Michael C Mahaney
Biographic Data
| ID | 104475 |
|---|---|
| NAME | Michael C Mahaney |
| GIVEN NAMES | Michael C |
| FAMILY NAME | Mahaney |
| SIGNATURE | MAHANEY M C |
| AFFILIATIONS | Texas Biomedical Research Institute |
| ORCID | 0000-0002-1341-3950 |
| VERIFIED | Yes |
| TOTAL WORKS | 18 |
| TOTAL CITATIONS | 145 |
| AUTHOR COUNT | 18 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1983 |
| LATEST PUBLICATION YEAR | 2025 |
| H-INDEX | 6 |
How local health departments use wastewater surveillance data for public health planning and intervention in New York State
Wastewater surveillance presents a novel data stream for local health departments to understand infectious disease risk in their communities. We conducted a survey of local health departments in New York State regarding their knowledge, attitudes, and practices toward wastewater surveillance of SARS-CoV-2. We further conducted in-depth interviews with a number of local health departments to identify specific use cases of wastewater surveillance d…
Additive genetic variation in the craniofacial skeleton of baboons (genus Papio ) and its relationship to body and cranial size
Objectives Determining the genetic architecture of quantitative traits and genetic correlations among them is important for understanding morphological evolution patterns. We address two questions regarding papionin evolution: (1) what effect do body and cranial size, age, and sex have on phenotypic ( V P ) and additive genetic ( V A ) variation in baboon crania, and (2) how might additive genetic correlations between craniofacial traits and body…
Genetic integration of molar cusp size variation in baboons
Many studies of primate diversity and evolution rely on dental morphology for insight into diet, behavior, and phylogenetic relationships. Consequently, variation in molar cusp size has increasingly become a phenotype of interest. In 2007 we published a quantitative genetic analysis of mandibular molar cusp size variation in baboons. Those results provided more questions than answers, as the pattern of genetic integration did not fit predictions …
Quantitative Trait Locus on Chromosome 12q14.1 Influences Variation in Plasma Plasminogen Levels in the San Antonio Family Heart Study
Plasminogen is a hemostasis-related phenotype and is commonly implicated in thrombotic and bleeding disorders. In the San Antonio Family Heart Study (SAFHS), we performed to our knowledge the first genomewide linkage scan for quantitative trait loci (QTLs) that influence the level of plasminogen. The subset of the SAFHS population used for this study consists of 629 individuals distributed across 26 extended Mexican American families. Pedigree-ba…
Genetic correlations between mandibular molar cusp areas in baboons
Primate evolutionary studies rely significantly on dental variation given the large role that teeth play in how an organism interacts with its environment (animal and plant) and conspecifics. Variation in cusp size has been shown to vary among primate taxa, although most studies to date focused on extant and extinct hominoids. Here we test the assumed hypothesis that a significant proportion of this variation in baboons is due to the additive eff…
Evolution of genetically correlated traits: Tooth size and body size in baboons
Within a population, only phenotypic variation that is influenced by genes will respond to selection. Genes with pleiotropic effects are known to influence numerous traits, complicating our understanding of their evolution through time. Here we use quantitative genetic analyses to identify and estimate the shared genetic effects between molar size and trunk length in a pedigreed, breeding population of baboons housed at the Southwest National Pri…
Multiple QTLs Influence Variation in Paraoxonase 1 Activity in Mexican Americans
Paraoxonase 1 (PON1), a high-density-lipoprotein-associated enzyme known to protect against cellular damage from toxic agents, may also have antioxidant properties. Although the importance of the influence of the PON1 structural locus on chromosome 7q21-22 for variation in the concentration and activity of the enzyme is well-documented, the contribution of other loci is poorly understood. Based on the recent observations of at least one additiona…
Genetics and the evolution of primate enamel thickness: A baboon model
The thickness of mammalian tooth enamel plays a prominent role in paleontology because it correlates with diet, and thicker enamel protects against tooth breakage and wear. Hominid evolutionary studies have stressed the importance of this character for over 30 years, from the identification of “ Ramapithecus ” as an early Miocene hominid, to the recent discovery that the earliest hominids display molar enamel intermediate in thickness between ext…
