Paul McKeigue
Biographic Data
| ID | 7797875 |
|---|---|
| NAME | Paul McKeigue |
| GIVEN NAMES | Paul |
| FAMILY NAME | McKeigue |
| SIGNATURE | MCKEIGUE P |
| AFFILIATIONS | London School of Hygiene & Tropical Medicine |
| ORCID | 0000-0002-5217-1034 |
| VERIFIED | Yes |
| TOTAL WORKS | 10 |
| TOTAL CITATIONS | 5 |
| AUTHOR COUNT | 10 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1988 |
| LATEST PUBLICATION YEAR | 2011 |
| H-INDEX | 1 |
O1-2.2 Sparse instrumental variables: An integrative approach to biomarker validation
We introduce the Sparse Instrumental Variable (SPIV) framework for distinguishing causal and non-causal explanations of associations between biomarkers and diseases. SPIV overcomes the key limitations of the classic instrumental variable (Mendelian Randomisation) methods for learning the direction of causality, by allowing for pleiotropic genotypic effects on disease outcomes. SPIV extends the recently introduced Likelihood-based Causality Model …
The 10/66 Dementia Research Group's fully operationalised DSM-IV dementia computerized diagnostic algorithm, compared with the 10/66 dementia algorithm and a clinician diagnosis: A population validati…
The DSM-IV criterion, strictly applied, defines a narrow category of unambiguous dementia characterized by marked impairment. It may be specific but incompletely sensitive to clinically relevant cases. The 10/66 dementia diagnosis defines a broader category that may be more sensitive, identifying genuine cases beyond those defined by our DSM-IV algorithm, with relevance to the estimation of the population burden of this disorder
MGEA5 ‐14 polymorphism and type 2 diabetes in Mexico City
A family‐based study has recently reported that a variant located in intron 10 of the gene MGEA5 increases susceptibility to Type 2 Diabetes (T2D). We evaluated the distribution of this SNP in a sample of T2D patients ( N = 271) and controls ( N = 244) from Mexico City. The frequency of the T allele was higher in the cases (2.6%) than in the controls (1.8%). After adjusting for age, sex, BMI, education, and individual ancestry the odds ratio was …
The protocols for the 10/66 dementia research group population-based research programme
The 10/66 DRG baseline population-based studies are nearly complete. The incidence phase will be completed in 2009. All investigators are committed to establish an anonymised file sharing archive with monitored public access. Our aim is to create an evidence base to empower advocacy, raise awareness about dementia, and ensure that the health and social care needs of older people are anticipated and met
Skin pigmentation, biogeographical ancestry and admixture mapping
Ancestral proportions and admixture dynamics in geographically defined African Americans living in South Carolina
We analyzed admixture in samples of six different African-American populations from South Carolina: Gullah-speaking Sea Islanders in coastal South Carolina, residents of four counties in the "Low Country" (Berkeley, Charleston, Colleton, and Dorchester), and persons living in the city of Columbia, located in central South Carolina. We used a battery of highly informative autosomal, mtDNA, and Y-chromosome markers. Two of the autosomal markers (FY…
Cross sectional analysis of mortality by country of birth in england and wales, 1970-92
Objective: To compare mortalities for selected groups of immigrants with the national average. Design: Analysis of mortality for adults aged 20-69 in 1970-2 and 1989-92 using population data from 1971 and 1991 censuses. Mortality of Scottish and Irish immigrants aged 25-74 was also compared with mortality in Scotland and Ireland for 1991. Setting: England and Wales. Main outcome measures: Standardised mortality ratios for deaths from all causes, …
Prediction of general practice workload from census based social deprivation scores
STUDY OBJECTIVE--The aim was to compare the ability of census based social deprivation scores devised by Jarman, Carstairs, and Townsend to predict workload in general practice. DESIGN--This was a prospective study of 140,050 patients registered with general practices over one year from 1 July 1981 (Third National Morbidity Survey). Main outcome measures were workload score for each patient, defined as a weighted sum of consultations at the surge…
Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians
The politics of health information
Issues related to research in health and stress must be some of the most controversial, often leading to total rejection of all that is written. Thus, the title of this book is likely to attract attention, particularly when it is part of an established series and has a distinguished list of contributors. In a subject area where there is lack of clarity of definitions, the diversity of approach from different disciplines, the comprehensive reviews…
Prediction of general practice workload from census based social deprivation scores
