Stefan A Czerwinski
Biographic Data
| ID | 96070 |
|---|---|
| NAME | Stefan A Czerwinski |
| GIVEN NAMES | Stefan A |
| FAMILY NAME | Czerwinski |
| SIGNATURE | CZERWINSKI S A |
| AFFILIATIONS | Wright State University |
| VERIFIED | No |
| TOTAL WORKS | 21 |
| TOTAL CITATIONS | 38 |
| AUTHOR COUNT | 21 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2002 |
| LATEST PUBLICATION YEAR | 2020 |
| H-INDEX | 3 |
The impact of metabolic syndrome on mental health-related quality of life and depressive symptoms
Inverse associations between cardiometabolic risk factors and 25‐hydroxyvitamin D in obese American children and adolescents
OBJECTIVES: To examine the association between 25-hydroxyvitamin D [25(OH)D] concentrations and cardiometabolic risk factors in obese American children. METHODS: A cross-sectional study was conducted on 209 obese children (55% females, 25.8% black) aged between 6 and 19 years old. Study measurements included plasma 25(OH)D concentrations, blood pressure, lipids and oxidized LDL levels, insulin resistance (IR) indices from glucose, insulin and 5 h…
Wrist breadth and homeostasis model assessment of insulin resistance in youth: The fels longitudinal study
OBJECTIVES: There is biological crosstalk between insulin signaling and bone remodeling pathways, and wrist circumference and bone area were recently found to associate with insulin resistance independent of body mass index (BMI) in overweight/obese children. We aimed to expand on this work by using more specific measures of adiposity for adjustment and examining children with broader range of BMI. METHODS: We used serial data (1,051 total measur…
Characterization of the infant BMI peak: Sex differences, birth year cohort effects, association with concurrent adiposity, and heritability
OBJECTIVES: To characterize an early trait in the BMI-for-age curve, the infant BMI peak. METHODS: BMI-for-age curves were produced for 747 non-Hispanic, white Fels Longitudinal Study participants, from which individual age (AgePeak ) and BMI (BMIPeak ) at maximum infant BMI were estimated. Multivariable general linear regression was used to examine the effects of sex and birth year cohort (1929-1950, 1951-1970, and 1971-2010) on AgePeak and BMIP…
Genetic risk for earlier menarche also influences peripubertal body mass index
It is unclear whether earlier age at menarche is associated with higher body mass index (BMI) because they share a common genetic underpinning. We investigated the impact of single nucleotide polymorphisms (SNPs) influencing menarche timing on peripubertal BMI. For 556 Fels Longitudinal Study children (277 boys/279 girls) born 1928–1992, a genetic risk score (GRS 42 ) was computed as the sum of the number of risk alleles in 42 putative menarche S…
Secular trends in the fat and fat-free components of body mass index in children aged 8–18 years born 1958–1995
Because the long term trend in childhood BMI in boys appears to be driven by an increase in total body adiposity, evidence is provided to support current knowledge on the predicted deleterious long-term consequences of the childhood obesity epidemic in boys. Research is needed to confirm whether recent changes in BMI in girls are due to increases in fat-free mass resulting from changes in behaviour and lifestyle not yet manifest in boys
Bayesian longitudinal plateau model of adult grip strength
OBJECTIVES: This article illustrates the use of applied Bayesian statistical methods in modeling the trajectory of adult grip strength and in evaluating potential risk factors that may influence that trajectory. METHODS: The data consist of from 1 to 11 repeated grip strength measurements from each of 498 men and 533 women age 18-96 years in the Fels Longitudinal Study (Roche AF. 1992. Growth, maturation and body composition: the Fels longitudina…
Significant associations of age, menopausal status and lifestyle factors with visceral adiposity in African-American and European-American women
Greater allocation of abdominal adipose tissue into the visceral compartment occurs in EA than AA women and in older than younger women. Avoidance of cigarette smoking and frequent participation in sports activities may partially counteract this deleterious phenomenon of ageing
Genetic analysis of self-reported physical activity and adiposity: The Southwest Ohio Family Study
Objective Physical inactivity poses a major risk for obesity and chronic disease, and is influenced by both genetic and environmental factors. However, the genetic association between physical activity (PA) level and obesity is not well characterized. Our aims were to: (i) estimate the extent of additive genetic influences on physical activity while adjusting for household effects; and (ii) determine whether physical activity and adiposity measur…
Presentation, Heritability, and Genome-Wide Linkage Analysis the Midchildhood Growth Spurt in Healthy Children from the Fels Longitudinal Study
