A Quantitative Trait Locus Influencing Activin-to-Estrogen Ratio in Pedigreed Baboons Maps to a Region Homologous to Human Chromosome 19
Bibliographic Data
| ID | 6067355 |
|---|---|
| Authors | Lisa J Martins (0000-0001-8702-9946), John Blangero (0000-0001-6250-5723), Jeffrey Rogers (0000-0002-7374-6490), Michael C Mahaney (0000-0002-1341-3950), James E Hixson (0000-0002-0849-9315), K Dee Carey, Anthony G Comuzzie (0000-0001-9345-157X) |
| Year | 2001 |
| Volume | 73 |
| Issue | 6 |
| Pages | 787-800 |
| Publication date | 2001-01-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Human Biology (JOURNAL) |
| Journal identifiers | ISSN: 0018-7143 • E-ISSN: 1534-6617 |
| Publisher | Project MUSE (PUBLISHER • US) |
| DOI | 10.1353/hub.2001.0086 |
| PMID | 11804195 |
| OpenAlex | W1968753485 |
| Language | EN |
Activin is a multifunctional hormone playing a major role in the regulation of reproduction and growth and development. We performed a genomewide scan using multipoint linkage analysis implemented in a general pedigree-based variance component approach to identify genes with measurable effects on variation in the activin-to-estrogen ratio in baboons. A microsatellite polymorphism, D19S714, which maps to human chromosome 19p13.2, showed marginal evidence of linkage with a lod (log10 of the odds in favor of genetic linkage) score of 1.95 (0.014). This region contains several potential candidate genes including PKA (protein kinase, cAMP-dependent, catalytic alpha) and the gene pair JUN-B and JUN-D. This is the first evidence of a quantitative trait locus with a significant effect on the activin-to-estrogen ratio
Allele · Biology · Candidate gene · Estrogen · Gene · Genetic linkage · Locus (genetics · Microsatellite · Quantitative trait locus · Genetic Syndromes and Imprinting · Growth Hormone and Insulin-like Growth Factors · TGF-β signaling in diseases · Genetics
| Citation velocity | historical |
|---|---|
| Highly cited | No |