Devan Jaganath
Biographic Data
| ID | 6068191 |
|---|---|
| NAME | Devan Jaganath |
| GIVEN NAMES | Devan |
| FAMILY NAME | Jaganath |
| SIGNATURE | JAGANATH D |
| AFFILIATIONS | University of California, San Francisco |
| ORCID | 0000-0002-8555-5667 |
| VERIFIED | Yes |
| TOTAL WORKS | 14 |
| TOTAL CITATIONS | 10 |
| WORKS AS AUTHOR | 8 |
| WORKS AS EDITOR | 6 |
| FIRST PUBLICATION YEAR | 2011 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 2 |
Rapid diagnosis of pulmonary tuberculosis on induced sputum in children in a high burden setting for HIV and malnutrition
Microbiological diagnosis of childhood pulmonary tuberculosis can be challenging. We investigated the accuracy of Xpert MTB/RIF Ultra on the induced sputum, focused on high-risk groups (infants, malnourished children, and those living with HIV), where data is limited. Children (under 15 years) investigated for pulmonary tuberculosis at Dora Nginza Hospital, South Africa, were prospectively enrolled between January 2018 and January 2024, and follo…
Do sociodemographic factors modify the association between antenatal care utilisation and acute respiratory infection among infants in Ethiopia
Antenatal care (ANC) is vital for optimum maternal care and could provide an opportunity to prevent acute respiratory infection (ARI) in early childhood, particularly in low-resource settings; however, its impact on ARI remains underexplored. This study examined the association between ANC utilisation and ARI in Ethiopian infants, including stratified analyses by key socio-demographic factors. A total of 4,154 mother-infant pairs were analysed, u…
Computer-aided detection for radiological disease severity classification on chest radiograph in children with intra-thoracic tuberculosis
Implementation of the World Health Organization’s (WHO) recommended shorter 4-month treatment regimen for non-severe tuberculosis (TB) in children requires classification of disease severity on chest X-ray (CXR). Access to specialists for CXR interpretation is limited. We explored the use of computer-aided detection of CXR (“CAD”) to automate CXR classification of radiological disease severity. To do this, we combined three CXR datasets from chil…
The Accuracy of the Uganda National Tuberculosis and Leprosy Program diagnostic algorithm and the World Health Organisation treatment decision algorithms for childhood tuberculosis
Diagnosing childhood pulmonary tuberculosis (TB) is a challenge. This led the Uganda National Tuberculosis and Leprosy Program (NTLP) to develop a clinical treatment decision algorithm (TDA) for children. However, there is limited data on its accuracy, and how it compares to new World Health Organization (WHO) TB TDAs for children. This study aimed to evaluate and compare the accuracy of the 2017 Uganda NTLP diagnostic algorithm with the 2022 WHO…
Assessment of scattered and leakage radiation from ultra-portable X-ray systems in chest imaging
Ultraportable (UP) X-ray devices are ideal to use in community-based settings, particularly for chest X-ray (CXR) screening of tuberculosis (TB). Unfortunately, there is insufficient guidance on the radiation safety of these devices. This study aims to determine the radiation dose by UP X-ray devices to both the public and radiographers compared to international dose limits. Radiation dose measurements were performed with four UP X-ray devices th…
Evaluating the impact of decentralized testing for tuberculosis in Ghana
Poor geographical accessibility to tuberculosis (TB) diagnostic services in Ghana is a key barrier to timely diagnosis. Decentralizing molecular testing for TB could improve TB case notification among underserved populations and enhance treatment initiation while avoiding unnecessary treatments. This study aims to project the epidemiological impact of decentralized TB testing at the country level. We developed an individual-based simulation of th…
Potential impact, costs, and benefits of population-wide screening interventions for tuberculosis in Viet Nam
Population-wide screening may accelerate the decline of tuberculosis (TB) incidence, but the optimal screening algorithm and duration must weigh resource considerations. We calibrated a deterministic transmission model to TB epidemiology in Viet Nam. We simulated three population-wide screening algorithms from 2025: sputum nucleic acid amplification tests (NAAT, Xpert MTB/RIF Ultra) only; chest radiography (CXR) followed by NAAT; and CXR-only wit…
Navigating complex care pathways–healthcare workers’ perspectives on health system barriers for children with tuberculous meningitis in Cape Town, South Africa
Tuberculous meningitis (TBM) occurs when tuberculosis (TB) bacilli disseminate and seed into the meninges, triggering a severe inflammatory response that often leads to brain infarction. It is the most severe and debilitating form of childhood TB with high mortality, and children who survive TBM often suffer lifelong physical and neuro-disability resulting in emotional, social, and economic burdens for families. In the early stages the symptoms m…
Prevalence, mortality, and aetiology of paediatric shock in a tertiary hospital in Malawi
