Genetic risk for earlier menarche also influences peripubertal body mass index
Bibliographic Data
| ID | 8316518 |
|---|---|
| Authors | William Johnson (0000-0002-0347-4354, University of Minnesota), Audrey C Choh (0000-0001-6365-7411, Wright State University), Joanne E Curran (0000-0002-6898-155X, Texas Biomedical Research Institute), Stefan A Czerwinski (Wright State University), Claire Bellis (0000-0001-5073-9610, Texas Biomedical Research Institute), Thomas D Dyer (0000-0002-5809-1190, Texas Biomedical Research Institute), John Blangero (0000-0001-6250-5723, Texas Biomedical Research Institute), Bradford Towne (Wright State University), Ellen W Demerath (0000-0002-4585-4064, University of Minnesota, corresponding author) |
| Year | 2013 |
| Volume | 150 |
| Issue | 1 |
| Pages | 10-20 |
| Publication date | 2013-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Physical Anthropology (JOURNAL) |
| Journal identifiers | ISSN: 0002-9483 • E-ISSN: 1096-8644 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajpa.22121 |
| PMID | 23283660 |
| PMCID | PMC3539227 |
| OpenAlex | W2003134723 |
| Language | EN |
| Citations received | 1 |
| References cited | 66 |
It is unclear whether earlier age at menarche is associated with higher body mass index (BMI) because they share a common genetic underpinning. We investigated the impact of single nucleotide polymorphisms (SNPs) influencing menarche timing on peripubertal BMI. For 556 Fels Longitudinal Study children (277 boys/279 girls) born 1928–1992, a genetic risk score (GRS 42 ) was computed as the sum of the number of risk alleles in 42 putative menarche SNPs. Serial BMI Z ‐scores within ±6.99 years from each individual's age at peak height velocity (Age@PHV) were grouped into seven time points (−6 years, −4 years, –2 years, Age@PHV, +2 years, +4years, and +6 years). Heritability of BMI ranged from 0.53 to 0.85 across the time points. The effect of GRS 42 on BMI Z ‐scores at each time point was modeled using variance components‐based procedures. GRS 42 had a significant ( P Z ‐scores. A separate score (GRS 29 ) was computed that excluded 13 of the menarche SNPs previously documented to also influence adiposity; significant main effects were observed at Age@PHV+4 and +6 years. This finding supports a causal effect of advanced sexual development on post‐Age@PHV BMI. Significant positive GRS 42 (or GRS 29 )‐by‐birth year interactions indicate that some genetic influences on BMI have amplified over the 20th century. This gene‐by‐environment interaction also suggests that children with a genetic predisposition to earlier sexual development might avoid elevated BMI through alteration of their nutritional environment. Am J Phys Anthropol, 2013. © 2012 Wiley Periodicals, Inc
Biology · Body mass index · Gene · Genotype · Heritability · Longitudinal study · Menarche · Single-nucleotide polymorphism · Demography · Genetics · Growth Hormone and Insulin-like Growth Factors · Hypothalamic control of reproductive hormones · Internal Medicine · Medicine · Reproductive Physiology in Livestock
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| Unique citing works | 1 |
|---|---|
| Citations per year | 0,1 |
| Citation span | 2016 - 2016 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |