic basis of language. Here we review the first data from molecular genetic studies showing association between gene variants and language disorders (specific language impairment, speech sound disorder, developmental dyslexia),…
Genetics and the Language Sciences
Theories addressing the biological basis of language must be built on an appreciation of the ways that molecular and neurobiological substrates can contribute to aspects of human cognition. Here, we lay out the principles by which a genome could potentially encode the necessary information to produce a language-ready brain. We describe what genes are; how they are regulated; and how they affect the formation, function, and plasticity of neuronal …
Lessons From the First Decade of the Native American Summer Research Internship at the University of Utah
PROBLEM: American Indian/Alaska Native (AI/AN) populations are facing multiple health crises, including limited access to care, high rates of chronic disease, and early mortality that is far worse than other underrepresented minorities in the United States. According to the Association of American Indian Physicians, AI/AN people represent 2.0% of the U.S. population but only 0.2% of medical students and 0.1% of full-time faculty at MD-granting in…
Analysis of structural brain asymmetries in attention‐deficit/hyperactivity disorder in 39 datasets
OBJECTIVE: Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium. METHODS: We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 una…
The developmental origins of genetic factors influencing language and literacy
BACKGROUND: The heritability of language and literacy skills increases from early-childhood to adolescence. The underlying mechanisms are little understood and may involve (a) the amplification of genetic influences contributing to early language abilities, and/or (b) the emergence of novel genetic factors (innovation). Here, we investigate the developmental origins of genetic factors influencing mid-childhood/early-adolescent language and litera…
The genetic architecture of structural left-right asymmetry of the human brain
Left-right hemispheric asymmetry is an important aspect of healthy brain organization for many functions including language, and it can be altered in cognitive and psychiatric disorders. No mechanism has yet been identified for establishing the human brain's left-right axis. We performed multivariate genome-wide association scanning of cortical regional surface area and thickness asymmetries, and subcortical volume asymmetries, using data from 32…
Language and reading impairments are associated with increased prevalence of non-right-handedness
Handedness has been studied for association with language-related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non-right-handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex-matched controls identified from 10 distinct cohorts (age range 6–…
The shared genetic architecture and evolution of human language and musical rhythm
This study aimed to test theoretical predictions over biological underpinnings of previously documented phenotypic correlations between human language-related and musical rhythm traits. Here, after identifying significant genetic correlations between rhythm, dyslexia and various language-related traits, we adapted multivariate methods to capture genetic signals common to genome-wide association studies of rhythm (N = 606,825) and dyslexia (N = 1,…
Developing language in a developing body
Background Mastering gross motor abilities in early infancy and culturally defined actions (e.g. self‐care routines) in late infancy can initiate cascading developmental changes that affect language learning. Here, we adopt a genetic perspective to investigate underlying processes, implicating either shared or “gateway” mechanisms, where the latter enable children to interact with their environment. Methods Selecting heritable traits ( h 2 , heri…
Psychology (10 works) · Biology (6 works) · Neuroscience (6 works) · Developmental psychology (5 works) · Gene (5 works) · Linguistics (5 works) · Cognitive psychology (4 works) · Genetics (4 works) · Language Development and Disorders (4 works) · Cognition (3 works)