Gene by Smoking Interaction

Evidence for Effects on Low-Density Lipoprotein Size and Plasma Triglyceride and High-Density Lipoprotein Cholesterol Levels

Bibliographic Data

ID6068053
AuthorsStefan A Czerwinski (Wright State University), Michael C Mahaney (0000-0002-1341-3950), David L Rainwater (0000-0002-3668-4331), John L Vandeberg (0000-0002-7087-979X), Jean W Maccluer, Michael P Stern, John Blangero (0000-0001-6250-5723)
Year2004
Volume76
Issue6
Pages863-876
Publication date2004-01-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueHuman Biology (JOURNAL)
Journal identifiersISSN: 0018-7143 • E-ISSN: 1534-6617
PublisherProject MUSE (PUBLISHER • US)
DOI10.1353/hub.2005.0014
PMID15974298
OpenAlexW2005964783
LanguageEN
Citations received2
References cited5

We seek to determine whether significant gene x smoking interaction effects exist on plasma triglyceride (TG) levels, HDL cholesterol (HDL-C) level, and median LDL particle diameter (LDL-MPD) in Mexican American families enrolled in the San Antonio Family Heart Study. The sample consisted of 1,392 individuals distributed in 42 extended pedigrees, ranging in age from 16 years to 92 years. Separate quantitative genetic analyses were carried out for TG and HDL-C level and LDL-MPD using a maximum-likelihood-based variance decomposition approach while simultaneously adjusting for age and sex. Initial heritability estimates demonstrated significant (p < 0.001) additive genetic contributions to all three traits (h2 range 0.50 - 0.54). To test for a gene x smoking interaction, we included in the model additional smoking-status-specific variance terms and a genetic correlation term between smokers and nonsmokers. Comparisons of nested models revealed significant evidence (p < 0.01) for a gene X smoking interaction effect on TG level and LDL-MPD and possible evidence for an effect on HDL-C level. These results indicate that the gene or suite of genes regulating each of these phenotypes is likely the same in smokers and non-smokers but that smoking may alter the expression of genes, particularly those influencing TG level and LDL-MPD

Additive genetic effects · Biology · Cholesterol · Gene · Gene–environment interaction · Genotype · Heritability · Lipoprotein · Major gene · Pedigree chart · Triglyceride · Endocrinology · Genetic and phenotypic traits in livestock · Genetic Associations and Epidemiology · Genetics · Internal Medicine · Medicine · Obesity, Physical Activity, Diet

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