Gene by Smoking Interaction: Evidence for Effects on Low-Density Lipoprotein Size and Plasma Triglyceride and High-Density Lipoprotein Cholesterol Levels
We seek to determine whether significant gene x smoking interaction effects exist on plasma triglyceride (TG) levels, HDL cholesterol (HDL-C) level, and median LDL particle diameter (LDL-MPD) in Mexican American families enrolled in the San Antonio Family Heart Study. The sample consisted of 1,392 individuals distributed in 42 extended pedigrees, ranging in age from 16 years to 92 years. Separate quantitative genetic analyses were carried out for…
Statistical genetic comparison of two techniques for assessing molar crown size in pedigreed baboons
Dental anthropologists and paleoanthropologists commonly use an estimated molar crown area (mesiodistal length multiplied by buccolingual width) to describe and compare individuals, populations, and species. Advances in digital imaging now allow researchers to measure the actual crown area of a molar in an occlusal two‐dimensional plane. Because error is reduced by this more accurate measurement, actual crown area is thought to be a better repres…
A Quantitative Trait Locus Influencing Activin-to-Estrogen Ratio in Pedigreed Baboons Maps to a Region Homologous to Human Chromosome 19
Activin is a multifunctional hormone playing a major role in the regulation of reproduction and growth and development. We performed a genomewide scan using multipoint linkage analysis implemented in a general pedigree-based variance component approach to identify genes with measurable effects on variation in the activin-to-estrogen ratio in baboons. A microsatellite polymorphism, D19S714, which maps to human chromosome 19p13.2, showed marginal e…
Conservative scoring and exclusion of the phenomenon of interest in linear enamel hypoplasia studies
Conservative criteria are generally employed to select only “sufficiently large” linear enamel defects to be scored as linear enamel hypopasias (LEHs), a practice that excludes enamel defects below arbitrarily selected size thresholds. A question arising is, are such practices likely to exclude small, yet authentic(i.e., physiological stress induced) LEH? The permanent maxillary and mandibular first and second incisors, canines, and first premola…
Quantitative genetics of sexual dimorphism in body fat measurements
A variance decomposition analysis using maximum likelihood methods was employed to examine the genetic architecture of sexual dimorphism in anthropometric traits in a large pedigreed sample of Mexican American individuals from San Antonio, Texas. For this analysis the magnitude of sexual dimorphism was viewed as arising from a special case of genotype by environment interaction (G × E), that of genotype by sex (G × S). Evidence indicates a marked…
Differentially delayed development in the hand–wrist skeletons of children with cystic fibrosis: Round versus tubular bones
From a sample of 50 cystic fibrosis patients in whom a previous study had demosntrated a lack of statistical interdependence between disease severity and significant TW2–20 bone age delays, hand–wrist radiographs for a preadolescent subsample of 30 (14 females and 16 males, 7.4 to 13.0 years of age) are reassessed using the TW2 method to (1) elucidate any significant differences in maturational delays exhibited by the carpals and the tubular bone…
Dental agenesis in the Dariusleut Hutterite brethren: Comparisons to selected caucasoid population surveys
We report the results of a study of the prevalence of nonsyndromic dental agenesis among a sample of 208 individuals (105 females, 103 males) between the ages of 15 and 29 years from a North American religious and genetic isolate, the Dariusleut Hutterites of Western Canada. Direct examination of dental casts, oral examination reports, dental treatment records, and a limited number of dental radiographs reveals congenital absence and/or obvious m…
Stature estimation in prehistoric Native Americans of Ohio
In the present report we investigate stature estimation techniques in a sample of 64 (35 male, 29 female) prehistoric Native Americans from Ohio. Because living stature is unknown for these 64 individuals, we use Fully's (1956) anatomical method to provide the best estimates of living stature. In this method all osseous components of skeletal height are measured and soft tissue correction is added. Comparisons of regression equations commonly use…
On the Classification of Homo
Hominid-Pongid Affinities: A Multivariate Analysis of Hominoid Odontometrics
