Barbara J Sahakian
Biographic Data
| ID | 606485 |
|---|---|
| NAME | Barbara J Sahakian |
| GIVEN NAMES | Barbara J |
| FAMILY NAME | Sahakian |
| SIGNATURE | SAHAKIAN B J |
| AFFILIATIONS | University of Cambridge |
| ORCID | 0000-0001-7352-1745 |
| VERIFIED | Yes |
| TOTAL WORKS | 16 |
| TOTAL CITATIONS | 18 |
| AUTHOR COUNT | 16 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1981 |
| LATEST PUBLICATION YEAR | 2025 |
| H-INDEX | 1 |
Validation of the CILD-Q for measuring contextual linguistic diversity in Singapore
Plasma proteomic signatures of social isolation and loneliness associated with morbidity and mortality
The biology underlying the connection between social relationships and health is largely unknown. Here, leveraging data from 42,062 participants across 2,920 plasma proteins in the UK Biobank, we characterized the proteomic signatures of social isolation and loneliness through proteome-wide association study and protein co-expression network analysis. Proteins linked to these constructs were implicated in inflammation, antiviral responses and com…
The Sage Handbook of Clinical Neuropsychology
The impact of Covid-19 social isolation on aspects of emotional and social cognition
The present study aimed to examine the impact of COVID-19 social isolation upon aspects of emotional and social cognitive function. We predicted that greater impairments in emotional and social cognition would be observed in people who experienced more disruption to their usual social connectivity during COVID-19 social isolation. Healthy volunteers (N = 92) without prior mental health problems completed assessments online in their own homes duri…
Atypical action updating in a dynamic environment associated with adolescent obsessive–compulsive disorder
BACKGROUND: Computational research had determined that adults with obsessive-compulsive disorder (OCD) display heightened action updating in response to noise in the environment and neglect metacognitive information (such as confidence) when making decisions. These features are proposed to underlie patients' compulsions despite the knowledge they are irrational. Nonetheless, it is unclear whether this extends to adolescents with OCD as research i…
Hot” and “Cold” Cognition in Users of Club Drugs/Novel Psychoactive Substances
Novel psychoactive substances (NPS) are popular "club/party" drugs that first attracted attention in the UK in 2009 and remained legal until the 2016 Psychoactive Substances Act criminalized their distribution. Unlike "traditional" illicit drugs, very little is known about the influence of their analogs on neuropsychological functioning. We characterized the cognitive and emotional profile of NPS/polydrug users using the Cambridge Neuropsychologi…
Can Mobile Technology Help Prevent the Burden of Dementia in Low- and Mid-Income Countries
According to the World Health Organization (WHO), the global population aged above 60 years will double in size by 2050, with an estimated total of about 2 billion people. The increase in life expectancy, combined with unhealthy behaviors and physical inactivity (1), is linked to an increase in non-communicable diseases (NCDs). Additionally, related to aging but not yet considered to be an NCD is cognitive decline, which is an important medical c…
Haste or Speed? Alterations in the Impact of Incentive Cues on Task Performance in Remitted and Depressed Patients With Bipolar Disorder
A variety of evidence suggests that bipolar disorder is associated with disruptions of reward related processes, although the properties, and scope of these changes are not well understood. In the present study, we aimed to address this question by examining performance of patients with bipolar disorder (30 depressed bipolar; 35 euthymic bipolar) on a motivated choice reaction time task. We compared performance with a group of healthy control ind…
Moral Emotions and Social Economic Games in Paranoia
Impaired social cognitive processes are putative psychological mechanisms implicated in the formation and maintenance of paranoid beliefs. Paranoia denotes unfounded fears about the hostile intentions of others and is prevalent in a significant proportion of the general population. We investigated social cognition in healthy participants selectively recruited to have a broad occurrence of paranoid thinking ( n = 89). Participants completed a nove…
Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task
Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one …
Grand challenges in global mental health
Towards responsible use of cognitive-enhancing drugs by the healthy
Neuroethics of Cognitive Enhancement
Impaired visual discrimination learning in anorexia nervosa
Salivation and Appetite: Commentary on the Forum
