Bradford Towne
Biographic Data
| ID | 96069 |
|---|---|
| NAME | Bradford Towne |
| GIVEN NAMES | Bradford |
| FAMILY NAME | Towne |
| SIGNATURE | TOWNE B |
| AFFILIATIONS | Wright State University |
| VERIFIED | No |
| TOTAL WORKS | 23 |
| TOTAL CITATIONS | 35 |
| AUTHOR COUNT | 23 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1987 |
| LATEST PUBLICATION YEAR | 2016 |
| H-INDEX | 3 |
Quantitative physical activity assessment of children and adolescents in a rural population from E astern N epal
OBJECTIVES: We report cross-sectional, objectively measured physical activity data for 399 children and adolescents aged 6 to 18 years. We evaluated physical activity of children and adolescents, considered time spent in each activity intensity category, and explored the impact of growth disruption (stunting and wasting) on physical activity patterns. METHODS: Participants wore an Actical (Mini-Mitter, Bend, OR) omnidirectional accelerometer for …
Nonsyndromic brachydactyly type D and type E mapped to 7p15 in healthy children and adults from the jirel ethnic group in eastern nepal
OBJECTIVES: There is phenotypic overlap between Brachydactyly Type D (BDD) and Brachydactyly Type E (BDE) that suggests a possible common underlying etiology. We seek to understand the genetic underpinnings of, and relationship between, these skeletal anomalies. METHODS: The Jirel ethnic group of eastern Nepal participates in various genetic epidemiologic studies, including those in which hand-wrist radiographs have been taken to examine skeletal…
Characterization of the infant BMI peak: Sex differences, birth year cohort effects, association with concurrent adiposity, and heritability
OBJECTIVES: To characterize an early trait in the BMI-for-age curve, the infant BMI peak. METHODS: BMI-for-age curves were produced for 747 non-Hispanic, white Fels Longitudinal Study participants, from which individual age (AgePeak ) and BMI (BMIPeak ) at maximum infant BMI were estimated. Multivariable general linear regression was used to examine the effects of sex and birth year cohort (1929-1950, 1951-1970, and 1971-2010) on AgePeak and BMIP…
Genetic risk for earlier menarche also influences peripubertal body mass index
It is unclear whether earlier age at menarche is associated with higher body mass index (BMI) because they share a common genetic underpinning. We investigated the impact of single nucleotide polymorphisms (SNPs) influencing menarche timing on peripubertal BMI. For 556 Fels Longitudinal Study children (277 boys/279 girls) born 1928–1992, a genetic risk score (GRS 42 ) was computed as the sum of the number of risk alleles in 42 putative menarche S…
Predicting the timing of maturational spurts in skeletal age
Measures of maturity provide windows into the timing and tempo of childhood growth and maturation. Delayed maturation in a single child, or systemically in a population, can result from either genetic or environmental factors. In terms of the skeleton, delayed maturation may result in short stature or indicate another underlying issue. Thus, prediction of the timing of a maturational spurt is often desirable in order to determine the likelihood t…
Bayesian longitudinal plateau model of adult grip strength
OBJECTIVES: This article illustrates the use of applied Bayesian statistical methods in modeling the trajectory of adult grip strength and in evaluating potential risk factors that may influence that trajectory. METHODS: The data consist of from 1 to 11 repeated grip strength measurements from each of 498 men and 533 women age 18-96 years in the Fels Longitudinal Study (Roche AF. 1992. Growth, maturation and body composition: the Fels longitudina…
Significant associations of age, menopausal status and lifestyle factors with visceral adiposity in African-American and European-American women
Greater allocation of abdominal adipose tissue into the visceral compartment occurs in EA than AA women and in older than younger women. Avoidance of cigarette smoking and frequent participation in sports activities may partially counteract this deleterious phenomenon of ageing
Genetic analysis of self-reported physical activity and adiposity: The Southwest Ohio Family Study
Objective Physical inactivity poses a major risk for obesity and chronic disease, and is influenced by both genetic and environmental factors. However, the genetic association between physical activity (PA) level and obesity is not well characterized. Our aims were to: (i) estimate the extent of additive genetic influences on physical activity while adjusting for household effects; and (ii) determine whether physical activity and adiposity measur…
Presentation, Heritability, and Genome-Wide Linkage Analysis the Midchildhood Growth Spurt in Healthy Children from the Fels Longitudinal Study
Growth is a complex process composed of distinct phases over the course of childhood. Although the pubertal growth spurt has received the most attention from auxologists and pediatricians, the midchildhood growth spurt has been less well studied. The midchildhood growth spurt refers to a relatively small increase in growth velocity observed in some, but not necessarily all, children in early to middle childhood. If present, the midchildhood growt…
