Gregory M Brown
Biographic Data
| ID | 7955261 |
|---|---|
| NAME | Gregory M Brown |
| GIVEN NAMES | Gregory M |
| FAMILY NAME | Brown |
| SIGNATURE | BROWN G M |
| AFFILIATIONS | Clarke University |
| ORCID | 0000-0003-3222-9013 |
| VERIFIED | Yes |
| TOTAL WORKS | 9 |
| TOTAL CITATIONS | 0 |
| WORKS AS AUTHOR | 9 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 1972 |
| LATEST PUBLICATION YEAR | 2021 |
| H-INDEX | 0 |
Potential Genetic Overlap Between Insomnia and Sleep Symptoms in Major Depressive Disorder
Background: The prevalence of insomnia and hypersomnia in depressed individuals is substantially higher than that found in the general population. Unfortunately, these concurrent sleep problems can have profound effects on the disease course. Although the full biology of sleep remains to be elucidated, a recent genome-wide association (GWAS) of insomnia, and other sleep traits in over 1 million individuals was recently published and provides many…
A Randomized, Double-Blind, Placebo-Controlled Crossover Study of the Effect of Exogenous Melatonin on Delayed Sleep Phase Syndrome
OBJECTIVE: The effects of exogenous melatonin on sleep, daytime sleepiness, fatigue, and alertness were investigated in 22 patients with delayed sleep phase syndrome whose nocturnal sleep was restricted to the interval from 24:00 to 08:00 hours. This study was a randomized, double-blind, placebo-controlled crossover trial. Subjects received either placebo or melatonin (5 mg) daily for 4 weeks, underwent a 1-week washout period, and then were give…
Psychoneuroimmunology
Anxiety Induced by Flooding Therapy for Phobias Does Not Elicit Prolactin Secretory Response
Eight subjects with severe phobias to insects and small animals had blood samples taken for measurement of prolactin concentration at regular intervals during five sessions of 3 hr duration each. Severe anxiety was induced by treating the phobia with in vivo flooding during the middle hour of the third and fourth sessions. Despite intense anxiety experienced by the subjects, they showed no change in plasma prolactin levels
TSH and LH Responses in Subtypes of Depression
TRH and LHRH were simultaneously infused into a group of five male patients with primary unipolar depression and four male secondary depressed patients. Blood samples were measured for LH and TSH just before and two hours following infusion. Six healthy male subjects matched for age were similarly studied. Our results showed: 1) that basal levels of TSH and LH were not different in any of the three groups of subjects, 2) TSH responses in the thre…
Hypothalamic Function as Related to Body Weight and Body Fat in Anorexia Nervosa
Percentage body fat is predictive of the onset of menstruation at puberty. In anorexia nervosa a relationship between luteinizing hormone (LH) levels and percentage weight loss has been reported. In the current study the relationship of percentage body fat and of percentage weight loss to LH and LH reactivity was examined in anorexia nervosa. Fifteen women with anorexia nervosa were studied. The resting levels of LH were measured, and in seven of…
Growth Hormone and Cortisol Responses, Tranquillizer Usage, and Their Association with Survival From Myocardial Infarction
Sixty-six patients consecutively admitted to a Coronary Care Unit with a diagnosis of myocardial infarction were evaluated physically, psychologically, and neuroendocrinologically. Records were also kept of appetite and drug intake. Serum cortisol and growth hormone, physical, and mood variables were evaluated daily and the neuroendocrine measures were also taken serially at the time of removal from the cardiac monitor. At the end of the 2 years …
Corticosterone, Prolactin, and Growth Hormone Responses to Handling and New Environment in the Rat
Temporal characteristics of hormonal responses to handling and novel environment were studied in the rat in order to determine whether the same factors which modify corticosterone responses, i.e., time of day and type of stimulus, also modify prolactin and GH responses. Resting corticosterone showed the expected difference between crest and trough of the diurnal cycle. In contrast, GH and prolactin showed no difference at these times. Prolactin e…
Psychologic and Neural Regulation of Growth Hormone Secretion
A wide variety of stressful stimuli, both physical and psychologic, cause GH discharge in both man and monkey in a manner reminiscent of the changes in ACTH secretion under similar circumstances. The hypothalamus appears to mediate acute changes in GH release as evidenced by the finding that basal hypothalamic or infundibular lesions and pituitary stalk section blocked the acute GH response to hypoglycemia in rat, monkey and man. Changes in GH re…