Shock is considered one of the most important mechanisms of critical illness in children. However, data on paediatric shock in sub-Saharan Africa is limited, which constrains development of effective treatment strategies. We aimed to describe the prevalence, mortality, and aetiology of paediatric shock in a tertiary hospital in Malawi. Children aged two months to 16 years presenting with shock (FEAST criteria; respiratory distress and/or impaired…
The socioeconomic burden of pediatric tuberculosis and role of child-sensitive social protection
Households face financial and social challenges prior to a child's TB diagnosis, and child-sensitive social protection support may mitigate ongoing burden
Outcomes of empiric treatment for pediatric tuberculosis, Kampala, Uganda, 2010–2015
Empiric treatment of child TB was effective and safe, but treatment success remained below the 90% target. Addressing co-morbidities and improving retention in care may reduce unfavorable outcomes
Project Hope
Objectives. We examined whether and how an HIV prevention diffusion-based intervention spread throughout participants’ online social networks and whether changes in social network ties were associated with increased HIV prevention and testing behaviors. Methods. We randomly assigned 112 primarily racial/ethnic minority men who have sex with men (MSM) to receive peer-delivered HIV (intervention) or general health (control) information over 12 week…
Harnessing Online Peer Education (Hope)
Novel methods, such as Internet-based interventions, are needed to combat the spread of HIV. While past initiatives have used the Internet to promote HIV prevention, the growing popularity, decreasing digital divide, and multi-functionality of social networking sites, such as Facebook, make this an ideal time to develop innovative ways to use online social networking sites to scale HIV prevention interventions among high-risk groups. The UCLA Har…
Performance as a Component of HIV/Aids Education
The Process and Collaboration for Empowerment and Discussion (PACED) approach redefines the goals for employing the performing arts in HIV/AIDS education. Considering the complexity of the epidemic, art can appropriately address HIV/AIDS by placing a greater emphasis on the creative process, engaging people living with HIV/AIDS, and focusing on contextual barriers to prevention and care. This approach was implemented in Ghana in 2006 in the form …
Project Hope
Objectives. We examined whether and how an HIV prevention diffusion-based intervention spread throughout participants’ online social networks and whether changes in social network ties were associated with increased HIV prevention and testing behaviors. Methods. We randomly assigned 112 primarily racial/ethnic minority men who have sex with men (MSM) to receive peer-delivered HIV (intervention) or general health (control) information over 12 week…
Performance as a Component of HIV/Aids Education
The Process and Collaboration for Empowerment and Discussion (PACED) approach redefines the goals for employing the performing arts in HIV/AIDS education. Considering the complexity of the epidemic, art can appropriately address HIV/AIDS by placing a greater emphasis on the creative process, engaging people living with HIV/AIDS, and focusing on contextual barriers to prevention and care. This approach was implemented in Ghana in 2006 in the form …
Performance as a Component of HIV/Aids Education
The Process and Collaboration for Empowerment and Discussion (PACED) approach redefines the goals for employing the performing arts in HIV/AIDS education. Considering the complexity of the epidemic, art can appropriately address HIV/AIDS by placing a greater emphasis on the creative process, engaging people living with HIV/AIDS, and focusing on contextual barriers to prevention and care. This approach was implemented in Ghana in 2006 in the form …
Harnessing Online Peer Education (Hope)
Novel methods, such as Internet-based interventions, are needed to combat the spread of HIV. While past initiatives have used the Internet to promote HIV prevention, the growing popularity, decreasing digital divide, and multi-functionality of social networking sites, such as Facebook, make this an ideal time to develop innovative ways to use online social networking sites to scale HIV prevention interventions among high-risk groups. The UCLA Har…
Project Hope
Objectives. We examined whether and how an HIV prevention diffusion-based intervention spread throughout participants’ online social networks and whether changes in social network ties were associated with increased HIV prevention and testing behaviors. Methods. We randomly assigned 112 primarily racial/ethnic minority men who have sex with men (MSM) to receive peer-delivered HIV (intervention) or general health (control) information over 12 week…
Outcomes of empiric treatment for pediatric tuberculosis, Kampala, Uganda, 2010–2015
Empiric treatment of child TB was effective and safe, but treatment success remained below the 90% target. Addressing co-morbidities and improving retention in care may reduce unfavorable outcomes
The socioeconomic burden of pediatric tuberculosis and role of child-sensitive social protection
Households face financial and social challenges prior to a child's TB diagnosis, and child-sensitive social protection support may mitigate ongoing burden
Navigating complex care pathways–healthcare workers’ perspectives on health system barriers for children with tuberculous meningitis in Cape Town, South Africa