Presentation, Heritability, and Genome-Wide Linkage Analysis of the Midchildhood Growth Spurt in Healthy Children from the Fels Longitudinal Study
Growth is a complex process composed of distinct phases over the course of childhood. Although the pubertal growth spurt has received the most attention from auxologists and pediatricians, the midchildhood growth spurt has been less well studied. The midchildhood growth spurt refers to a relatively small increase in growth velocity observed in some, but not necessarily all, children in early to middle childhood. If present, the midchildhood growt…
Quantitative genetics of modern human cranial variation
Genetic Architecture of Knee Radiographic Joint Space in Healthy Young Adults
Evidence of a significant genetic component to the age-related degenerative joint disease osteoarthritis has been established, but the nature of genetic influences on normal joint morphology in healthy individuals remains unclear. Following up on our previous findings on the influence of body habitus on phenotypic variation in knee joint space [Duren et al., Human Biology 78:353–364 (2006)], the objective of the current study was to estimate the …
Genetic factors in physical growth and development and their relationship to subsequent health outcomes
Normal physical growth during childhood is influenced by both genetic and environmental factors. However, few studies have examined whether there are shared genetic effects between aspects of child growth and later health outcomes. In this study, we estimate the influence of genetic factors on growth in stature during childhood and determine whether there are pleiotropic effects of genes influencing both childhood growth and later adult health ou…
Genetic and environmental influences on infant weight and weight change: The Fels longitudinal study
Despite significant progress in understanding the mechanisms by which the prenatal/maternal environment can alter development and adult health, genetic influences on normal variation in growth are little understood. This work examines genetic and nongenetic contributions to body weight and weight change during infancy and the relationships between weight change and adult body composition. The dataset included 501 white infants in 164 nuclear and …
Sex differences in young adulthood metabolic syndrome and physical activity: The Fels longitudinal study
Objective. To evaluate the effects of habitual physical activity (PA) on the metabolic syndrome (MS) in young adult men and women. Research methods and procedures. Cross‐sectional PA data were utilized from 249 women and 237 men, aged 18–40 years in the Fels Longitudinal Study. MS components—abdominal circumference (AC), triglycerides (TG), HDL, blood pressure (BP), and fasting glucose (FG)—were dichotomized according to the National Cholesterol …
Heritability of Brachydactyly Type A3 in Children, Adolescents, and Young Adults from an Endogamous Population in Eastern Nepal
Brachymesophalangia-V (BMP-V), a short and broad middle phalanx of the fifth digit, is the most common of all skeletal anomalies of the hand. When this feature appears alone, it is clinically known as brachydactyly type A3 (BDA3). A high prevalence of BDA3 has been observed among the children of the Jirel ethnic group in eastern Nepal. As part of the Jiri Growth Study, a hand-wrist radiograph is taken annually of each child to assess skeletal dev…
Human Biology Association Abstracts
Heritability of age at menarche in girls from the Fels Longitudinal Study
Menarche is the hallmark maturational event of female childhood. Many studies indicated a significant genetic contribution to the timing of the onset of menstruation, but most of these studies were limited by the use of retrospective data and by the use of data from only certain types of relatives (i.e., mothers and daughters, sisters, or twin sisters). The primary goal of this study was to use a modern maximum likelihood quantitative genetic met…
Recent decline in age at menarche: The Fels Longitudinal Study
A number of recent reports suggest that the average age at menarche of US girls has declined over the past 20 years. Because the putative declines in the age at menarche are concurrent with increases in childhood body mass index (BMI), it has been suggested that these two trends may be causally linked. We examined differences in mean age of menarche in Fels Longitudinal Study girls who were born in six 10‐year birth cohorts (1930s, 1940s, 1950s, …
The relationship of soluble Icam-1, VCAM-1, P-selectin and E-selectin to cardiovascular disease risk factors in healthy men and women