Genetics and the evolution of primate enamel thickness: A baboon model
The thickness of mammalian tooth enamel plays a prominent role in paleontology because it correlates with diet, and thicker enamel protects against tooth breakage and wear. Hominid evolutionary studies have stressed the importance of this character for over 30 years, from the identification of “ Ramapithecus ” as an early Miocene hominid, to the recent discovery that the earliest hominids display molar enamel intermediate in thickness between ext…
Stature estimation in prehistoric Native Americans of Ohio
In the present report we investigate stature estimation techniques in a sample of 64 (35 male, 29 female) prehistoric Native Americans from Ohio. Because living stature is unknown for these 64 individuals, we use Fully's (1956) anatomical method to provide the best estimates of living stature. In this method all osseous components of skeletal height are measured and soft tissue correction is added. Comparisons of regression equations commonly use…
Statistical genetic comparison of two techniques for assessing molar crown size in pedigreed baboons
Dental anthropologists and paleoanthropologists commonly use an estimated molar crown area (mesiodistal length multiplied by buccolingual width) to describe and compare individuals, populations, and species. Advances in digital imaging now allow researchers to measure the actual crown area of a molar in an occlusal two‐dimensional plane. Because error is reduced by this more accurate measurement, actual crown area is thought to be a better repres…
Genetic integration of molar cusp size variation in baboons
Many studies of primate diversity and evolution rely on dental morphology for insight into diet, behavior, and phylogenetic relationships. Consequently, variation in molar cusp size has increasingly become a phenotype of interest. In 2007 we published a quantitative genetic analysis of mandibular molar cusp size variation in baboons. Those results provided more questions than answers, as the pattern of genetic integration did not fit predictions …
Genetic correlations between mandibular molar cusp areas in baboons
Primate evolutionary studies rely significantly on dental variation given the large role that teeth play in how an organism interacts with its environment (animal and plant) and conspecifics. Variation in cusp size has been shown to vary among primate taxa, although most studies to date focused on extant and extinct hominoids. Here we test the assumed hypothesis that a significant proportion of this variation in baboons is due to the additive eff…
Evolution of genetically correlated traits: Tooth size and body size in baboons
Within a population, only phenotypic variation that is influenced by genes will respond to selection. Genes with pleiotropic effects are known to influence numerous traits, complicating our understanding of their evolution through time. Here we use quantitative genetic analyses to identify and estimate the shared genetic effects between molar size and trunk length in a pedigreed, breeding population of baboons housed at the Southwest National Pri…
Additive genetic variation in the craniofacial skeleton of baboons (genus Papio ) and its relationship to body and cranial size
Objectives Determining the genetic architecture of quantitative traits and genetic correlations among them is important for understanding morphological evolution patterns. We address two questions regarding papionin evolution: (1) what effect do body and cranial size, age, and sex have on phenotypic ( V P ) and additive genetic ( V A ) variation in baboon crania, and (2) how might additive genetic correlations between craniofacial traits and body…
Gene by Smoking Interaction: Evidence for Effects on Low-Density Lipoprotein Size and Plasma Triglyceride and High-Density Lipoprotein Cholesterol Levels
We seek to determine whether significant gene x smoking interaction effects exist on plasma triglyceride (TG) levels, HDL cholesterol (HDL-C) level, and median LDL particle diameter (LDL-MPD) in Mexican American families enrolled in the San Antonio Family Heart Study. The sample consisted of 1,392 individuals distributed in 42 extended pedigrees, ranging in age from 16 years to 92 years. Separate quantitative genetic analyses were carried out for…
Dental agenesis in the Dariusleut Hutterite brethren: Comparisons to selected caucasoid population surveys
We report the results of a study of the prevalence of nonsyndromic dental agenesis among a sample of 208 individuals (105 females, 103 males) between the ages of 15 and 29 years from a North American religious and genetic isolate, the Dariusleut Hutterites of Western Canada. Direct examination of dental casts, oral examination reports, dental treatment records, and a limited number of dental radiographs reveals congenital absence and/or obvious m…
