Jean W Maccluer
Biographic Data
| ID | 81595 |
|---|---|
| NAME | Jean W Maccluer |
| GIVEN NAMES | Jean W |
| FAMILY NAME | Maccluer |
| SIGNATURE | MACCLUER J W |
| AFFILIATIONS | Texas Biomedical Research Institute |
| VERIFIED | No |
| TOTAL WORKS | 17 |
| TOTAL CITATIONS | 33 |
| AUTHOR COUNT | 17 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1971 |
| LATEST PUBLICATION YEAR | 2011 |
| H-INDEX | 3 |
Genetic influences on serum bilirubin in American Indians: The strong heart family study
OBJECTIVE: To identify genetic variation influencing serum bilirubin levels in American Indians, we performed genome-wide screening and association analyses in the Strong Heart Family Study. Bilirubin is an endogenous antioxidant that has demonstrated an inverse relationship with cardiovascular disease. Genetic variation within the promoter region of uridine diphosphate glucuronosyltransferase (UGT1A1) on chromosome 2q has been associated with el…
The Genes Influencing Adiponectin Levels Also Influence Risk Factors for Metabolic Syndrome and Type 2 Diabetes
Results from previous studies suggest that adiponectin levels are associated with risk factors for cardiovascular disease and type 2 diabetes mellitus; however, the genetic and/or environmental components of this relationship have not been characterized. The aims of this study were (1) to assess the presence of pleiotropy between adiponectin levels and risk factors for cardiovascular disease and (2) to study the association of circulating levels …
Heritability and Genetic Correlations of Metabolic Disease-Related Phenotypes in Mexico: Preliminary Report from the Gemm Family Study
Cardiovascular disease (CVD) is a major cause of mortality in the Republic of Mexico, and metabolic syndrome, a complex of CVD risk factors, is increasingly prevalent. To date, however, there have been few studies of the genetic epidemiology of metabolic syndrome in Mexico. As a first step in implementing the GEMM Family Study, a large, multicenter collaborative study, we recruited 375 individuals in 21 extended families, without ascertainment on…
Common set of genes regulates low‐density lipoprotein size and obesity‐related factors in Alaskan Eskimos: Results from the Gocadan Study
Increasing incidence of cardiovascular disease in traditionally low‐risk Alaskan Eskimos is a cause for concern. The purpose of this study was to examine the genetic and environmental correlations of low‐density lipoprotein (LDL) subfractions with obesity‐related factors in Alaskan Eskimos, using data from the first 954 participants of the Genetics of Coronary Artery Disease in Alaska Natives Study. Estimates of genetic and environmental influenc…
Multiple QTLs Influence Variation in Paraoxonase 1 Activity in Mexican Americans
Paraoxonase 1 (PON1), a high-density-lipoprotein-associated enzyme known to protect against cellular damage from toxic agents, may also have antioxidant properties. Although the importance of the influence of the PON1 structural locus on chromosome 7q21-22 for variation in the concentration and activity of the enzyme is well-documented, the contribution of other loci is poorly understood. Based on the recent observations of at least one additiona…
Association of Genetic Variation Within UBL5 with Phenotypes of Metabolic Syndrome
The BEACON gene was initially identified using the differential display polymerase chain reaction on hypothalamic mRNA samples collected from lean and obese Psammomys obesus, a polygenic animal model of obesity. Hypothalamic BEACON gene expression was positively correlated with percentage of body fat, and intracerebroventricular infusion of the Beacon protein resulted in a dose-dependent increase in food intake and body weight. The human homolog …
A Locus on Chromosome 13 Influences Levels of Tafi Antigen in Healthy Mexican Americans
When activated, thrombin activatable fibrinolysis inhibitor (TAFI) inhibits fibrinolysis by modifying fibrin, depressing its plasminogen binding potential. Polymorphisms in the TAFI structural gene (CPB2) have been associated with variation in TAFI levels, but the potential occurrence of influential quantitative trait loci (QTLs) located elsewhere in the genome has been explored only in families ascertained in part through probands affected by th…
Heritability of Hemostasis Phenotypes and Their Correlation with Type 2 Diabetes Status in Mexican Americans