There were no sex differences in the concentrations of sICAM-1, sVCAM-1 and sPSEL, but men had higher sESEL levels than women (p < 0.0001). Male and female smokers had higher sICAM-1 and sESEL levels than non-smokers and soluble cell adhesion molecules (CAMs) were correlated with the pack-years of cigarette smoking (r = 0.3-0.4, p < 0.0001, significant in women only). Significant independent associations were found between soluble CAMs and smokin…
Individual variation in the growth of captive infant gorillas
Serial anthropometric data were obtained during the first year of life of six nursery‐reared infant gorillas in the Columbus (Ohio) Zoo. Two of the infants are likely to be monozygotic twins as determined by DNA analysis. Growth curves were fitted to serial measures of cephalo‐thoracic‐abdominal length, arm length, leg length, head circumference, upper arm circumference, and weight from each gorilla, to describe individual patterns of variation i…
Genetic analysis of sexual dimorphism in serum apo AI and HDL‐C concentrations in baboons
Sexual dimorphism is evident in many quantitative genetic traits, and there has been much speculation on the evolution of primate sexual dimorphism. Morphological characters have been the main focus of attention, while sexual dimorphism in physiological quantitative traits has been neglected. In either case, the genetic basis of primate sexual dimorphism has received little attention. This study characterizes genotype by sex (GxS) interactions in…
Fertility, Sterilization, and Population Growth in Shanti Nagar, India: A Longitudinal Ethnographic Approach . Stanley A. Freed and Ruth S. Freed
Heritability of age at menarche in girls from the Fels Longitudinal Study
Menarche is the hallmark maturational event of female childhood. Many studies indicated a significant genetic contribution to the timing of the onset of menstruation, but most of these studies were limited by the use of retrospective data and by the use of data from only certain types of relatives (i.e., mothers and daughters, sisters, or twin sisters). The primary goal of this study was to use a modern maximum likelihood quantitative genetic met…
Quantitative genetics of modern human cranial variation
Heritability of Brachydactyly Type A3 in Children, Adolescents, and Young Adults from an Endogamous Population in Eastern Nepal
Brachymesophalangia-V (BMP-V), a short and broad middle phalanx of the fifth digit, is the most common of all skeletal anomalies of the hand. When this feature appears alone, it is clinically known as brachydactyly type A3 (BDA3). A high prevalence of BDA3 has been observed among the children of the Jirel ethnic group in eastern Nepal. As part of the Jiri Growth Study, a hand-wrist radiograph is taken annually of each child to assess skeletal dev…
Presentation, Heritability, and Genome-Wide Linkage Analysis the Midchildhood Growth Spurt in Healthy Children from the Fels Longitudinal Study
Growth is a complex process composed of distinct phases over the course of childhood. Although the pubertal growth spurt has received the most attention from auxologists and pediatricians, the midchildhood growth spurt has been less well studied. The midchildhood growth spurt refers to a relatively small increase in growth velocity observed in some, but not necessarily all, children in early to middle childhood. If present, the midchildhood growt…
Individual variation in the growth of captive infant gorillas
Serial anthropometric data were obtained during the first year of life of six nursery‐reared infant gorillas in the Columbus (Ohio) Zoo. Two of the infants are likely to be monozygotic twins as determined by DNA analysis. Growth curves were fitted to serial measures of cephalo‐thoracic‐abdominal length, arm length, leg length, head circumference, upper arm circumference, and weight from each gorilla, to describe individual patterns of variation i…
Fertility, Sterilization, and Population Growth in Shanti Nagar, India: A Longitudinal Ethnographic Approach . Stanley A. Freed and Ruth S. Freed
Genetic analysis of sexual dimorphism in serum apo AI and HDL‐C concentrations in baboons
Sexual dimorphism is evident in many quantitative genetic traits, and there has been much speculation on the evolution of primate sexual dimorphism. Morphological characters have been the main focus of attention, while sexual dimorphism in physiological quantitative traits has been neglected. In either case, the genetic basis of primate sexual dimorphism has received little attention. This study characterizes genotype by sex (GxS) interactions in…
The relationship of soluble Icam-1, VCAM-1, P-selectin and E-selectin to cardiovascular disease risk factors in healthy men and women
There were no sex differences in the concentrations of sICAM-1, sVCAM-1 and sPSEL, but men had higher sESEL levels than women (p < 0.0001). Male and female smokers had higher sICAM-1 and sESEL levels than non-smokers and soluble cell adhesion molecules (CAMs) were correlated with the pack-years of cigarette smoking (r = 0.3-0.4, p < 0.0001, significant in women only). Significant independent associations were found between soluble CAMs and smokin…
Individual variation in the growth of captive infant gorillas