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Psychologic and Neural Regulation of Growth Hormone Secretion
A wide variety of stressful stimuli, both physical and psychologic, cause GH discharge in both man and monkey in a manner reminiscent of the changes in ACTH secretion under similar circumstances. The hypothalamus appears to mediate acute changes in GH release as evidenced by the finding that basal hypothalamic or infundibular lesions and pituitary stalk section blocked the acute GH response to hypoglycemia in rat, monkey and man. Changes in GH re…
Corticosterone, Prolactin, and Growth Hormone Responses to Handling and New Environment in the Rat
Temporal characteristics of hormonal responses to handling and novel environment were studied in the rat in order to determine whether the same factors which modify corticosterone responses, i.e., time of day and type of stimulus, also modify prolactin and GH responses. Resting corticosterone showed the expected difference between crest and trough of the diurnal cycle. In contrast, GH and prolactin showed no difference at these times. Prolactin e…
Hypothalamic Function as Related to Body Weight and Body Fat in Anorexia Nervosa
Percentage body fat is predictive of the onset of menstruation at puberty. In anorexia nervosa a relationship between luteinizing hormone (LH) levels and percentage weight loss has been reported. In the current study the relationship of percentage body fat and of percentage weight loss to LH and LH reactivity was examined in anorexia nervosa. Fifteen women with anorexia nervosa were studied. The resting levels of LH were measured, and in seven of…
Growth Hormone and Cortisol Responses, Tranquillizer Usage, and Their Association with Survival From Myocardial Infarction
Sixty-six patients consecutively admitted to a Coronary Care Unit with a diagnosis of myocardial infarction were evaluated physically, psychologically, and neuroendocrinologically. Records were also kept of appetite and drug intake. Serum cortisol and growth hormone, physical, and mood variables were evaluated daily and the neuroendocrine measures were also taken serially at the time of removal from the cardiac monitor. At the end of the 2 years …
TSH and LH Responses in Subtypes of Depression
TRH and LHRH were simultaneously infused into a group of five male patients with primary unipolar depression and four male secondary depressed patients. Blood samples were measured for LH and TSH just before and two hours following infusion. Six healthy male subjects matched for age were similarly studied. Our results showed: 1) that basal levels of TSH and LH were not different in any of the three groups of subjects, 2) TSH responses in the thre…
Anxiety Induced by Flooding Therapy for Phobias Does Not Elicit Prolactin Secretory Response
Eight subjects with severe phobias to insects and small animals had blood samples taken for measurement of prolactin concentration at regular intervals during five sessions of 3 hr duration each. Severe anxiety was induced by treating the phobia with in vivo flooding during the middle hour of the third and fourth sessions. Despite intense anxiety experienced by the subjects, they showed no change in plasma prolactin levels
Psychoneuroimmunology
A Randomized, Double-Blind, Placebo-Controlled Crossover Study of the Effect of Exogenous Melatonin on Delayed Sleep Phase Syndrome
OBJECTIVE: The effects of exogenous melatonin on sleep, daytime sleepiness, fatigue, and alertness were investigated in 22 patients with delayed sleep phase syndrome whose nocturnal sleep was restricted to the interval from 24:00 to 08:00 hours. This study was a randomized, double-blind, placebo-controlled crossover trial. Subjects received either placebo or melatonin (5 mg) daily for 4 weeks, underwent a 1-week washout period, and then were give…
Potential Genetic Overlap Between Insomnia and Sleep Symptoms in Major Depressive Disorder
Background: The prevalence of insomnia and hypersomnia in depressed individuals is substantially higher than that found in the general population. Unfortunately, these concurrent sleep problems can have profound effects on the disease course. Although the full biology of sleep remains to be elucidated, a recent genome-wide association (GWAS) of insomnia, and other sleep traits in over 1 million individuals was recently published and provides many…
Medicine (9 works) · Internal Medicine (7 works) · Internal Medicine (7 works) · Endocrinology (6 works) · Endocrinology (6 works) · Hormone (6 works) · Psychiatry (5 works) · Psychology (5 works) · Stress Responses and Cortisol (4 works) · Adipose Tissue and Metabolism (2 works)