Salivation and insulin secretion in response to food in non-obese men and women
Salivation and Appetite: Commentary on the Forum
Salivation and insulin secretion in response to food in non-obese men and women
Impaired visual discrimination learning in anorexia nervosa
Neuroethics of Cognitive Enhancement
Towards responsible use of cognitive-enhancing drugs by the healthy
Grand challenges in global mental health
Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task
Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one …
Haste or Speed? Alterations in the Impact of Incentive Cues on Task Performance in Remitted and Depressed Patients With Bipolar Disorder
A variety of evidence suggests that bipolar disorder is associated with disruptions of reward related processes, although the properties, and scope of these changes are not well understood. In the present study, we aimed to address this question by examining performance of patients with bipolar disorder (30 depressed bipolar; 35 euthymic bipolar) on a motivated choice reaction time task. We compared performance with a group of healthy control ind…
Moral Emotions and Social Economic Games in Paranoia
Impaired social cognitive processes are putative psychological mechanisms implicated in the formation and maintenance of paranoid beliefs. Paranoia denotes unfounded fears about the hostile intentions of others and is prevalent in a significant proportion of the general population. We investigated social cognition in healthy participants selectively recruited to have a broad occurrence of paranoid thinking ( n = 89). Participants completed a nove…
Can Mobile Technology Help Prevent the Burden of Dementia in Low- and Mid-Income Countries
According to the World Health Organization (WHO), the global population aged above 60 years will double in size by 2050, with an estimated total of about 2 billion people. The increase in life expectancy, combined with unhealthy behaviors and physical inactivity (1), is linked to an increase in non-communicable diseases (NCDs). Additionally, related to aging but not yet considered to be an NCD is cognitive decline, which is an important medical c…
Hot” and “Cold” Cognition in Users of Club Drugs/Novel Psychoactive Substances
Novel psychoactive substances (NPS) are popular "club/party" drugs that first attracted attention in the UK in 2009 and remained legal until the 2016 Psychoactive Substances Act criminalized their distribution. Unlike "traditional" illicit drugs, very little is known about the influence of their analogs on neuropsychological functioning. We characterized the cognitive and emotional profile of NPS/polydrug users using the Cambridge Neuropsychologi…
The impact of Covid-19 social isolation on aspects of emotional and social cognition
The present study aimed to examine the impact of COVID-19 social isolation upon aspects of emotional and social cognitive function. We predicted that greater impairments in emotional and social cognition would be observed in people who experienced more disruption to their usual social connectivity during COVID-19 social isolation. Healthy volunteers (N = 92) without prior mental health problems completed assessments online in their own homes duri…
Atypical action updating in a dynamic environment associated with adolescent obsessive–compulsive disorder
BACKGROUND: Computational research had determined that adults with obsessive-compulsive disorder (OCD) display heightened action updating in response to noise in the environment and neglect metacognitive information (such as confidence) when making decisions. These features are proposed to underlie patients' compulsions despite the knowledge they are irrational. Nonetheless, it is unclear whether this extends to adolescents with OCD as research i…
The Sage Handbook of Clinical Neuropsychology
Validation of the CILD-Q for measuring contextual linguistic diversity in Singapore
Plasma proteomic signatures of social isolation and loneliness associated with morbidity and mortality
The biology underlying the connection between social relationships and health is largely unknown. Here, leveraging data from 42,062 participants across 2,920 plasma proteins in the UK Biobank, we characterized the proteomic signatures of social isolation and loneliness through proteome-wide association study and protein co-expression network analysis. Proteins linked to these constructs were implicated in inflammation, antiviral responses and com…
Psychology (14 works) · Psychiatry (11 works) · Cognition (8 works) · Medicine (8 works) · Neuroscience (5 works) · Developmental psychology (4 works) · Social Psychology (4 works) · Anxiety (3 works) · Cognitive psychology (3 works) · Internal Medicine (3 works)