Licínio Manco
Biographic Data
| ID | 76930 |
|---|---|
| NAME | Licínio Manco |
| GIVEN NAMES | Licínio |
| FAMILY NAME | Manco |
| SIGNATURE | MANCO L |
| AFFILIATIONS | University of Coimbra |
| ORCID | 0000-0002-2636-0288 |
| VERIFIED | Yes |
| TOTAL WORKS | 18 |
| TOTAL CITATIONS | 6 |
| AUTHOR COUNT | 18 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1999 |
| LATEST PUBLICATION YEAR | 2025 |
| H-INDEX | 2 |
Subclades of the Y-chromosome haplogroup R1b-M269 in Portuguese samples: F1343 as a common DF27 sublineage
The internal branches of R1b-M269 (R1b1a1b) have been poorly analyzed in the Portuguese population. The present study aims to improve the understanding of the phylogenetic structure of this main haplogroup within the country. We analyzed 94 individuals, primarily from the central region of Portugal, previously identified as having the derived allele for the R1b-M269 marker. The R1b-M269 subhaplogroups S116/P312 and U106 were found with frequencie…
Differential sex‐association between PCSK1 polymorphisms and obesity risk in Portuguese children
Sickle cell trait in São Tomé e Príncipe: A population-based prevalence study in women of reproductive age
The prevalence of sickle cell trait in São Tomé e Príncipe ranks high in the West African region. The country should follow international guidelines, implementing newborn screening and comprehensive healthcare management
Analysis of Human Y Chromosome Haplogroup E-M81 Sublineages in Portuguese Samples
The human Y-chromosome haplogroup E-M81 is predominant in northwestern Africa and almost absent elsewhere, except for the Iberian Peninsula. In the present study, we investigated the internal branches of E-M81 (E1b1b1b1a) in 29 unrelated men from mainland Portugal. All individuals sampled carried the derived allele for the marker M183 (E1b1b1b1a1), and all but two had the derived allele for the marker SM001. Eleven individuals carried the derived…
Physical activity and the association between the FTO rs9939609 polymorphism and obesity in Portuguese children aged 3 to 11 years
High AMY1 copy number protects against obesity in Portuguese young adults
The results suggest that high AMY1 gene copy number protects against obesity in Portuguese young adults
The Eastern side of the Westernmost Europeans: Insights from subclades within Y‐chromosome haplogroup J‐M304
While previous inferences based on modern haplogroup J Y-chromosomes implicated a main Neolithic dissemination, here we propose a later arrival of J lineages into Iberia using a combination of novel Portuguese Y-chromosomal data and recent evidence from ancient DNA. Our analysis suggests that a substantial tranche of J1-M267 lineages was likely carried into the Iberian Peninsula as a consequence of the trans-Mediterranean contacts during the firs…
Influence of physical activity on the association between the FTO variant rs9939609 and adiposity in young adults
This study reveals interactions between rs9939609 and PA on obesity indices in Portuguese young adults, suggesting a change in the different body components (lean and fat mass) depending on the FTO genotypes
Y -chromosome diversity in central Portugal reveals signatures of ancient maritime expansions
The genetic diversity of human populations in Portugal results from several different demographic events that occurred in distinct prehistorical and historical periods. The main objective of this study was to examine if patterns of Y-chromosome diversity explained by ancient maritime Mediterranean expansions can be observed in Coimbra district (central-west region of Portugal). A total of 125 male DNA samples were typed for 16 Y-SNPs and eight Y-…
SLC40A1 Q248H allele frequencies and associated SLC40A1 haplotypes in three West African population samples
This study confirmed the presence of Q248H mutation at polymorphic frequencies in three native sub-Saharan populations. Analysis of two additional markers in the same gene support a single origin of the mutant allele c.744T in the haplotype background IVS1( - 24)G/(CGG)(7)
Allele frequencies of 6 STR loci (TH01, TPOX, CSF1PO, D13S317, D16S539 and D7S820) in São Tomé e Príncipe (West Africa)