Serial anthropometric data were obtained during the first year of life of six nursery‐reared infant gorillas in the Columbus (Ohio) Zoo. Two of the infants are likely to be monozygotic twins as determined by DNA analysis. Growth curves were fitted to serial measures of cephalo‐thoracic‐abdominal length, arm length, leg length, head circumference, upper arm circumference, and weight from each gorilla, to describe individual patterns of variation i…
Recent decline in age at menarche: The Fels Longitudinal Study
A number of recent reports suggest that the average age at menarche of US girls has declined over the past 20 years. Because the putative declines in the age at menarche are concurrent with increases in childhood body mass index (BMI), it has been suggested that these two trends may be causally linked. We examined differences in mean age of menarche in Fels Longitudinal Study girls who were born in six 10‐year birth cohorts (1930s, 1940s, 1950s, …
Human Biology Association Abstracts
Heritability of age at menarche in girls from the Fels Longitudinal Study
Menarche is the hallmark maturational event of female childhood. Many studies indicated a significant genetic contribution to the timing of the onset of menstruation, but most of these studies were limited by the use of retrospective data and by the use of data from only certain types of relatives (i.e., mothers and daughters, sisters, or twin sisters). The primary goal of this study was to use a modern maximum likelihood quantitative genetic met…
Genetic factors in physical growth and development and their relationship to subsequent health outcomes
Normal physical growth during childhood is influenced by both genetic and environmental factors. However, few studies have examined whether there are shared genetic effects between aspects of child growth and later health outcomes. In this study, we estimate the influence of genetic factors on growth in stature during childhood and determine whether there are pleiotropic effects of genes influencing both childhood growth and later adult health ou…
Genetic and environmental influences on infant weight and weight change: The Fels longitudinal study
Despite significant progress in understanding the mechanisms by which the prenatal/maternal environment can alter development and adult health, genetic influences on normal variation in growth are little understood. This work examines genetic and nongenetic contributions to body weight and weight change during infancy and the relationships between weight change and adult body composition. The dataset included 501 white infants in 164 nuclear and …
Sex differences in young adulthood metabolic syndrome and physical activity: The Fels longitudinal study
Objective. To evaluate the effects of habitual physical activity (PA) on the metabolic syndrome (MS) in young adult men and women. Research methods and procedures. Cross‐sectional PA data were utilized from 249 women and 237 men, aged 18–40 years in the Fels Longitudinal Study. MS components—abdominal circumference (AC), triglycerides (TG), HDL, blood pressure (BP), and fasting glucose (FG)—were dichotomized according to the National Cholesterol …
Heritability of Brachydactyly Type A3 in Children, Adolescents, and Young Adults from an Endogamous Population in Eastern Nepal
Brachymesophalangia-V (BMP-V), a short and broad middle phalanx of the fifth digit, is the most common of all skeletal anomalies of the hand. When this feature appears alone, it is clinically known as brachydactyly type A3 (BDA3). A high prevalence of BDA3 has been observed among the children of the Jirel ethnic group in eastern Nepal. As part of the Jiri Growth Study, a hand-wrist radiograph is taken annually of each child to assess skeletal dev…
Presentation, Heritability, and Genome-Wide Linkage Analysis the Midchildhood Growth Spurt in Healthy Children from the Fels Longitudinal Study
Growth is a complex process composed of distinct phases over the course of childhood. Although the pubertal growth spurt has received the most attention from auxologists and pediatricians, the midchildhood growth spurt has been less well studied. The midchildhood growth spurt refers to a relatively small increase in growth velocity observed in some, but not necessarily all, children in early to middle childhood. If present, the midchildhood growt…
Presentation, Heritability, and Genome-Wide Linkage Analysis of the Midchildhood Growth Spurt in Healthy Children from the Fels Longitudinal Study
Growth is a complex process composed of distinct phases over the course of childhood. Although the pubertal growth spurt has received the most attention from auxologists and pediatricians, the midchildhood growth spurt has been less well studied. The midchildhood growth spurt refers to a relatively small increase in growth velocity observed in some, but not necessarily all, children in early to middle childhood. If present, the midchildhood growt…
Quantitative genetics of modern human cranial variation