Hypercoagulation often occurs in type 2 diabetes, suggesting pleiotropy of the genes that influence disease liability and hemostasis-related phenotypes. To better understand the relationship between hemostasis and diabetes, we first used maximum-likelihood methods to estimate the relative contribution of additive genetic, measured environmental, and shared household effects to the normal variance of 16 hemostasis-related traits in 813 individuals…
Principal Component for Metabolic Syndrome Risk Maps to Chromosome 4p in Mexican Americans: The San Antonio Family Heart Study
Metabolic syndrome refers to the clustering of disease conditions such as insulin resistance, hyperinsulinemia, dyslipidemia, hypertension, and obesity. To explore the genetic predispositions of this complex syndrome, we conducted a principal components analysis using data on 14 phenotypes related to the risk of developing metabolic syndrome. The subjects were 566 nondiabetic Mexican Americans, distributed in 41 extended families from the San Ant…
Gene by Smoking Interaction: Evidence for Effects on Low-Density Lipoprotein Size and Plasma Triglyceride and High-Density Lipoprotein Cholesterol Levels
We seek to determine whether significant gene x smoking interaction effects exist on plasma triglyceride (TG) levels, HDL cholesterol (HDL-C) level, and median LDL particle diameter (LDL-MPD) in Mexican American families enrolled in the San Antonio Family Heart Study. The sample consisted of 1,392 individuals distributed in 42 extended pedigrees, ranging in age from 16 years to 92 years. Separate quantitative genetic analyses were carried out for…
The Genetics of Obesity in Mexican Americans: The Evidence from Genome Scanning Efforts in the San Antonio Family Heart Study
Recent estimates indicate that approximately 18% of the population in the United States can be considered obese (defined as a body mass index [BMI] > or = 30), and this rate is even higher among ethnic populations such as Mexican Americans. This figure becomes very significant given the strong evidence for obesity as a major risk factor for a variety of chronic diseases including type 2 diabetes mellitus and coronary heart disease. The search for…
Quantitative genetics of sexual dimorphism in body fat measurements
A variance decomposition analysis using maximum likelihood methods was employed to examine the genetic architecture of sexual dimorphism in anthropometric traits in a large pedigreed sample of Mexican American individuals from San Antonio, Texas. For this analysis the magnitude of sexual dimorphism was viewed as arising from a special case of genotype by environment interaction (G × E), that of genotype by sex (G × S). Evidence indicates a marked…
Estimating Mortality Level for Small Populations: An Evaluation of a Pair of Two-Census Methods
A pair of two-census methods of estimating mortality levels are tested with simulated census data. The populations considered range in size from 250 to 1500 individuals of each sex; censuses were taken at intervals of five and ten years. In general, the methods are resistant to bias, and yield variances similar in magnitude to those obtained using vital registration data and life table techniques for censored data. The two-census methods represen…
The effects of dominance on mating behavior and paternity in a captive troop of rhesus monkeys ( Macaca mulatta )
The effects of social dominance on male mating behavior and paternity in a troop of rhesus monkeys ( macaca mulatta ) were examined. A wild‐caught troop of monkeys, captured in India in 1972, has been monitored in captivity for eight years. Some animals have been culled from this troop, but no new animals have been added except through births. The social structure of the troop has remained fairly stable over the eight years, although the number o…
Computer Simulation in Human Population Studies
Estimation of vital rates by means of monte carlo simulation
Monte Carlo simulation has been used to estimate age-specific fertility and mortality rates for a small population,the French-derived isolate of Northside on St. Thomas, U. S. Virgin Islands. Estimates were based on data collected in a household census and genealogical survey and on birth, death, and marriage records for the years 1916to 1966. During this 50-year period (in which the population size increased from 202 to 657), the numbers of birt…
Demographic structure of a primitive population: A simulation