Growth is a complex process composed of distinct phases over the course of childhood. Although the pubertal growth spurt has received the most attention from auxologists and pediatricians, the midchildhood growth spurt has been less well studied. The midchildhood growth spurt refers to a relatively small increase in growth velocity observed in some, but not necessarily all, children in early to middle childhood. If present, the midchildhood growt…
Presentation, Heritability, and Genome-Wide Linkage Analysis of the Midchildhood Growth Spurt in Healthy Children from the Fels Longitudinal Study
Growth is a complex process composed of distinct phases over the course of childhood. Although the pubertal growth spurt has received the most attention from auxologists and pediatricians, the midchildhood growth spurt has been less well studied. The midchildhood growth spurt refers to a relatively small increase in growth velocity observed in some, but not necessarily all, children in early to middle childhood. If present, the midchildhood growt…
Quantitative genetics of modern human cranial variation
Genetic Architecture of Knee Radiographic Joint Space in Healthy Young Adults
Evidence of a significant genetic component to the age-related degenerative joint disease osteoarthritis has been established, but the nature of genetic influences on normal joint morphology in healthy individuals remains unclear. Following up on our previous findings on the influence of body habitus on phenotypic variation in knee joint space [Duren et al., Human Biology 78:353–364 (2006)], the objective of the current study was to estimate the …
Genetic factors in physical growth and development and their relationship to subsequent health outcomes
Normal physical growth during childhood is influenced by both genetic and environmental factors. However, few studies have examined whether there are shared genetic effects between aspects of child growth and later health outcomes. In this study, we estimate the influence of genetic factors on growth in stature during childhood and determine whether there are pleiotropic effects of genes influencing both childhood growth and later adult health ou…
Genetic and environmental influences on infant weight and weight change: The Fels longitudinal study
Despite significant progress in understanding the mechanisms by which the prenatal/maternal environment can alter development and adult health, genetic influences on normal variation in growth are little understood. This work examines genetic and nongenetic contributions to body weight and weight change during infancy and the relationships between weight change and adult body composition. The dataset included 501 white infants in 164 nuclear and …
Sex differences in young adulthood metabolic syndrome and physical activity: The Fels longitudinal study
Objective. To evaluate the effects of habitual physical activity (PA) on the metabolic syndrome (MS) in young adult men and women. Research methods and procedures. Cross‐sectional PA data were utilized from 249 women and 237 men, aged 18–40 years in the Fels Longitudinal Study. MS components—abdominal circumference (AC), triglycerides (TG), HDL, blood pressure (BP), and fasting glucose (FG)—were dichotomized according to the National Cholesterol …
Heritability of Brachydactyly Type A3 in Children, Adolescents, and Young Adults from an Endogamous Population in Eastern Nepal
Brachymesophalangia-V (BMP-V), a short and broad middle phalanx of the fifth digit, is the most common of all skeletal anomalies of the hand. When this feature appears alone, it is clinically known as brachydactyly type A3 (BDA3). A high prevalence of BDA3 has been observed among the children of the Jirel ethnic group in eastern Nepal. As part of the Jiri Growth Study, a hand-wrist radiograph is taken annually of each child to assess skeletal dev…
Heritability of age at menarche in girls from the Fels Longitudinal Study
Menarche is the hallmark maturational event of female childhood. Many studies indicated a significant genetic contribution to the timing of the onset of menstruation, but most of these studies were limited by the use of retrospective data and by the use of data from only certain types of relatives (i.e., mothers and daughters, sisters, or twin sisters). The primary goal of this study was to use a modern maximum likelihood quantitative genetic met…
Recent decline in age at menarche: The Fels Longitudinal Study
A number of recent reports suggest that the average age at menarche of US girls has declined over the past 20 years. Because the putative declines in the age at menarche are concurrent with increases in childhood body mass index (BMI), it has been suggested that these two trends may be causally linked. We examined differences in mean age of menarche in Fels Longitudinal Study girls who were born in six 10‐year birth cohorts (1930s, 1940s, 1950s, …