Allele frequencies of six autosomal short tandem repeat (STR) markers \n(TH01, TPOX, CSF1PO, D13S317, D7S820 and D16S539) were estimated in a \npopulation sample (N=53-85) of unrelated individuals from São Tomé e Principe \n(West Africa). No deviations from Hardy-Weinberg equilibrium were observed for \nall loci. Allele frequency distribution and heterozygosity values were similar with \nthose from other sub-Saharan African populations
Phylogeographic analysis of paternal lineages in NE Portuguese Jewish communities
The establishment of Jewish communities in the territory of contemporary Portugal is archaeologically documented since the 3rd century CE, but their settlement in Trás‐os‐Montes (NE Portugal) has not been proved before the 12th century. The Decree of Expulsion followed by the establishment of the Inquisition, both around the beginning of the 16th century, accounted for a significant exodus, as well as the establishment of crypto‐Jewish communitie…
Analysis of TPI gene promoter variation in three sub‐Saharan Africa population samples
Population samples from Angola, Mozambique, and S. Tomé e Príncipe were screened for the TPI gene promoter variants -5A-->G, -8G-->A and -24T-->G. Three haplotypes were identified in the three populations: the haplotype -5A-8G-24T (average frequency 65.3%) and two less common haplotypes -5G-8G-24T (average frequency 24.7%) and -5G-8A-24T (average frequency 10.0%). A population sample from Central Portugal showed the haplotype -5A-8G-24T in 139 ch…
Estudo populacional de 6 STRs (TH01, TPOX, CSF1PO, D7S820, D13S317 e D16S539) na região Centro de Portugal
As frequências alélicas de 6 STRs autossómicos (TH01, TPOX, CSF1PO, \nD7S820, D13S317 e D16S539), correntemente utilizados em estudos forenses, foram \nestimadas numa amostra de indivíduos não aparentados naturais da região Centro \nde Portugal (N=70-104). Não se verificaram desvios significativos ao equilíbrio de \nHardy-Weinberg para os marcadores estudados. Os resultados foram comparados \ncom os obtidos em estudos realizados noutras regiões d…
G6PD Deficient Alleles and Haplotype Analysis of Human G6PD Locus in São Tomé e Príncipe (West Africa)
A population sample from São Tomé e Príncipe (West Africa) was screened for the G6PD-deficient variants A- (376G/202A), Betica (376G/968C), and Santa Maria (376G/542T). G6PD locus haplotype diversity was also investigated using six intragenic RFLPs (FokI, PvuII, BspHI, PstI, BclI, NlaIII) and a (CTT)n microsatellite 18.61 kb within the G6PD locus. The estimated frequencies of the G6PD*B normal allele, the G6PD*A variant (376G), and the G6PD*A- al…
Polimorfismos genéticos de ESD, GLO1, GPT e PGM1 em São Tomé e Príncipe
The distribution of phenotypes of the red cell esterase D (ESD), glyoxalase 1 (GLO1), glutamate pyruvate transaminase (GPT) and phosphoglucomutase 1 (PGM1) were analysed by starch gel electrophoresis in unrelated native-born residents in Sao Tome and Principe, for the purpose of genetic characterization of this population. The allele frequencies found were: ESD* = 0.929, ESD*2 = 0.071 (N =145); GLO 1 *1= 0.347, GLO1 *2 = 0.653 (N = 154); GPT*1=0.…
Genética populacional de três polimorfismos intragénicos do gene da doença de Machado-Joseph (MJD1) na Região Centro de Portugal e nos Açores
Res_por:Neste trabalho procedemos ao estudo de tres polimorfismos intragenicos do gene da doenca de Machado-Joseph (669A/G; 987C/G e 1118A/C) em duas amostras populacionais de individuos saudaveis nao aparentados e nao pertencentes a familias MJD, das regioes Centro de Portugal e Acores. As frequencias alelicas encontradas nao diferem das publicadas para outras populacoes de origem Europeia. Foram encontrados os haplotipos comuns G-G-C e A-C-A, c…
Distribution of AMY2 polymorphism in S. Tomé and Príncipe (West Africa)
The genetic polymorphism of AMY2 was studied in the population of S. Tomé and Príncipe (West Africa) using agarose gel electrophoresis. AMY2 frequencies are reported for the first time in a subSaharian population. The gene frequencies found were: AMY2*1=0.948, AMY2*3=0.052 (N=173)
Phylogeographic analysis of paternal lineages in NE Portuguese Jewish communities
The establishment of Jewish communities in the territory of contemporary Portugal is archaeologically documented since the 3rd century CE, but their settlement in Trás‐os‐Montes (NE Portugal) has not been proved before the 12th century. The Decree of Expulsion followed by the establishment of the Inquisition, both around the beginning of the 16th century, accounted for a significant exodus, as well as the establishment of crypto‐Jewish communitie…