A stochastic computer simulation model has been used to study the demography of the Ya̧nomamö Indians of Venezuela and Brazil, whose social organization is typical of many primitive societies. It has been found by simulation that perhaps one third of all Ya̧nomamö marriages involve individuals related as first or second cousins, and that more than 16% of all males must leave their villages to find wives, in spite of a strong preference for villag…
Demographic structure of a primitive population: A simulation
A stochastic computer simulation model has been used to study the demography of the Ya̧nomamö Indians of Venezuela and Brazil, whose social organization is typical of many primitive societies. It has been found by simulation that perhaps one third of all Ya̧nomamö marriages involve individuals related as first or second cousins, and that more than 16% of all males must leave their villages to find wives, in spite of a strong preference for villag…
Heritability and Genetic Correlations of Metabolic Disease-Related Phenotypes in Mexico: Preliminary Report from the Gemm Family Study
Cardiovascular disease (CVD) is a major cause of mortality in the Republic of Mexico, and metabolic syndrome, a complex of CVD risk factors, is increasingly prevalent. To date, however, there have been few studies of the genetic epidemiology of metabolic syndrome in Mexico. As a first step in implementing the GEMM Family Study, a large, multicenter collaborative study, we recruited 375 individuals in 21 extended families, without ascertainment on…
Estimating Mortality Level for Small Populations: An Evaluation of a Pair of Two-Census Methods
A pair of two-census methods of estimating mortality levels are tested with simulated census data. The populations considered range in size from 250 to 1500 individuals of each sex; censuses were taken at intervals of five and ten years. In general, the methods are resistant to bias, and yield variances similar in magnitude to those obtained using vital registration data and life table techniques for censored data. The two-census methods represen…
Gene by Smoking Interaction: Evidence for Effects on Low-Density Lipoprotein Size and Plasma Triglyceride and High-Density Lipoprotein Cholesterol Levels
We seek to determine whether significant gene x smoking interaction effects exist on plasma triglyceride (TG) levels, HDL cholesterol (HDL-C) level, and median LDL particle diameter (LDL-MPD) in Mexican American families enrolled in the San Antonio Family Heart Study. The sample consisted of 1,392 individuals distributed in 42 extended pedigrees, ranging in age from 16 years to 92 years. Separate quantitative genetic analyses were carried out for…
Principal Component for Metabolic Syndrome Risk Maps to Chromosome 4p in Mexican Americans: The San Antonio Family Heart Study
Metabolic syndrome refers to the clustering of disease conditions such as insulin resistance, hyperinsulinemia, dyslipidemia, hypertension, and obesity. To explore the genetic predispositions of this complex syndrome, we conducted a principal components analysis using data on 14 phenotypes related to the risk of developing metabolic syndrome. The subjects were 566 nondiabetic Mexican Americans, distributed in 41 extended families from the San Ant…
The Genetics of Obesity in Mexican Americans: The Evidence from Genome Scanning Efforts in the San Antonio Family Heart Study
Recent estimates indicate that approximately 18% of the population in the United States can be considered obese (defined as a body mass index [BMI] > or = 30), and this rate is even higher among ethnic populations such as Mexican Americans. This figure becomes very significant given the strong evidence for obesity as a major risk factor for a variety of chronic diseases including type 2 diabetes mellitus and coronary heart disease. The search for…
Estimation of vital rates by means of monte carlo simulation
Monte Carlo simulation has been used to estimate age-specific fertility and mortality rates for a small population,the French-derived isolate of Northside on St. Thomas, U. S. Virgin Islands. Estimates were based on data collected in a household census and genealogical survey and on birth, death, and marriage records for the years 1916to 1966. During this 50-year period (in which the population size increased from 202 to 657), the numbers of birt…
Demographic structure of a primitive population: A simulation
