Ian Leck
Biographic Data
| ID | 6168252 |
|---|---|
| NAME | Ian Leck |
| GIVEN NAMES | Ian |
| FAMILY NAME | Leck |
| SIGNATURE | LECK I |
| AFFILIATIONS | University of Birmingham |
| VERIFIED | No |
| TOTAL WORKS | 16 |
| TOTAL CITATIONS | 4 |
| AUTHOR COUNT | 16 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1963 |
| LATEST PUBLICATION YEAR | 1996 |
| H-INDEX | 1 |
The Society for Social Medicine; 1956 to 1996
Birth prevalence of malformations in members of different ethnic groups and in the offspring of matings between them, in Birmingham, England
STUDY OBJECTIVES--The aims were: (1) to compare the birth prevalence of malformations in different ethnic groups and (2) to explore the reasons for the ethnic variations found by examining birth prevalence in the offspring of matings between ethnic groups. DESIGN--Analysis of data from a register of malformations and register of births. SETTING--Birmingham, England. SUBJECTS--A total of 432,778 infants (including stillbirths) born in 1960-84. MAI…
Methods in observational epidemiology
Space-time interaction in Hodgkin's disease in Greater Manchester
Knox's test for space-time interaction was applied to 922 cases of Hodgkin's disease which, according to the North Western Regional Cancer Registry, had presented in 1962-76 among the population of the region known before 1974 as the South East Lancashire Conurbation. In the series as a whole, there were statistically significant excesses of pairs of patients separated by time intervals of less than a year and distances of less than 1 km. Analysi…
Occupation and bladder cancer in Boston, USA, Manchester, UK, and Nagoya, Japan
Relations between occupational history and the development of cancer of the lower urinary tract ("bladder cancer") were evaluated in Boston, Massachusetts, USA, Manchester, UK, and Nagoya, Japan. Population-based series of incident cases and controls were identified and interviewed in each area. The present analysis was limited to men and was based on 430 cases and 397 controls in Boston, 399 cases and 493 controls in Manchester, and 226 cases an…
Effects of prescription charges on medical care
Malformations reported on birth certificates following influenza epidemics
A note on the blood groups of commonwealth immigrants to England
Ethnic differences in the incidence of malformations following migration
Medical and social needs of patients in hospitals for the mentally subnormal
The most significant finding was the heterogeneity of patients in each type of hospital-acute, mental, and chronic -and it was suggested that patients should be regrouped to bring together those with similar needs. This idea led to the concept of a balanced hospital community: a hospital centre designed to accommodate all classes of patients from a defined population in multiple buildings on a common site
Changes in the Incidence of Anencephalus
Marked changes in the incidence of anencephalus have repeatedly been observed in both Birmingham and Scotland (e.g. MacMahon, Record, and
Seasonal incidence of anencephalus
According to the most recent figures, anencephalus has become the second most common cause of stillbirth in England and Wales and the commonest in Scotland. The most revealing data are those published by the Registrar-General for Scotland, where causes of stillbirth have been registered since 1939 (22 years longer than in England and Wales). Between 1939 and 1963 they show a halving of the overall stillbirth rate and a slight increase in the inci…
Examination of the Incidence of Malformations for Evidence of Drug Teratogenesis
The discovery that thalidomide can cause human malformations has been followed in recent years by a large number of reports of malformations in the offspring of women who have taken other drugs in pregnancy. But it has remained uncertain whether any of these drugs are teratogenic, since those reporting on them have not been in a position to relate their findings to the distribution of malformations in the general population. There are two reasons…
Short-term Changes in the Incidence of Malformations
On at least two occasions, the examination of secular changes in the incidence of malformations has led to the identification of important aetiological agents. The discovery that rubella could cause congenital heart disease and cataract (Gregg, 1941) was based on studies of the incidence of these mal formations. Similarly, the association between the taking of thalidomide in pregnancy and ectromelia was first demonstrated by inquiries carried out…
Incidence of Malformations following Influenza Epidemics
Proteostasis dysfunction and activation of the unfolded protein response (UPR) are characteristic of all major neurodegenerative diseases. Nevertheless, although the UPR and proteostasis dysfunction has been studied in great detail in model organisms like yeast and mammalian cell lines, it has not yet been examined in neurons. In this study, we applied a viral vector-mediated expression of a reporter protein based on a UPR transcription factor, A…
Sources of Seasonal Variation in Recorded Length of Gestation
An examination of the birth records of New York City for the years 1957-59 reported by Hewitt (1961) indicated that pregnancies which terminated in the summer months tended to be of shorter duration than those which terminated in the winter. February births showed the longest gestations and August births the shortest, the estimated difference being between one and two days. It seemed important to decide whether this fluctuation had a biological o…
Space-time interaction in Hodgkin's disease in Greater Manchester
