Short-term Changes in the Incidence of Malformations
Bibliographic Data
| ID | 11180481 |
|---|---|
| Authors | Ian Leck, E L M Millar |
| Year | 1963 |
| Volume | 17 |
| Issue | 1 |
| Pages | 1-12 |
| Publication date | 1963-01-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Journal of Epidemiology and Community Health (JOURNAL) |
| Journal identifiers | ISSN: 0143-005X • E-ISSN: 1470-2738 |
| Publisher | BMJ (PUBLISHER • GB) |
| DOI | 10.1136/jech.17.1.1 |
| PMID | 13928951 |
| OpenAlex | W2031280837 |
| Language | EN |
| Citations received | 5 |
| References cited | 16 |
On at least two occasions, the examination of secular changes in the incidence of malformations has led to the identification of important aetiological agents. The discovery that rubella could cause congenital heart disease and cataract (Gregg, 1941) was based on studies of the incidence of these mal formations. Similarly, the association between the taking of thalidomide in pregnancy and ectromelia was first demonstrated by inquiries carried out be cause defects of this type had become commoner (Lenz, 1961; McBride, 1961). The increases in incidence caused by rubella and thalidomide were unnoticed until they became conspicuous enough to impress clinicians. It is clearly desirable that epidemics of malformations should be recognized before reaching such propor tions, and there is therefore a need for the examina tion of secular trends in large populations of births. In the present communication, data for Birmingham children born in 1957-61 are analysed in this way
Incidence (geometry) · Term (time) · Autopsy Techniques and Outcomes · Medicine · Viral Infections and Vectors · Pediatrics
| Unique citing works | 5 |
|---|---|
| Citations per year | 0,08 |
| Citation span | 1963 - 2014 (52) |
| Citation velocity | historical |
| Highly cited | No |