A stochastic computer simulation model has been used to study the demography of the Ya̧nomamö Indians of Venezuela and Brazil, whose social organization is typical of many primitive societies. It has been found by simulation that perhaps one third of all Ya̧nomamö marriages involve individuals related as first or second cousins, and that more than 16% of all males must leave their villages to find wives, in spite of a strong preference for villag…
Estimation of vital rates by means of monte carlo simulation
Monte Carlo simulation has been used to estimate age-specific fertility and mortality rates for a small population,the French-derived isolate of Northside on St. Thomas, U. S. Virgin Islands. Estimates were based on data collected in a household census and genealogical survey and on birth, death, and marriage records for the years 1916to 1966. During this 50-year period (in which the population size increased from 202 to 657), the numbers of birt…
Computer Simulation in Human Population Studies
The effects of dominance on mating behavior and paternity in a captive troop of rhesus monkeys ( Macaca mulatta )
The effects of social dominance on male mating behavior and paternity in a troop of rhesus monkeys ( macaca mulatta ) were examined. A wild‐caught troop of monkeys, captured in India in 1972, has been monitored in captivity for eight years. Some animals have been culled from this troop, but no new animals have been added except through births. The social structure of the troop has remained fairly stable over the eight years, although the number o…
Estimating Mortality Level for Small Populations: An Evaluation of a Pair of Two-Census Methods
A pair of two-census methods of estimating mortality levels are tested with simulated census data. The populations considered range in size from 250 to 1500 individuals of each sex; censuses were taken at intervals of five and ten years. In general, the methods are resistant to bias, and yield variances similar in magnitude to those obtained using vital registration data and life table techniques for censored data. The two-census methods represen…
Quantitative genetics of sexual dimorphism in body fat measurements
A variance decomposition analysis using maximum likelihood methods was employed to examine the genetic architecture of sexual dimorphism in anthropometric traits in a large pedigreed sample of Mexican American individuals from San Antonio, Texas. For this analysis the magnitude of sexual dimorphism was viewed as arising from a special case of genotype by environment interaction (G × E), that of genotype by sex (G × S). Evidence indicates a marked…
The Genetics of Obesity in Mexican Americans: The Evidence from Genome Scanning Efforts in the San Antonio Family Heart Study
Recent estimates indicate that approximately 18% of the population in the United States can be considered obese (defined as a body mass index [BMI] > or = 30), and this rate is even higher among ethnic populations such as Mexican Americans. This figure becomes very significant given the strong evidence for obesity as a major risk factor for a variety of chronic diseases including type 2 diabetes mellitus and coronary heart disease. The search for…
Principal Component for Metabolic Syndrome Risk Maps to Chromosome 4p in Mexican Americans: The San Antonio Family Heart Study
Metabolic syndrome refers to the clustering of disease conditions such as insulin resistance, hyperinsulinemia, dyslipidemia, hypertension, and obesity. To explore the genetic predispositions of this complex syndrome, we conducted a principal components analysis using data on 14 phenotypes related to the risk of developing metabolic syndrome. The subjects were 566 nondiabetic Mexican Americans, distributed in 41 extended families from the San Ant…
Gene by Smoking Interaction: Evidence for Effects on Low-Density Lipoprotein Size and Plasma Triglyceride and High-Density Lipoprotein Cholesterol Levels
We seek to determine whether significant gene x smoking interaction effects exist on plasma triglyceride (TG) levels, HDL cholesterol (HDL-C) level, and median LDL particle diameter (LDL-MPD) in Mexican American families enrolled in the San Antonio Family Heart Study. The sample consisted of 1,392 individuals distributed in 42 extended pedigrees, ranging in age from 16 years to 92 years. Separate quantitative genetic analyses were carried out for…
Heritability of Hemostasis Phenotypes and Their Correlation with Type 2 Diabetes Status in Mexican Americans