Knox's test for space-time interaction was applied to 922 cases of Hodgkin's disease which, according to the North Western Regional Cancer Registry, had presented in 1962-76 among the population of the region known before 1974 as the South East Lancashire Conurbation. In the series as a whole, there were statistically significant excesses of pairs of patients separated by time intervals of less than a year and distances of less than 1 km. Analysi…
Short-term Changes in the Incidence of Malformations
On at least two occasions, the examination of secular changes in the incidence of malformations has led to the identification of important aetiological agents. The discovery that rubella could cause congenital heart disease and cataract (Gregg, 1941) was based on studies of the incidence of these mal formations. Similarly, the association between the taking of thalidomide in pregnancy and ectromelia was first demonstrated by inquiries carried out…
Incidence of Malformations following Influenza Epidemics
Proteostasis dysfunction and activation of the unfolded protein response (UPR) are characteristic of all major neurodegenerative diseases. Nevertheless, although the UPR and proteostasis dysfunction has been studied in great detail in model organisms like yeast and mammalian cell lines, it has not yet been examined in neurons. In this study, we applied a viral vector-mediated expression of a reporter protein based on a UPR transcription factor, A…
Sources of Seasonal Variation in Recorded Length of Gestation
An examination of the birth records of New York City for the years 1957-59 reported by Hewitt (1961) indicated that pregnancies which terminated in the summer months tended to be of shorter duration than those which terminated in the winter. February births showed the longest gestations and August births the shortest, the estimated difference being between one and two days. It seemed important to decide whether this fluctuation had a biological o…
Examination of the Incidence of Malformations for Evidence of Drug Teratogenesis
The discovery that thalidomide can cause human malformations has been followed in recent years by a large number of reports of malformations in the offspring of women who have taken other drugs in pregnancy. But it has remained uncertain whether any of these drugs are teratogenic, since those reporting on them have not been in a position to relate their findings to the distribution of malformations in the general population. There are two reasons…
Seasonal incidence of anencephalus
According to the most recent figures, anencephalus has become the second most common cause of stillbirth in England and Wales and the commonest in Scotland. The most revealing data are those published by the Registrar-General for Scotland, where causes of stillbirth have been registered since 1939 (22 years longer than in England and Wales). Between 1939 and 1963 they show a halving of the overall stillbirth rate and a slight increase in the inci…
Medical and social needs of patients in hospitals for the mentally subnormal
The most significant finding was the heterogeneity of patients in each type of hospital-acute, mental, and chronic -and it was suggested that patients should be regrouped to bring together those with similar needs. This idea led to the concept of a balanced hospital community: a hospital centre designed to accommodate all classes of patients from a defined population in multiple buildings on a common site
Changes in the Incidence of Anencephalus
Marked changes in the incidence of anencephalus have repeatedly been observed in both Birmingham and Scotland (e.g. MacMahon, Record, and
A note on the blood groups of commonwealth immigrants to England
Ethnic differences in the incidence of malformations following migration
Malformations reported on birth certificates following influenza epidemics
Effects of prescription charges on medical care
Space-time interaction in Hodgkin's disease in Greater Manchester
Knox's test for space-time interaction was applied to 922 cases of Hodgkin's disease which, according to the North Western Regional Cancer Registry, had presented in 1962-76 among the population of the region known before 1974 as the South East Lancashire Conurbation. In the series as a whole, there were statistically significant excesses of pairs of patients separated by time intervals of less than a year and distances of less than 1 km. Analysi…
Occupation and bladder cancer in Boston, USA, Manchester, UK, and Nagoya, Japan
Relations between occupational history and the development of cancer of the lower urinary tract ("bladder cancer") were evaluated in Boston, Massachusetts, USA, Manchester, UK, and Nagoya, Japan. Population-based series of incident cases and controls were identified and interviewed in each area. The present analysis was limited to men and was based on 430 cases and 397 controls in Boston, 399 cases and 493 controls in Manchester, and 226 cases an…
Methods in observational epidemiology
Birth prevalence of malformations in members of different ethnic groups and in the offspring of matings between them, in Birmingham, England
STUDY OBJECTIVES--The aims were: (1) to compare the birth prevalence of malformations in different ethnic groups and (2) to explore the reasons for the ethnic variations found by examining birth prevalence in the offspring of matings between ethnic groups. DESIGN--Analysis of data from a register of malformations and register of births. SETTING--Birmingham, England. SUBJECTS--A total of 432,778 infants (including stillbirths) born in 1960-84. MAI…
The Society for Social Medicine; 1956 to 1996
Medicine (16 works) · Pediatrics (7 works) · Pediatrics (7 works) · Demography (6 works) · Environmental health (6 works) · Family medicine (5 works) · Incidence (geometry) (5 works) · Population (5 works) · Internal Medicine (4 works) · Internal Medicine (4 works)