Genetic Architecture of Knee Radiographic Joint Space in Healthy Young Adults
Evidence of a significant genetic component to the age-related degenerative joint disease osteoarthritis has been established, but the nature of genetic influences on normal joint morphology in healthy individuals remains unclear. Following up on our previous findings on the influence of body habitus on phenotypic variation in knee joint space [Duren et al., Human Biology 78:353–364 (2006)], the objective of the current study was to estimate the …
Genetic analysis of self-reported physical activity and adiposity: The Southwest Ohio Family Study
Objective Physical inactivity poses a major risk for obesity and chronic disease, and is influenced by both genetic and environmental factors. However, the genetic association between physical activity (PA) level and obesity is not well characterized. Our aims were to: (i) estimate the extent of additive genetic influences on physical activity while adjusting for household effects; and (ii) determine whether physical activity and adiposity measur…
Bayesian longitudinal plateau model of adult grip strength
OBJECTIVES: This article illustrates the use of applied Bayesian statistical methods in modeling the trajectory of adult grip strength and in evaluating potential risk factors that may influence that trajectory. METHODS: The data consist of from 1 to 11 repeated grip strength measurements from each of 498 men and 533 women age 18-96 years in the Fels Longitudinal Study (Roche AF. 1992. Growth, maturation and body composition: the Fels longitudina…
Significant associations of age, menopausal status and lifestyle factors with visceral adiposity in African-American and European-American women
Greater allocation of abdominal adipose tissue into the visceral compartment occurs in EA than AA women and in older than younger women. Avoidance of cigarette smoking and frequent participation in sports activities may partially counteract this deleterious phenomenon of ageing
Nonsyndromic brachydactyly type D and type E mapped to 7p15 in healthy children and adults from the jirel ethnic group in eastern nepal
OBJECTIVES: There is phenotypic overlap between Brachydactyly Type D (BDD) and Brachydactyly Type E (BDE) that suggests a possible common underlying etiology. We seek to understand the genetic underpinnings of, and relationship between, these skeletal anomalies. METHODS: The Jirel ethnic group of eastern Nepal participates in various genetic epidemiologic studies, including those in which hand-wrist radiographs have been taken to examine skeletal…
Characterization of the infant BMI peak: Sex differences, birth year cohort effects, association with concurrent adiposity, and heritability
OBJECTIVES: To characterize an early trait in the BMI-for-age curve, the infant BMI peak. METHODS: BMI-for-age curves were produced for 747 non-Hispanic, white Fels Longitudinal Study participants, from which individual age (AgePeak ) and BMI (BMIPeak ) at maximum infant BMI were estimated. Multivariable general linear regression was used to examine the effects of sex and birth year cohort (1929-1950, 1951-1970, and 1971-2010) on AgePeak and BMIP…
Genetic risk for earlier menarche also influences peripubertal body mass index
It is unclear whether earlier age at menarche is associated with higher body mass index (BMI) because they share a common genetic underpinning. We investigated the impact of single nucleotide polymorphisms (SNPs) influencing menarche timing on peripubertal BMI. For 556 Fels Longitudinal Study children (277 boys/279 girls) born 1928–1992, a genetic risk score (GRS 42 ) was computed as the sum of the number of risk alleles in 42 putative menarche S…
Predicting the timing of maturational spurts in skeletal age
Measures of maturity provide windows into the timing and tempo of childhood growth and maturation. Delayed maturation in a single child, or systemically in a population, can result from either genetic or environmental factors. In terms of the skeleton, delayed maturation may result in short stature or indicate another underlying issue. Thus, prediction of the timing of a maturational spurt is often desirable in order to determine the likelihood t…
Quantitative physical activity assessment of children and adolescents in a rural population from E astern N epal
OBJECTIVES: We report cross-sectional, objectively measured physical activity data for 399 children and adolescents aged 6 to 18 years. We evaluated physical activity of children and adolescents, considered time spent in each activity intensity category, and explored the impact of growth disruption (stunting and wasting) on physical activity patterns. METHODS: Participants wore an Actical (Mini-Mitter, Bend, OR) omnidirectional accelerometer for …
Biology (16 works) · Demography (16 works) · Medicine (16 works) · Genetics (12 works) · Heritability (12 works) · Internal Medicine (10 works) · Endocrinology (9 works) · Longitudinal study (9 works) · Body mass index (8 works) · Population (7 works)