Tuberculous meningitis (TBM) occurs when tuberculosis (TB) bacilli disseminate and seed into the meninges, triggering a severe inflammatory response that often leads to brain infarction. It is the most severe and debilitating form of childhood TB with high mortality, and children who survive TBM often suffer lifelong physical and neuro-disability resulting in emotional, social, and economic burdens for families. In the early stages the symptoms m…
Prevalence, mortality, and aetiology of paediatric shock in a tertiary hospital in Malawi
Shock is considered one of the most important mechanisms of critical illness in children. However, data on paediatric shock in sub-Saharan Africa is limited, which constrains development of effective treatment strategies. We aimed to describe the prevalence, mortality, and aetiology of paediatric shock in a tertiary hospital in Malawi. Children aged two months to 16 years presenting with shock (FEAST criteria; respiratory distress and/or impaired…
The Accuracy of the Uganda National Tuberculosis and Leprosy Program diagnostic algorithm and the World Health Organisation treatment decision algorithms for childhood tuberculosis
Diagnosing childhood pulmonary tuberculosis (TB) is a challenge. This led the Uganda National Tuberculosis and Leprosy Program (NTLP) to develop a clinical treatment decision algorithm (TDA) for children. However, there is limited data on its accuracy, and how it compares to new World Health Organization (WHO) TB TDAs for children. This study aimed to evaluate and compare the accuracy of the 2017 Uganda NTLP diagnostic algorithm with the 2022 WHO…
Assessment of scattered and leakage radiation from ultra-portable X-ray systems in chest imaging
Ultraportable (UP) X-ray devices are ideal to use in community-based settings, particularly for chest X-ray (CXR) screening of tuberculosis (TB). Unfortunately, there is insufficient guidance on the radiation safety of these devices. This study aims to determine the radiation dose by UP X-ray devices to both the public and radiographers compared to international dose limits. Radiation dose measurements were performed with four UP X-ray devices th…
Evaluating the impact of decentralized testing for tuberculosis in Ghana
Poor geographical accessibility to tuberculosis (TB) diagnostic services in Ghana is a key barrier to timely diagnosis. Decentralizing molecular testing for TB could improve TB case notification among underserved populations and enhance treatment initiation while avoiding unnecessary treatments. This study aims to project the epidemiological impact of decentralized TB testing at the country level. We developed an individual-based simulation of th…
Potential impact, costs, and benefits of population-wide screening interventions for tuberculosis in Viet Nam
Population-wide screening may accelerate the decline of tuberculosis (TB) incidence, but the optimal screening algorithm and duration must weigh resource considerations. We calibrated a deterministic transmission model to TB epidemiology in Viet Nam. We simulated three population-wide screening algorithms from 2025: sputum nucleic acid amplification tests (NAAT, Xpert MTB/RIF Ultra) only; chest radiography (CXR) followed by NAAT; and CXR-only wit…
Rapid diagnosis of pulmonary tuberculosis on induced sputum in children in a high burden setting for HIV and malnutrition
Microbiological diagnosis of childhood pulmonary tuberculosis can be challenging. We investigated the accuracy of Xpert MTB/RIF Ultra on the induced sputum, focused on high-risk groups (infants, malnourished children, and those living with HIV), where data is limited. Children (under 15 years) investigated for pulmonary tuberculosis at Dora Nginza Hospital, South Africa, were prospectively enrolled between January 2018 and January 2024, and follo…
Do sociodemographic factors modify the association between antenatal care utilisation and acute respiratory infection among infants in Ethiopia
Antenatal care (ANC) is vital for optimum maternal care and could provide an opportunity to prevent acute respiratory infection (ARI) in early childhood, particularly in low-resource settings; however, its impact on ARI remains underexplored. This study examined the association between ANC utilisation and ARI in Ethiopian infants, including stratified analyses by key socio-demographic factors. A total of 4,154 mother-infant pairs were analysed, u…
Computer-aided detection for radiological disease severity classification on chest radiograph in children with intra-thoracic tuberculosis
Implementation of the World Health Organization’s (WHO) recommended shorter 4-month treatment regimen for non-severe tuberculosis (TB) in children requires classification of disease severity on chest X-ray (CXR). Access to specialists for CXR interpretation is limited. We explored the use of computer-aided detection of CXR (“CAD”) to automate CXR classification of radiological disease severity. To do this, we combined three CXR datasets from chil…
Medicine (9 works) · Tuberculosis (7 works) · Tuberculosis Research and Epidemiology (7 works) · Pediatrics (5 works) · Child Nutrition and Water Access (3 works) · Epidemiology (3 works) · Global Maternal and Child Health (3 works) · Infectious Diseases and Tuberculosis (3 works) · Internal Medicine (3 works) · Logistic regression (3 works)