Y -chromosome diversity in central Portugal reveals signatures of ancient maritime expansions
The genetic diversity of human populations in Portugal results from several different demographic events that occurred in distinct prehistorical and historical periods. The main objective of this study was to examine if patterns of Y-chromosome diversity explained by ancient maritime Mediterranean expansions can be observed in Coimbra district (central-west region of Portugal). A total of 125 male DNA samples were typed for 16 Y-SNPs and eight Y-…
Distribution of AMY2 polymorphism in S. Tomé and Príncipe (West Africa)
The genetic polymorphism of AMY2 was studied in the population of S. Tomé and Príncipe (West Africa) using agarose gel electrophoresis. AMY2 frequencies are reported for the first time in a subSaharian population. The gene frequencies found were: AMY2*1=0.948, AMY2*3=0.052 (N=173)
Genética populacional de três polimorfismos intragénicos do gene da doença de Machado-Joseph (MJD1) na Região Centro de Portugal e nos Açores
Res_por:Neste trabalho procedemos ao estudo de tres polimorfismos intragenicos do gene da doenca de Machado-Joseph (669A/G; 987C/G e 1118A/C) em duas amostras populacionais de individuos saudaveis nao aparentados e nao pertencentes a familias MJD, das regioes Centro de Portugal e Acores. As frequencias alelicas encontradas nao diferem das publicadas para outras populacoes de origem Europeia. Foram encontrados os haplotipos comuns G-G-C e A-C-A, c…
Polimorfismos genéticos de ESD, GLO1, GPT e PGM1 em São Tomé e Príncipe
The distribution of phenotypes of the red cell esterase D (ESD), glyoxalase 1 (GLO1), glutamate pyruvate transaminase (GPT) and phosphoglucomutase 1 (PGM1) were analysed by starch gel electrophoresis in unrelated native-born residents in Sao Tome and Principe, for the purpose of genetic characterization of this population. The allele frequencies found were: ESD* = 0.929, ESD*2 = 0.071 (N =145); GLO 1 *1= 0.347, GLO1 *2 = 0.653 (N = 154); GPT*1=0.…
G6PD Deficient Alleles and Haplotype Analysis of Human G6PD Locus in São Tomé e Príncipe (West Africa)
A population sample from São Tomé e Príncipe (West Africa) was screened for the G6PD-deficient variants A- (376G/202A), Betica (376G/968C), and Santa Maria (376G/542T). G6PD locus haplotype diversity was also investigated using six intragenic RFLPs (FokI, PvuII, BspHI, PstI, BclI, NlaIII) and a (CTT)n microsatellite 18.61 kb within the G6PD locus. The estimated frequencies of the G6PD*B normal allele, the G6PD*A variant (376G), and the G6PD*A- al…
Analysis of TPI gene promoter variation in three sub‐Saharan Africa population samples
Population samples from Angola, Mozambique, and S. Tomé e Príncipe were screened for the TPI gene promoter variants -5A-->G, -8G-->A and -24T-->G. Three haplotypes were identified in the three populations: the haplotype -5A-8G-24T (average frequency 65.3%) and two less common haplotypes -5G-8G-24T (average frequency 24.7%) and -5G-8A-24T (average frequency 10.0%). A population sample from Central Portugal showed the haplotype -5A-8G-24T in 139 ch…
Estudo populacional de 6 STRs (TH01, TPOX, CSF1PO, D7S820, D13S317 e D16S539) na região Centro de Portugal
As frequências alélicas de 6 STRs autossómicos (TH01, TPOX, CSF1PO, \nD7S820, D13S317 e D16S539), correntemente utilizados em estudos forenses, foram \nestimadas numa amostra de indivíduos não aparentados naturais da região Centro \nde Portugal (N=70-104). Não se verificaram desvios significativos ao equilíbrio de \nHardy-Weinberg para os marcadores estudados. Os resultados foram comparados \ncom os obtidos em estudos realizados noutras regiões d…
Phylogeographic analysis of paternal lineages in NE Portuguese Jewish communities
The establishment of Jewish communities in the territory of contemporary Portugal is archaeologically documented since the 3rd century CE, but their settlement in Trás‐os‐Montes (NE Portugal) has not been proved before the 12th century. The Decree of Expulsion followed by the establishment of the Inquisition, both around the beginning of the 16th century, accounted for a significant exodus, as well as the establishment of crypto‐Jewish communitie…
SLC40A1 Q248H allele frequencies and associated SLC40A1 haplotypes in three West African population samples
