Makhotso Lekhooa
Biographic Data
| ID | 7274265 |
|---|---|
| NAME | Makhotso Lekhooa |
| GIVEN NAMES | Makhotso |
| FAMILY NAME | Lekhooa |
| SIGNATURE | LEKHOOA M |
| AFFILIATIONS | University of the Free State |
| ORCID | 0000-0002-7819-7697 |
| VERIFIED | Yes |
| TOTAL WORKS | 4 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 4 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2012 |
| LATEST PUBLICATION YEAR | 2022 |
| H-INDEX | 0 |
An acute dose-ranging evaluation of the antidepressant properties of Sceletium tortuosum (Zembrin®) versus escitalopram in the Flinders Sensitive Line rat
The development and use of a drug-induced immunosuppressed rat-model to screen Phela for mechanism of immune stimulation
Evaluation of Traditional Medicines III: The Mechanism of Immune Modulation by PHELA
PHELA is a herbal traditional medicine that is under development for use as an immune booster in immune compromised individuals. Therefore, the aim of this study was to determine PHELA's mechanism of action by observing for changes in cytokine profiles. Four groups of Sprague Dawley rats (n = 8) were treated daily and separately with normal-saline, cyclosporine-A, PHELA-only and PHELA+ cyclosporine-A. Thereafter, 4 animals from each group were sa…
Evaluation of Traditional Medicines II: The Use of Metabolite Peak-Kinetics to Monitor PHELA in Rat Plasma
PHELA is a herbal mixture of four African traditional medicinal plants that is under development by the Medical Research Council (MRC) for use as an immune stimulant in immune compromised individuals. Before major in vivo investigations could be conducted, there was a need to establish a plasma marker for concentration monitoring of PHELA. Chromatographic separation was achieved using a C18 RP column (250 mm × 4.6 mm × 5 μm), 70% acetonitrile in …
No prominent works on this page.
Evaluation of Traditional Medicines III: The Mechanism of Immune Modulation by PHELA
PHELA is a herbal traditional medicine that is under development for use as an immune booster in immune compromised individuals. Therefore, the aim of this study was to determine PHELA's mechanism of action by observing for changes in cytokine profiles. Four groups of Sprague Dawley rats (n = 8) were treated daily and separately with normal-saline, cyclosporine-A, PHELA-only and PHELA+ cyclosporine-A. Thereafter, 4 animals from each group were sa…
Evaluation of Traditional Medicines II: The Use of Metabolite Peak-Kinetics to Monitor PHELA in Rat Plasma
PHELA is a herbal mixture of four African traditional medicinal plants that is under development by the Medical Research Council (MRC) for use as an immune stimulant in immune compromised individuals. Before major in vivo investigations could be conducted, there was a need to establish a plasma marker for concentration monitoring of PHELA. Chromatographic separation was achieved using a C18 RP column (250 mm × 4.6 mm × 5 μm), 70% acetonitrile in …
The development and use of a drug-induced immunosuppressed rat-model to screen Phela for mechanism of immune stimulation
An acute dose-ranging evaluation of the antidepressant properties of Sceletium tortuosum (Zembrin®) versus escitalopram in the Flinders Sensitive Line rat
Medicine (4 works) · Biology (3 works) · Pharmacology (3 works) · Biochemistry (2 works) · Immune system (2 works) · Immunology (2 works) · In vitro (2 works) · Internal Medicine (2 works) · Mechanism of Action (2 works) · Traditional medicine (2 works)