Gene by Smoking Interaction: Evidence for Effects on Low-Density Lipoprotein Size and Plasma Triglyceride and High-Density Lipoprotein Cholesterol Levels
We seek to determine whether significant gene x smoking interaction effects exist on plasma triglyceride (TG) levels, HDL cholesterol (HDL-C) level, and median LDL particle diameter (LDL-MPD) in Mexican American families enrolled in the San Antonio Family Heart Study. The sample consisted of 1,392 individuals distributed in 42 extended pedigrees, ranging in age from 16 years to 92 years. Separate quantitative genetic analyses were carried out for…
Crime, Maps and Meaning: Views from a Survey on Safety and CCTV in Germany
In researching CCTV, it must be examined how people assess CCTV measures against the background of their individual knowledge about the technology in question. Research on visual surveillance needs to ask how they sense and perceive cameras. As cameras impact on spatial images and social perceptions, such as security, people's confidence will not be explained solely by showing that cameras do or do not work in reducing crime. For that it is neces…
Heritability of age at menarche in girls from the Fels Longitudinal Study
Menarche is the hallmark maturational event of female childhood. Many studies indicated a significant genetic contribution to the timing of the onset of menstruation, but most of these studies were limited by the use of retrospective data and by the use of data from only certain types of relatives (i.e., mothers and daughters, sisters, or twin sisters). The primary goal of this study was to use a modern maximum likelihood quantitative genetic met…
Quantitative genetics of modern human cranial variation
Heritability of Brachydactyly Type A3 in Children, Adolescents, and Young Adults from an Endogamous Population in Eastern Nepal
Brachymesophalangia-V (BMP-V), a short and broad middle phalanx of the fifth digit, is the most common of all skeletal anomalies of the hand. When this feature appears alone, it is clinically known as brachydactyly type A3 (BDA3). A high prevalence of BDA3 has been observed among the children of the Jirel ethnic group in eastern Nepal. As part of the Jiri Growth Study, a hand-wrist radiograph is taken annually of each child to assess skeletal dev…
Crime, Maps and Meaning: Views from a Survey on Safety and CCTV in Germany
In researching CCTV, it must be examined how people assess CCTV measures against the background of their individual knowledge about the technology in question. Research on visual surveillance needs to ask how they sense and perceive cameras. As cameras impact on spatial images and social perceptions, such as security, people's confidence will not be explained solely by showing that cameras do or do not work in reducing crime. For that it is neces…
Presentation, Heritability, and Genome-Wide Linkage Analysis the Midchildhood Growth Spurt in Healthy Children from the Fels Longitudinal Study
Growth is a complex process composed of distinct phases over the course of childhood. Although the pubertal growth spurt has received the most attention from auxologists and pediatricians, the midchildhood growth spurt has been less well studied. The midchildhood growth spurt refers to a relatively small increase in growth velocity observed in some, but not necessarily all, children in early to middle childhood. If present, the midchildhood growt…
Gene by Smoking Interaction: Evidence for Effects on Low-Density Lipoprotein Size and Plasma Triglyceride and High-Density Lipoprotein Cholesterol Levels
We seek to determine whether significant gene x smoking interaction effects exist on plasma triglyceride (TG) levels, HDL cholesterol (HDL-C) level, and median LDL particle diameter (LDL-MPD) in Mexican American families enrolled in the San Antonio Family Heart Study. The sample consisted of 1,392 individuals distributed in 42 extended pedigrees, ranging in age from 16 years to 92 years. Separate quantitative genetic analyses were carried out for…
Crime, Maps and Meaning: Views from a Survey on Safety and CCTV in Germany
In researching CCTV, it must be examined how people assess CCTV measures against the background of their individual knowledge about the technology in question. Research on visual surveillance needs to ask how they sense and perceive cameras. As cameras impact on spatial images and social perceptions, such as security, people's confidence will not be explained solely by showing that cameras do or do not work in reducing crime. For that it is neces…
Recent decline in age at menarche: The Fels Longitudinal Study
A number of recent reports suggest that the average age at menarche of US girls has declined over the past 20 years. Because the putative declines in the age at menarche are concurrent with increases in childhood body mass index (BMI), it has been suggested that these two trends may be causally linked. We examined differences in mean age of menarche in Fels Longitudinal Study girls who were born in six 10‐year birth cohorts (1930s, 1940s, 1950s, …