STUDY OBJECTIVE--The aim was to compare the ability of census based social deprivation scores devised by Jarman, Carstairs, and Townsend to predict workload in general practice. DESIGN--This was a prospective study of 140,050 patients registered with general practices over one year from 1 July 1981 (Third National Morbidity Survey). Main outcome measures were workload score for each patient, defined as a weighted sum of consultations at the surge…
The politics of health information
Issues related to research in health and stress must be some of the most controversial, often leading to total rejection of all that is written. Thus, the title of this book is likely to attract attention, particularly when it is part of an established series and has a distinguished list of contributors. In a subject area where there is lack of clarity of definitions, the diversity of approach from different disciplines, the comprehensive reviews…
Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians
Prediction of general practice workload from census based social deprivation scores
STUDY OBJECTIVE--The aim was to compare the ability of census based social deprivation scores devised by Jarman, Carstairs, and Townsend to predict workload in general practice. DESIGN--This was a prospective study of 140,050 patients registered with general practices over one year from 1 July 1981 (Third National Morbidity Survey). Main outcome measures were workload score for each patient, defined as a weighted sum of consultations at the surge…
Cross sectional analysis of mortality by country of birth in england and wales, 1970-92
Objective: To compare mortalities for selected groups of immigrants with the national average. Design: Analysis of mortality for adults aged 20-69 in 1970-2 and 1989-92 using population data from 1971 and 1991 censuses. Mortality of Scottish and Irish immigrants aged 25-74 was also compared with mortality in Scotland and Ireland for 1991. Setting: England and Wales. Main outcome measures: Standardised mortality ratios for deaths from all causes, …
Ancestral proportions and admixture dynamics in geographically defined African Americans living in South Carolina
We analyzed admixture in samples of six different African-American populations from South Carolina: Gullah-speaking Sea Islanders in coastal South Carolina, residents of four counties in the "Low Country" (Berkeley, Charleston, Colleton, and Dorchester), and persons living in the city of Columbia, located in central South Carolina. We used a battery of highly informative autosomal, mtDNA, and Y-chromosome markers. Two of the autosomal markers (FY…
Skin pigmentation, biogeographical ancestry and admixture mapping
MGEA5 ‐14 polymorphism and type 2 diabetes in Mexico City
A family‐based study has recently reported that a variant located in intron 10 of the gene MGEA5 increases susceptibility to Type 2 Diabetes (T2D). We evaluated the distribution of this SNP in a sample of T2D patients ( N = 271) and controls ( N = 244) from Mexico City. The frequency of the T allele was higher in the cases (2.6%) than in the controls (1.8%). After adjusting for age, sex, BMI, education, and individual ancestry the odds ratio was …
The protocols for the 10/66 dementia research group population-based research programme
The 10/66 DRG baseline population-based studies are nearly complete. The incidence phase will be completed in 2009. All investigators are committed to establish an anonymised file sharing archive with monitored public access. Our aim is to create an evidence base to empower advocacy, raise awareness about dementia, and ensure that the health and social care needs of older people are anticipated and met
The 10/66 Dementia Research Group's fully operationalised DSM-IV dementia computerized diagnostic algorithm, compared with the 10/66 dementia algorithm and a clinician diagnosis: A population validati…
The DSM-IV criterion, strictly applied, defines a narrow category of unambiguous dementia characterized by marked impairment. It may be specific but incompletely sensitive to clinically relevant cases. The 10/66 dementia diagnosis defines a broader category that may be more sensitive, identifying genuine cases beyond those defined by our DSM-IV algorithm, with relevance to the estimation of the population burden of this disorder
O1-2.2 Sparse instrumental variables: An integrative approach to biomarker validation
We introduce the Sparse Instrumental Variable (SPIV) framework for distinguishing causal and non-causal explanations of associations between biomarkers and diseases. SPIV overcomes the key limitations of the classic instrumental variable (Mendelian Randomisation) methods for learning the direction of causality, by allowing for pleiotropic genotypic effects on disease outcomes. SPIV extends the recently introduced Likelihood-based Causality Model …
Medicine (8 works) · Population (7 works) · Demography (6 works) · Environmental health (5 works) · Allele (3 works) · Allele frequency (3 works) · Biology (3 works) · Gene (3 works) · Chronic Disease Management Strategies (2 works) · Dementia (2 works)