Hominid-Pongid Affinities: A Multivariate Analysis of Hominoid Odontometrics
On the Classification of Homo
Dental agenesis in the Dariusleut Hutterite brethren: Comparisons to selected caucasoid population surveys
We report the results of a study of the prevalence of nonsyndromic dental agenesis among a sample of 208 individuals (105 females, 103 males) between the ages of 15 and 29 years from a North American religious and genetic isolate, the Dariusleut Hutterites of Western Canada. Direct examination of dental casts, oral examination reports, dental treatment records, and a limited number of dental radiographs reveals congenital absence and/or obvious m…
Stature estimation in prehistoric Native Americans of Ohio
In the present report we investigate stature estimation techniques in a sample of 64 (35 male, 29 female) prehistoric Native Americans from Ohio. Because living stature is unknown for these 64 individuals, we use Fully's (1956) anatomical method to provide the best estimates of living stature. In this method all osseous components of skeletal height are measured and soft tissue correction is added. Comparisons of regression equations commonly use…
Differentially delayed development in the hand–wrist skeletons of children with cystic fibrosis: Round versus tubular bones
From a sample of 50 cystic fibrosis patients in whom a previous study had demosntrated a lack of statistical interdependence between disease severity and significant TW2–20 bone age delays, hand–wrist radiographs for a preadolescent subsample of 30 (14 females and 16 males, 7.4 to 13.0 years of age) are reassessed using the TW2 method to (1) elucidate any significant differences in maturational delays exhibited by the carpals and the tubular bone…
Quantitative genetics of sexual dimorphism in body fat measurements
A variance decomposition analysis using maximum likelihood methods was employed to examine the genetic architecture of sexual dimorphism in anthropometric traits in a large pedigreed sample of Mexican American individuals from San Antonio, Texas. For this analysis the magnitude of sexual dimorphism was viewed as arising from a special case of genotype by environment interaction (G × E), that of genotype by sex (G × S). Evidence indicates a marked…
Conservative scoring and exclusion of the phenomenon of interest in linear enamel hypoplasia studies
Conservative criteria are generally employed to select only “sufficiently large” linear enamel defects to be scored as linear enamel hypopasias (LEHs), a practice that excludes enamel defects below arbitrarily selected size thresholds. A question arising is, are such practices likely to exclude small, yet authentic(i.e., physiological stress induced) LEH? The permanent maxillary and mandibular first and second incisors, canines, and first premola…
A Quantitative Trait Locus Influencing Activin-to-Estrogen Ratio in Pedigreed Baboons Maps to a Region Homologous to Human Chromosome 19
Activin is a multifunctional hormone playing a major role in the regulation of reproduction and growth and development. We performed a genomewide scan using multipoint linkage analysis implemented in a general pedigree-based variance component approach to identify genes with measurable effects on variation in the activin-to-estrogen ratio in baboons. A microsatellite polymorphism, D19S714, which maps to human chromosome 19p13.2, showed marginal e…
Statistical genetic comparison of two techniques for assessing molar crown size in pedigreed baboons
Dental anthropologists and paleoanthropologists commonly use an estimated molar crown area (mesiodistal length multiplied by buccolingual width) to describe and compare individuals, populations, and species. Advances in digital imaging now allow researchers to measure the actual crown area of a molar in an occlusal two‐dimensional plane. Because error is reduced by this more accurate measurement, actual crown area is thought to be a better repres…
Genetics and the evolution of primate enamel thickness: A baboon model
The thickness of mammalian tooth enamel plays a prominent role in paleontology because it correlates with diet, and thicker enamel protects against tooth breakage and wear. Hominid evolutionary studies have stressed the importance of this character for over 30 years, from the identification of “ Ramapithecus ” as an early Miocene hominid, to the recent discovery that the earliest hominids display molar enamel intermediate in thickness between ext…