Gene by Smoking Interaction: Evidence for Effects on Low-Density Lipoprotein Size and Plasma Triglyceride and High-Density Lipoprotein Cholesterol Levels
We seek to determine whether significant gene x smoking interaction effects exist on plasma triglyceride (TG) levels, HDL cholesterol (HDL-C) level, and median LDL particle diameter (LDL-MPD) in Mexican American families enrolled in the San Antonio Family Heart Study. The sample consisted of 1,392 individuals distributed in 42 extended pedigrees, ranging in age from 16 years to 92 years. Separate quantitative genetic analyses were carried out for…
Heritability of age at menarche in girls from the Fels Longitudinal Study
Menarche is the hallmark maturational event of female childhood. Many studies indicated a significant genetic contribution to the timing of the onset of menstruation, but most of these studies were limited by the use of retrospective data and by the use of data from only certain types of relatives (i.e., mothers and daughters, sisters, or twin sisters). The primary goal of this study was to use a modern maximum likelihood quantitative genetic met…
Genetic factors in physical growth and development and their relationship to subsequent health outcomes
Normal physical growth during childhood is influenced by both genetic and environmental factors. However, few studies have examined whether there are shared genetic effects between aspects of child growth and later health outcomes. In this study, we estimate the influence of genetic factors on growth in stature during childhood and determine whether there are pleiotropic effects of genes influencing both childhood growth and later adult health ou…
Genetic and environmental influences on infant weight and weight change: The Fels longitudinal study
Despite significant progress in understanding the mechanisms by which the prenatal/maternal environment can alter development and adult health, genetic influences on normal variation in growth are little understood. This work examines genetic and nongenetic contributions to body weight and weight change during infancy and the relationships between weight change and adult body composition. The dataset included 501 white infants in 164 nuclear and …
Sex differences in young adulthood metabolic syndrome and physical activity: The Fels longitudinal study
Objective. To evaluate the effects of habitual physical activity (PA) on the metabolic syndrome (MS) in young adult men and women. Research methods and procedures. Cross‐sectional PA data were utilized from 249 women and 237 men, aged 18–40 years in the Fels Longitudinal Study. MS components—abdominal circumference (AC), triglycerides (TG), HDL, blood pressure (BP), and fasting glucose (FG)—were dichotomized according to the National Cholesterol …
Heritability of Brachydactyly Type A3 in Children, Adolescents, and Young Adults from an Endogamous Population in Eastern Nepal
Brachymesophalangia-V (BMP-V), a short and broad middle phalanx of the fifth digit, is the most common of all skeletal anomalies of the hand. When this feature appears alone, it is clinically known as brachydactyly type A3 (BDA3). A high prevalence of BDA3 has been observed among the children of the Jirel ethnic group in eastern Nepal. As part of the Jiri Growth Study, a hand-wrist radiograph is taken annually of each child to assess skeletal dev…
Presentation, Heritability, and Genome-Wide Linkage Analysis the Midchildhood Growth Spurt in Healthy Children from the Fels Longitudinal Study
Growth is a complex process composed of distinct phases over the course of childhood. Although the pubertal growth spurt has received the most attention from auxologists and pediatricians, the midchildhood growth spurt has been less well studied. The midchildhood growth spurt refers to a relatively small increase in growth velocity observed in some, but not necessarily all, children in early to middle childhood. If present, the midchildhood growt…
Presentation, Heritability, and Genome-Wide Linkage Analysis of the Midchildhood Growth Spurt in Healthy Children from the Fels Longitudinal Study
Growth is a complex process composed of distinct phases over the course of childhood. Although the pubertal growth spurt has received the most attention from auxologists and pediatricians, the midchildhood growth spurt has been less well studied. The midchildhood growth spurt refers to a relatively small increase in growth velocity observed in some, but not necessarily all, children in early to middle childhood. If present, the midchildhood growt…
Quantitative genetics of modern human cranial variation
Genetic Architecture of Knee Radiographic Joint Space in Healthy Young Adults