Hypercoagulation often occurs in type 2 diabetes, suggesting pleiotropy of the genes that influence disease liability and hemostasis-related phenotypes. To better understand the relationship between hemostasis and diabetes, we first used maximum-likelihood methods to estimate the relative contribution of additive genetic, measured environmental, and shared household effects to the normal variance of 16 hemostasis-related traits in 813 individuals…
Common set of genes regulates low‐density lipoprotein size and obesity‐related factors in Alaskan Eskimos: Results from the Gocadan Study
Increasing incidence of cardiovascular disease in traditionally low‐risk Alaskan Eskimos is a cause for concern. The purpose of this study was to examine the genetic and environmental correlations of low‐density lipoprotein (LDL) subfractions with obesity‐related factors in Alaskan Eskimos, using data from the first 954 participants of the Genetics of Coronary Artery Disease in Alaska Natives Study. Estimates of genetic and environmental influenc…
Multiple QTLs Influence Variation in Paraoxonase 1 Activity in Mexican Americans
Paraoxonase 1 (PON1), a high-density-lipoprotein-associated enzyme known to protect against cellular damage from toxic agents, may also have antioxidant properties. Although the importance of the influence of the PON1 structural locus on chromosome 7q21-22 for variation in the concentration and activity of the enzyme is well-documented, the contribution of other loci is poorly understood. Based on the recent observations of at least one additiona…
Association of Genetic Variation Within UBL5 with Phenotypes of Metabolic Syndrome
The BEACON gene was initially identified using the differential display polymerase chain reaction on hypothalamic mRNA samples collected from lean and obese Psammomys obesus, a polygenic animal model of obesity. Hypothalamic BEACON gene expression was positively correlated with percentage of body fat, and intracerebroventricular infusion of the Beacon protein resulted in a dose-dependent increase in food intake and body weight. The human homolog …
A Locus on Chromosome 13 Influences Levels of Tafi Antigen in Healthy Mexican Americans
When activated, thrombin activatable fibrinolysis inhibitor (TAFI) inhibits fibrinolysis by modifying fibrin, depressing its plasminogen binding potential. Polymorphisms in the TAFI structural gene (CPB2) have been associated with variation in TAFI levels, but the potential occurrence of influential quantitative trait loci (QTLs) located elsewhere in the genome has been explored only in families ascertained in part through probands affected by th…
The Genes Influencing Adiponectin Levels Also Influence Risk Factors for Metabolic Syndrome and Type 2 Diabetes
Results from previous studies suggest that adiponectin levels are associated with risk factors for cardiovascular disease and type 2 diabetes mellitus; however, the genetic and/or environmental components of this relationship have not been characterized. The aims of this study were (1) to assess the presence of pleiotropy between adiponectin levels and risk factors for cardiovascular disease and (2) to study the association of circulating levels …
Heritability and Genetic Correlations of Metabolic Disease-Related Phenotypes in Mexico: Preliminary Report from the Gemm Family Study
Cardiovascular disease (CVD) is a major cause of mortality in the Republic of Mexico, and metabolic syndrome, a complex of CVD risk factors, is increasingly prevalent. To date, however, there have been few studies of the genetic epidemiology of metabolic syndrome in Mexico. As a first step in implementing the GEMM Family Study, a large, multicenter collaborative study, we recruited 375 individuals in 21 extended families, without ascertainment on…
Genetic influences on serum bilirubin in American Indians: The strong heart family study
OBJECTIVE: To identify genetic variation influencing serum bilirubin levels in American Indians, we performed genome-wide screening and association analyses in the Strong Heart Family Study. Bilirubin is an endogenous antioxidant that has demonstrated an inverse relationship with cardiovascular disease. Genetic variation within the promoter region of uridine diphosphate glucuronosyltransferase (UGT1A1) on chromosome 2q has been associated with el…
Biology (11 works) · Genetics (11 works) · Gene (9 works) · Demography (8 works) · Endocrinology (8 works) · Medicine (8 works) · Internal Medicine (7 works) · Population (6 works) · Demography (5 works) · Genetic Associations and Epidemiology (5 works)