Gene by Smoking Interaction: Evidence for Effects on Low-Density Lipoprotein Size and Plasma Triglyceride and High-Density Lipoprotein Cholesterol Levels
We seek to determine whether significant gene x smoking interaction effects exist on plasma triglyceride (TG) levels, HDL cholesterol (HDL-C) level, and median LDL particle diameter (LDL-MPD) in Mexican American families enrolled in the San Antonio Family Heart Study. The sample consisted of 1,392 individuals distributed in 42 extended pedigrees, ranging in age from 16 years to 92 years. Separate quantitative genetic analyses were carried out for…
Evolution of genetically correlated traits: Tooth size and body size in baboons
Within a population, only phenotypic variation that is influenced by genes will respond to selection. Genes with pleiotropic effects are known to influence numerous traits, complicating our understanding of their evolution through time. Here we use quantitative genetic analyses to identify and estimate the shared genetic effects between molar size and trunk length in a pedigreed, breeding population of baboons housed at the Southwest National Pri…
Multiple QTLs Influence Variation in Paraoxonase 1 Activity in Mexican Americans
Paraoxonase 1 (PON1), a high-density-lipoprotein-associated enzyme known to protect against cellular damage from toxic agents, may also have antioxidant properties. Although the importance of the influence of the PON1 structural locus on chromosome 7q21-22 for variation in the concentration and activity of the enzyme is well-documented, the contribution of other loci is poorly understood. Based on the recent observations of at least one additiona…
Quantitative Trait Locus on Chromosome 12q14.1 Influences Variation in Plasma Plasminogen Levels in the San Antonio Family Heart Study
Plasminogen is a hemostasis-related phenotype and is commonly implicated in thrombotic and bleeding disorders. In the San Antonio Family Heart Study (SAFHS), we performed to our knowledge the first genomewide linkage scan for quantitative trait loci (QTLs) that influence the level of plasminogen. The subset of the SAFHS population used for this study consists of 629 individuals distributed across 26 extended Mexican American families. Pedigree-ba…
Genetic correlations between mandibular molar cusp areas in baboons
Primate evolutionary studies rely significantly on dental variation given the large role that teeth play in how an organism interacts with its environment (animal and plant) and conspecifics. Variation in cusp size has been shown to vary among primate taxa, although most studies to date focused on extant and extinct hominoids. Here we test the assumed hypothesis that a significant proportion of this variation in baboons is due to the additive eff…
Genetic integration of molar cusp size variation in baboons
Many studies of primate diversity and evolution rely on dental morphology for insight into diet, behavior, and phylogenetic relationships. Consequently, variation in molar cusp size has increasingly become a phenotype of interest. In 2007 we published a quantitative genetic analysis of mandibular molar cusp size variation in baboons. Those results provided more questions than answers, as the pattern of genetic integration did not fit predictions …
Additive genetic variation in the craniofacial skeleton of baboons (genus Papio ) and its relationship to body and cranial size
Objectives Determining the genetic architecture of quantitative traits and genetic correlations among them is important for understanding morphological evolution patterns. We address two questions regarding papionin evolution: (1) what effect do body and cranial size, age, and sex have on phenotypic ( V P ) and additive genetic ( V A ) variation in baboon crania, and (2) how might additive genetic correlations between craniofacial traits and body…
How local health departments use wastewater surveillance data for public health planning and intervention in New York State
Wastewater surveillance presents a novel data stream for local health departments to understand infectious disease risk in their communities. We conducted a survey of local health departments in New York State regarding their knowledge, attitudes, and practices toward wastewater surveillance of SARS-CoV-2. We further conducted in-depth interviews with a number of local health departments to identify specific use cases of wastewater surveillance d…
Biology (13 works) · Genetics (11 works) · Genetics (8 works) · Evolutionary biology (7 works) · Gene (7 works) · Medicine (7 works) · Demography (6 works) · Mathematics (6 works) · Molar (6 works) · Wildlife Ecology and Conservation (6 works)