Ancestral proportions and admixture dynamics in geographically defined African Americans living in South Carolina

Bibliographic Data

ID8311799
AuthorsEsteban J Parra (0000-0002-2057-8577, Pennsylvania State University), Rick A Kittles (0000-0002-5004-4437, Howard University), George Argyropoulos (0000-0002-3675-2138, Medical University of South Carolina), Carrie Lynn Pfaff (Pennsylvania State University), K Hiester (Pennsylvania State University), Carolina Bonilla (0000-0002-9972-6383, Pennsylvania State University), Nadeje Sylvester (Howard University), D Parrish-Gause (Howard University), W Timothy Garvey (0000-0003-0822-0860, Medical University of South Carolina), Li Jin (0000-0001-9201-2321, The University of Texas Health Science Center at Houston), P M McKeigue, Paul McKeigue (0000-0002-5217-1034, London School of Hygiene & Tropical Medicine), M Ilyas Kamboh (0000-0002-3453-1438, University of Pittsburgh), R E Ferrell (University of Pittsburgh), William S Pollitzer (University of North Carolina at Chapel Hill), Mark D Shriver (0000-0003-0006-0479, Pennsylvania State University, corresponding author)
Year2001
Volume114
Issue1
Pages18-29
Publication date2001-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Physical Anthropology (JOURNAL)
Journal identifiersISSN: 0002-9483 • E-ISSN: 1096-8644
PublisherWiley (PUBLISHER • GB)
DOI10.1002/1096-8644(200101)114:1<18::aid-ajpa1002>3.0.co;2-2
PMID11150049
OpenAlexW1975365488
LanguageEN
Citations received34
References cited29

We analyzed admixture in samples of six different African-American populations from South Carolina: Gullah-speaking Sea Islanders in coastal South Carolina, residents of four counties in the "Low Country" (Berkeley, Charleston, Colleton, and Dorchester), and persons living in the city of Columbia, located in central South Carolina. We used a battery of highly informative autosomal, mtDNA, and Y-chromosome markers. Two of the autosomal markers (FY and AT3) are linked and lie 22 cM apart on chromosome 1. The results of this study indicate, in accordance with previous historical, cultural, and anthropological evidence, a very low level of European admixture in the Gullah Sea Islanders (m = 3.5 +/- 0.9%). The proportion of European admixture is higher in the Low Country (m ranging between 9. 9 +/- 1.8% and 14.0 +/- 1.9%), and is highest in Columbia (m = 17.7 +/- 3.1%). A sex-biased European gene flow and a small Native American contribution to the African-American gene pool are also evident in these data. We studied the pattern of pairwise allelic associations between the FY locus and the nine other autosomal markers in our samples. In the combined sample from the Low Country (N = 548), a high level of linkage disequilibrium was observed between the linked markers, FY and AT3. Additionally, significant associations were also detected between FY and 4 of the 8 unlinked markers, suggesting the existence of significant genetic structure in this population. A continuous gene flow model of admixture could explain the observed pattern of genetic structure. A test conditioning on the overall admixture of each individual showed association of ancestry between the two linked markers (FY and AT3), but not between any of the unlinked markers, as theory predicts. Thus, even in the presence of genetic structure due to continuous gene flow or some other factor, it is possible to differentiate associations due to linkage from spurious associations due to genetic structure.

Allele · Allele frequency · Biology · Ethnic group · Gene · Gene flow · Genetic variation · Geography · Haplotype · Linkage Disequilibrium · Locus (genetics) · Population · Sociology · South carolina · Anthropology · Demography · Forensic and Genetic Research · Genetics · Molecular Biology Techniques and Applications · Race, Genetics, and Society

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