This study confirmed the presence of Q248H mutation at polymorphic frequencies in three native sub-Saharan populations. Analysis of two additional markers in the same gene support a single origin of the mutant allele c.744T in the haplotype background IVS1( - 24)G/(CGG)(7)
Allele frequencies of 6 STR loci (TH01, TPOX, CSF1PO, D13S317, D16S539 and D7S820) in São Tomé e Príncipe (West Africa)
Allele frequencies of six autosomal short tandem repeat (STR) markers \n(TH01, TPOX, CSF1PO, D13S317, D7S820 and D16S539) were estimated in a \npopulation sample (N=53-85) of unrelated individuals from São Tomé e Principe \n(West Africa). No deviations from Hardy-Weinberg equilibrium were observed for \nall loci. Allele frequency distribution and heterozygosity values were similar with \nthose from other sub-Saharan African populations
Y -chromosome diversity in central Portugal reveals signatures of ancient maritime expansions
The genetic diversity of human populations in Portugal results from several different demographic events that occurred in distinct prehistorical and historical periods. The main objective of this study was to examine if patterns of Y-chromosome diversity explained by ancient maritime Mediterranean expansions can be observed in Coimbra district (central-west region of Portugal). A total of 125 male DNA samples were typed for 16 Y-SNPs and eight Y-…
Influence of physical activity on the association between the FTO variant rs9939609 and adiposity in young adults
This study reveals interactions between rs9939609 and PA on obesity indices in Portuguese young adults, suggesting a change in the different body components (lean and fat mass) depending on the FTO genotypes
The Eastern side of the Westernmost Europeans: Insights from subclades within Y‐chromosome haplogroup J‐M304
While previous inferences based on modern haplogroup J Y-chromosomes implicated a main Neolithic dissemination, here we propose a later arrival of J lineages into Iberia using a combination of novel Portuguese Y-chromosomal data and recent evidence from ancient DNA. Our analysis suggests that a substantial tranche of J1-M267 lineages was likely carried into the Iberian Peninsula as a consequence of the trans-Mediterranean contacts during the firs…
High AMY1 copy number protects against obesity in Portuguese young adults
The results suggest that high AMY1 gene copy number protects against obesity in Portuguese young adults
Physical activity and the association between the FTO rs9939609 polymorphism and obesity in Portuguese children aged 3 to 11 years
Analysis of Human Y Chromosome Haplogroup E-M81 Sublineages in Portuguese Samples
The human Y-chromosome haplogroup E-M81 is predominant in northwestern Africa and almost absent elsewhere, except for the Iberian Peninsula. In the present study, we investigated the internal branches of E-M81 (E1b1b1b1a) in 29 unrelated men from mainland Portugal. All individuals sampled carried the derived allele for the marker M183 (E1b1b1b1a1), and all but two had the derived allele for the marker SM001. Eleven individuals carried the derived…
Differential sex‐association between PCSK1 polymorphisms and obesity risk in Portuguese children
Sickle cell trait in São Tomé e Príncipe: A population-based prevalence study in women of reproductive age
The prevalence of sickle cell trait in São Tomé e Príncipe ranks high in the West African region. The country should follow international guidelines, implementing newborn screening and comprehensive healthcare management
Subclades of the Y-chromosome haplogroup R1b-M269 in Portuguese samples: F1343 as a common DF27 sublineage
The internal branches of R1b-M269 (R1b1a1b) have been poorly analyzed in the Portuguese population. The present study aims to improve the understanding of the phylogenetic structure of this main haplogroup within the country. We analyzed 94 individuals, primarily from the central region of Portugal, previously identified as having the derived allele for the R1b-M269 marker. The R1b-M269 subhaplogroups S116/P312 and U106 were found with frequencie…
Biology (15 works) · Genetics (11 works) · Gene (10 works) · Allele (9 works) · Demography (9 works) · Population (9 works) · Forensic and Genetic Research (7 works) · Haplotype (7 works) · Geography (6 works) · Medicine (6 works)