Evidence of a significant genetic component to the age-related degenerative joint disease osteoarthritis has been established, but the nature of genetic influences on normal joint morphology in healthy individuals remains unclear. Following up on our previous findings on the influence of body habitus on phenotypic variation in knee joint space [Duren et al., Human Biology 78:353–364 (2006)], the objective of the current study was to estimate the …
Genetic analysis of self-reported physical activity and adiposity: The Southwest Ohio Family Study
Objective Physical inactivity poses a major risk for obesity and chronic disease, and is influenced by both genetic and environmental factors. However, the genetic association between physical activity (PA) level and obesity is not well characterized. Our aims were to: (i) estimate the extent of additive genetic influences on physical activity while adjusting for household effects; and (ii) determine whether physical activity and adiposity measur…
Bayesian longitudinal plateau model of adult grip strength
OBJECTIVES: This article illustrates the use of applied Bayesian statistical methods in modeling the trajectory of adult grip strength and in evaluating potential risk factors that may influence that trajectory. METHODS: The data consist of from 1 to 11 repeated grip strength measurements from each of 498 men and 533 women age 18-96 years in the Fels Longitudinal Study (Roche AF. 1992. Growth, maturation and body composition: the Fels longitudina…
Significant associations of age, menopausal status and lifestyle factors with visceral adiposity in African-American and European-American women
Greater allocation of abdominal adipose tissue into the visceral compartment occurs in EA than AA women and in older than younger women. Avoidance of cigarette smoking and frequent participation in sports activities may partially counteract this deleterious phenomenon of ageing
Secular trends in the fat and fat-free components of body mass index in children aged 8–18 years born 1958–1995
Because the long term trend in childhood BMI in boys appears to be driven by an increase in total body adiposity, evidence is provided to support current knowledge on the predicted deleterious long-term consequences of the childhood obesity epidemic in boys. Research is needed to confirm whether recent changes in BMI in girls are due to increases in fat-free mass resulting from changes in behaviour and lifestyle not yet manifest in boys
Wrist breadth and homeostasis model assessment of insulin resistance in youth: The fels longitudinal study
OBJECTIVES: There is biological crosstalk between insulin signaling and bone remodeling pathways, and wrist circumference and bone area were recently found to associate with insulin resistance independent of body mass index (BMI) in overweight/obese children. We aimed to expand on this work by using more specific measures of adiposity for adjustment and examining children with broader range of BMI. METHODS: We used serial data (1,051 total measur…
Characterization of the infant BMI peak: Sex differences, birth year cohort effects, association with concurrent adiposity, and heritability
OBJECTIVES: To characterize an early trait in the BMI-for-age curve, the infant BMI peak. METHODS: BMI-for-age curves were produced for 747 non-Hispanic, white Fels Longitudinal Study participants, from which individual age (AgePeak ) and BMI (BMIPeak ) at maximum infant BMI were estimated. Multivariable general linear regression was used to examine the effects of sex and birth year cohort (1929-1950, 1951-1970, and 1971-2010) on AgePeak and BMIP…
Genetic risk for earlier menarche also influences peripubertal body mass index
It is unclear whether earlier age at menarche is associated with higher body mass index (BMI) because they share a common genetic underpinning. We investigated the impact of single nucleotide polymorphisms (SNPs) influencing menarche timing on peripubertal BMI. For 556 Fels Longitudinal Study children (277 boys/279 girls) born 1928–1992, a genetic risk score (GRS 42 ) was computed as the sum of the number of risk alleles in 42 putative menarche S…
Inverse associations between cardiometabolic risk factors and 25‐hydroxyvitamin D in obese American children and adolescents
OBJECTIVES: To examine the association between 25-hydroxyvitamin D [25(OH)D] concentrations and cardiometabolic risk factors in obese American children. METHODS: A cross-sectional study was conducted on 209 obese children (55% females, 25.8% black) aged between 6 and 19 years old. Study measurements included plasma 25(OH)D concentrations, blood pressure, lipids and oxidized LDL levels, insulin resistance (IR) indices from glucose, insulin and 5 h…
The impact of metabolic syndrome on mental health-related quality of life and depressive symptoms
Medicine (19 works) · Demography (16 works) · Internal Medicine (13 works) · Biology (12 works) · Heritability (12 works) · Longitudinal study (11 works) · Body mass index (10 works) · Endocrinology (10 works) · Genetics (10 works) · Obesity (9 works)